FI912623A - Farmakologiskt aktiva foereningar med verkan pao det centrala nervsystemet. - Google Patents

Farmakologiskt aktiva foereningar med verkan pao det centrala nervsystemet. Download PDF

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Publication number
FI912623A
FI912623A FI912623A FI912623A FI912623A FI 912623 A FI912623 A FI 912623A FI 912623 A FI912623 A FI 912623A FI 912623 A FI912623 A FI 912623A FI 912623 A FI912623 A FI 912623A
Authority
FI
Finland
Prior art keywords
hydrogen
halo
alkyl
central network
nitro
Prior art date
Application number
FI912623A
Other languages
English (en)
Finnish (fi)
Other versions
FI912623A0 (fi
Inventor
Michael John Leach
Malcolm Stuart Nobbs
Ramachandran Iyer
Clive Leonard Yeates
Philip Alan Skone
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI912623A0 publication Critical patent/FI912623A0/fi
Publication of FI912623A publication Critical patent/FI912623A/fi
Priority to FI961410A priority Critical patent/FI961410A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
  • Medicinal Preparation (AREA)
FI912623A 1990-06-01 1991-05-31 Farmakologiskt aktiva foereningar med verkan pao det centrala nervsystemet. FI912623A (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI961410A FI961410A0 (fi) 1990-06-01 1996-03-28 Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (2)

Publication Number Publication Date
FI912623A0 FI912623A0 (fi) 1991-05-31
FI912623A true FI912623A (fi) 1991-12-02

Family

ID=10676964

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912623A FI912623A (fi) 1990-06-01 1991-05-31 Farmakologiskt aktiva foereningar med verkan pao det centrala nervsystemet.

Country Status (25)

Country Link
EP (2) EP0459819B1 (de)
JP (1) JPH06340634A (de)
KR (1) KR920000733A (de)
AT (1) ATE141263T1 (de)
AU (2) AU652753B2 (de)
CA (1) CA2043640A1 (de)
CZ (1) CZ281070B6 (de)
DE (1) DE69121317T2 (de)
DK (1) DK0459819T3 (de)
ES (1) ES2093078T3 (de)
FI (1) FI912623A (de)
GB (1) GB9012316D0 (de)
GR (1) GR3021237T3 (de)
HU (2) HUT58707A (de)
IE (1) IE911861A1 (de)
IL (2) IL98330A (de)
MY (2) MY136248A (de)
NO (1) NO180375C (de)
NZ (3) NZ272001A (de)
PL (2) PL170373B1 (de)
PT (1) PT97827B (de)
RU (1) RU2091374C1 (de)
SK (1) SK278444B6 (de)
TW (1) TW224460B (de)
ZA (1) ZA914165B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
FR2671970B1 (fr) * 1991-01-30 1995-06-23 Wellcome Found Comprimes dispersables dans l'eau.
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
WO1994014780A1 (en) * 1992-12-18 1994-07-07 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
IL148291A0 (en) 1999-09-16 2002-09-12 Tanabe Seiyaku Co Aromatic nitrogen-containing 6-membered cyclic compounds
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
CN1657523A (zh) 2000-04-28 2005-08-24 田边制药株式会社 环状化合物
CA2416442C (en) * 2000-07-24 2010-06-08 Krenitsky Pharmaceuticals, Inc. Substituted 5-alkynyl pyrimidines having neurotrophic activity
MXPA03007623A (es) 2001-02-26 2003-12-04 Tanabe Seiyaku Co Derivado de piridopirimidina o naftiridina.
CA2474214A1 (en) * 2002-02-05 2003-08-14 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
WO2007003604A2 (en) 2005-07-04 2007-01-11 Novo Nordisk A/S Hists1mine h3 receptor antagonists
EP2038256A1 (de) 2006-05-23 2009-03-25 TransTech Pharma, Inc 6-(4-cyclopropylpiperazin-1-yl)-2'-methyl-[3,4']-bipyridin und seine verwendung als arzneimittel
US8378097B2 (en) 2006-05-29 2013-02-19 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
EP2014656A3 (de) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Neue heterocyclische H3-Antagonisten
SG10201801668WA (en) 2011-06-10 2018-03-28 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity
ES2699351T3 (es) 2014-01-17 2019-02-08 Novartis Ag Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
PL3468972T3 (pl) 2016-06-14 2020-11-16 Novartis Ag Związki i kompozycje do hamowania aktywności shp2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (de) *
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
AU652753B2 (en) 1994-09-08
DK0459819T3 (da) 1996-09-02
EP0679645A1 (de) 1995-11-02
DE69121317D1 (de) 1996-09-19
TW224460B (de) 1994-06-01
GR3021237T3 (en) 1997-01-31
PL166656B1 (pl) 1995-06-30
ATE141263T1 (de) 1996-08-15
NO180375B (no) 1996-12-30
ZA914165B (en) 1993-03-01
EP0459819A3 (en) 1992-03-11
KR920000733A (ko) 1992-01-29
CA2043640A1 (en) 1991-12-02
JPH06340634A (ja) 1994-12-13
SK278444B6 (en) 1997-05-07
PT97827A (pt) 1992-03-31
FI912623A0 (fi) 1991-05-31
GB9012316D0 (en) 1990-07-18
HU911826D0 (en) 1991-12-30
CZ281070B6 (cs) 1996-06-12
ES2093078T3 (es) 1996-12-16
PT97827B (pt) 1998-10-30
IL113599A0 (en) 1995-08-31
MY109958A (en) 1997-10-31
IL98330A0 (en) 1992-06-21
IL113599A (en) 1997-09-30
NO912100L (no) 1991-12-02
AU7809791A (en) 1991-12-05
AU680252B2 (en) 1997-07-24
EP0459819A2 (de) 1991-12-04
NZ238360A (en) 1997-03-24
RU2091374C1 (ru) 1997-09-27
NZ248501A (en) 1997-03-24
HU211649A9 (en) 1995-12-28
HUT58707A (en) 1992-03-30
IL98330A (en) 1996-10-31
EP0459819B1 (de) 1996-08-14
CS164391A3 (en) 1992-02-19
NO912100D0 (no) 1991-05-31
NO180375C (no) 1997-04-09
MY136248A (en) 2008-08-29
DE69121317T2 (de) 1997-01-02
NZ272001A (en) 1997-03-24
AU6745594A (en) 1994-09-15
PL170373B1 (pl) 1996-12-31
IE911861A1 (en) 1991-12-04

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