IL113599A - 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them - Google Patents
5-aryl pyrimidines, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL113599A IL113599A IL113599A IL11359995A IL113599A IL 113599 A IL113599 A IL 113599A IL 113599 A IL113599 A IL 113599A IL 11359995 A IL11359995 A IL 11359995A IL 113599 A IL113599 A IL 113599A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- halo
- alkyl
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Paper (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909012316A GB9012316D0 (en) | 1990-06-01 | 1990-06-01 | Pharmacologically active cns compounds |
IL9833091A IL98330A (en) | 1990-06-01 | 1991-05-31 | 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations |
Publications (2)
Publication Number | Publication Date |
---|---|
IL113599A0 IL113599A0 (en) | 1995-08-31 |
IL113599A true IL113599A (en) | 1997-09-30 |
Family
ID=10676964
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9833091A IL98330A (en) | 1990-06-01 | 1991-05-31 | 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations |
IL113599A IL113599A (en) | 1990-06-01 | 1991-05-31 | 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9833091A IL98330A (en) | 1990-06-01 | 1991-05-31 | 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations |
Country Status (25)
Country | Link |
---|---|
EP (2) | EP0459819B1 (de) |
JP (1) | JPH06340634A (de) |
KR (1) | KR920000733A (de) |
AT (1) | ATE141263T1 (de) |
AU (2) | AU652753B2 (de) |
CA (1) | CA2043640A1 (de) |
CZ (1) | CZ281070B6 (de) |
DE (1) | DE69121317T2 (de) |
DK (1) | DK0459819T3 (de) |
ES (1) | ES2093078T3 (de) |
FI (1) | FI912623A (de) |
GB (1) | GB9012316D0 (de) |
GR (1) | GR3021237T3 (de) |
HU (2) | HUT58707A (de) |
IE (1) | IE911861A1 (de) |
IL (2) | IL98330A (de) |
MY (2) | MY136248A (de) |
NO (1) | NO180375C (de) |
NZ (3) | NZ248501A (de) |
PL (2) | PL170373B1 (de) |
PT (1) | PT97827B (de) |
RU (1) | RU2091374C1 (de) |
SK (1) | SK278444B6 (de) |
TW (1) | TW224460B (de) |
ZA (1) | ZA914165B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
MY110880A (en) * | 1991-01-30 | 1999-06-30 | The Wellcome Foundation Ltd | Water-dispersible tablets |
US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
GB9226377D0 (en) * | 1992-12-18 | 1993-02-10 | Babbedge Rachel C | Pharmaceutical compositions |
EP0674627A1 (de) * | 1992-12-18 | 1995-10-04 | The Wellcome Foundation Limited | Pyrimidin-, pyridin-, pteridinon- und indazolderivate als enzyminhibitoren |
US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
GB9319341D0 (en) * | 1993-09-17 | 1993-11-03 | Wellcome Found | Novel process |
FR2741879A1 (fr) * | 1995-12-05 | 1997-06-06 | Esteve Labor Dr | Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
EP1219609B1 (de) | 1999-09-16 | 2007-04-04 | Tanabe Seiyaku Co., Ltd. | Aromatische stickstoffhältige sechs-ring-verbindungen |
CN1440393A (zh) | 2000-04-28 | 2003-09-03 | 田边制药株式会社 | 环状化合物 |
US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
CA2416442C (en) * | 2000-07-24 | 2010-06-08 | Krenitsky Pharmaceuticals, Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
KR100540623B1 (ko) | 2001-02-26 | 2006-01-11 | 다나베 세이야꾸 가부시키가이샤 | 피리도피리미딘 또는 나프틸리딘 유도체 |
MXPA04007612A (es) * | 2002-02-05 | 2004-11-10 | Novo Nordisk As | Aril- y heteroarilpiperazinas novedosas. |
TW200637556A (en) * | 2005-01-31 | 2006-11-01 | Basf Ag | Substituted 5-phenyl pyrimidines I in therapy |
US8501739B2 (en) | 2005-07-04 | 2013-08-06 | High Point Pharmaceuticals, Llc | Medicaments |
JP2009537596A (ja) | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 6−(4−シクロプロピルピペリジン−1−イル)−2’−メチル−[3,4’]−ビピリジン及びその医薬としての使用 |
KR20090040259A (ko) | 2006-05-29 | 2009-04-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 h3 수용체 안타고니스트로서의 용도 |
EP2014656A3 (de) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Neue heterocyclische H3-Antagonisten |
SG194219A1 (en) * | 2011-06-10 | 2013-11-29 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
US10093646B2 (en) | 2014-01-17 | 2018-10-09 | Novartis Ag | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 |
JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
WO2017216706A1 (en) | 2016-06-14 | 2017-12-21 | Novartis Ag | Compounds and compositions for inhibiting the activity of shp2 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE518622A (de) * | ||||
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
US5136080A (en) * | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
-
1990
- 1990-06-01 GB GB909012316A patent/GB9012316D0/en active Pending
-
1991
- 1991-05-30 ZA ZA914165A patent/ZA914165B/xx unknown
- 1991-05-31 IL IL9833091A patent/IL98330A/en active IP Right Grant
- 1991-05-31 CZ CS911643A patent/CZ281070B6/cs unknown
- 1991-05-31 IE IE186191A patent/IE911861A1/en unknown
- 1991-05-31 PL PL91305331A patent/PL170373B1/pl unknown
- 1991-05-31 NZ NZ248501A patent/NZ248501A/en unknown
- 1991-05-31 CA CA002043640A patent/CA2043640A1/en not_active Abandoned
- 1991-05-31 DE DE69121317T patent/DE69121317T2/de not_active Expired - Fee Related
- 1991-05-31 FI FI912623A patent/FI912623A/fi not_active Application Discontinuation
- 1991-05-31 SK SK1643-91A patent/SK278444B6/sk unknown
- 1991-05-31 RU SU914895583A patent/RU2091374C1/ru active
- 1991-05-31 PT PT97827A patent/PT97827B/pt not_active IP Right Cessation
- 1991-05-31 AU AU78097/91A patent/AU652753B2/en not_active Ceased
- 1991-05-31 MY MYPI95001459A patent/MY136248A/en unknown
- 1991-05-31 TW TW080104285A patent/TW224460B/zh active
- 1991-05-31 PL PL91290496A patent/PL166656B1/pl unknown
- 1991-05-31 EP EP91304935A patent/EP0459819B1/de not_active Expired - Lifetime
- 1991-05-31 NZ NZ272001A patent/NZ272001A/en unknown
- 1991-05-31 KR KR1019910009010A patent/KR920000733A/ko not_active Application Discontinuation
- 1991-05-31 MY MYPI91000962A patent/MY109958A/en unknown
- 1991-05-31 HU HU911826A patent/HUT58707A/hu unknown
- 1991-05-31 AT AT91304935T patent/ATE141263T1/de not_active IP Right Cessation
- 1991-05-31 NZ NZ238360A patent/NZ238360A/en unknown
- 1991-05-31 JP JP3235334A patent/JPH06340634A/ja active Pending
- 1991-05-31 NO NO912100A patent/NO180375C/no unknown
- 1991-05-31 DK DK91304935.9T patent/DK0459819T3/da active
- 1991-05-31 ES ES91304935T patent/ES2093078T3/es not_active Expired - Lifetime
- 1991-05-31 EP EP95111314A patent/EP0679645A1/de not_active Withdrawn
- 1991-05-31 IL IL113599A patent/IL113599A/xx not_active IP Right Cessation
-
1994
- 1994-07-13 AU AU67455/94A patent/AU680252B2/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00669P patent/HU211649A9/hu unknown
-
1996
- 1996-10-03 GR GR960402585T patent/GR3021237T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
EXP | Patent expired | ||
RH | Patent void |