IL112759A0 - Novel cysteine protease inhibitors - Google Patents

Novel cysteine protease inhibitors

Info

Publication number
IL112759A0
IL112759A0 IL11275995A IL11275995A IL112759A0 IL 112759 A0 IL112759 A0 IL 112759A0 IL 11275995 A IL11275995 A IL 11275995A IL 11275995 A IL11275995 A IL 11275995A IL 112759 A0 IL112759 A0 IL 112759A0
Authority
IL
Israel
Prior art keywords
protease inhibitors
cysteine protease
novel cysteine
novel
inhibitors
Prior art date
Application number
IL11275995A
Other languages
English (en)
Original Assignee
Khepri Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Khepri Pharmaceuticals Inc filed Critical Khepri Pharmaceuticals Inc
Publication of IL112759A0 publication Critical patent/IL112759A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
IL11275995A 1994-02-25 1995-02-23 Novel cysteine protease inhibitors IL112759A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20205194A 1994-02-25 1994-02-25

Publications (1)

Publication Number Publication Date
IL112759A0 true IL112759A0 (en) 1995-05-26

Family

ID=22748336

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11275995A IL112759A0 (en) 1994-02-25 1995-02-23 Novel cysteine protease inhibitors

Country Status (8)

Country Link
US (2) US5976858A (fr)
EP (1) EP0756625A4 (fr)
AU (1) AU708414B2 (fr)
CA (1) CA2184098A1 (fr)
IL (1) IL112759A0 (fr)
NZ (1) NZ282946A (fr)
WO (1) WO1995023222A1 (fr)
ZA (1) ZA951573B (fr)

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CA2215211A1 (fr) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Inhibiteur de la protease de cysteine
EP1400530A1 (fr) * 1996-04-22 2004-03-24 Massachusetts Institute Of Technology Suppression d'un réponse immunitaire par inhibition de cathepsin S
CA2251714A1 (fr) 1996-04-22 1997-10-30 Massachusetts Institute Of Technology Suppression de reponse immunitaire par inhibition de cathepsine s
US6214799B1 (en) 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US5856530A (en) * 1996-05-14 1999-01-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
JPH1067680A (ja) * 1996-08-27 1998-03-10 Kaki Kenkyusho 魚介類の幼生用細菌感染予防剤及び魚介類の幼生の飼育方法
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
US6331554B1 (en) 1997-03-28 2001-12-18 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, compositions containing them, and methods for their use
US6020371A (en) * 1997-03-28 2000-02-01 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds compositions containing them and methods for their use
GB9723407D0 (en) * 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
EP0943624A1 (fr) * 1998-03-12 1999-09-22 Universiteit Utrecht Inhibiteurs peptidiques de la rétrorégulation du récepteur de l'hormone de croissance
HUP0400624A2 (hu) 1998-04-30 2004-06-28 Agouron Pharmaceuticals, Inc. Picornavírus-ellenes vegyületek, előállításuk és alkalmazásuk
CA2360740A1 (fr) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
JP2003514524A (ja) 1999-11-18 2003-04-22 コルバス・インターナショナル・インコーポレイテッド エントセリアーゼをコードしている核酸、エンドセリアーゼおよびその使用
PA8507801A1 (es) 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
AU2001251587A1 (en) * 2000-04-21 2001-11-12 Enanta Pharmaceuticals, Inc. Bifunctional inhibitors of malarial proteases and uses thereof
JP2004503533A (ja) 2000-06-14 2004-02-05 アグロン・ファーマシュウティカルズ・インコーポレーテッド 抗ピコルナウイルス化合物及び組成物、その医薬的使用、並びにその合成のための物質
US20070117785A1 (en) * 2000-08-14 2007-05-24 Butler Christopher R Substituted pyrazoles and methods of treatment with substituted pyrazoles
US20050101587A9 (en) * 2000-08-14 2005-05-12 Butler Christopher R. Method for treating allergies using substituted pyrazoles
AU8645401A (en) 2000-08-14 2002-02-25 Ortho Mcneil Pharm Inc Substituted pyrazoles
EP1309592B9 (fr) 2000-08-14 2007-02-28 Ortho-McNeil Pharmaceutical, Inc. Pyrazoles substitues
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
DK1309591T3 (da) * 2000-08-14 2007-03-26 Ortho Mcneil Pharm Inc Substituerede pyrazoler
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
EP1315966B1 (fr) * 2000-09-06 2007-10-03 Ortho-McNeil Pharmaceutical, Inc. Procede relatif au controle de l'effet d'inhibiteurs de cathepsine s
MXPA03001960A (es) 2000-09-06 2004-03-18 Johnson & Johnson Un metodo para tratar alergias.
ATE510837T1 (de) * 2000-09-13 2011-06-15 Vertex Pharma Caspase inhibitoren und deren verwendung
WO2002048097A1 (fr) * 2000-12-12 2002-06-20 Corvas International, Inc. Composes, compositions et procedes de traitement d'infections parasitaires
DE60120104T2 (de) * 2001-03-20 2006-09-21 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
WO2003016335A2 (fr) * 2001-08-13 2003-02-27 Probiodrug Ag Inhibiteurs irreversibles de la cysteine protease de la legumaine
US6780985B2 (en) 2001-11-08 2004-08-24 Ortho-Mcneil Pharmaceutical, Inc. Polynucleotide and polypeptide sequences of Canine Cathepsin S
US6784288B2 (en) 2001-11-08 2004-08-31 Ortho-Mcneil Pharmaceutical, Inc. Polynucleotide and polypeptide sequences of monkey cathepsin S
MY140707A (en) * 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
US20030125548A1 (en) * 2002-09-13 2003-07-03 Dorit Arad Molecules derived from mechanism based drug design
US20100113328A1 (en) * 2003-05-29 2010-05-06 The Scripps Research Institute Targeted delivery to legumain-expressing cells
EP1919930B1 (fr) * 2005-07-01 2016-09-14 Dako Denmark A/S Paires de bases d'acides nucléiques
MX2008001207A (es) * 2005-07-26 2008-03-24 Merck Frosst Canada Ltd Inhibidores de la cisteina proteasa de la familia de la papaina para el tratamiento de enfermedades parasitarias.
WO2007064759A2 (fr) * 2005-11-29 2007-06-07 The Scripps Research Institute Inhibition de l'invasion des cellules tumorales, de la metastase et de l'angiogenese
SG191591A1 (en) * 2008-05-21 2013-07-31 New World Lab Inc Selective caspase inhibitors and uses thereof
BRPI0921392A2 (pt) 2008-12-05 2016-04-26 Abbott Lab inibidores quinase com perfil de segurança cyp aperfeiçoado
WO2010133000A1 (fr) * 2009-05-21 2010-11-25 New World Laboratories Inc. Inhibiteurs sélectifs des caspases et leurs utilisations
DK2697246T3 (en) 2011-04-15 2018-05-28 Genesis Tech Limited SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
US9670250B2 (en) 2012-04-27 2017-06-06 The Trustees Of The University Of Pennsylvania Alpha-helical peptidomimetic inhibitors and methods using same
EP3781573A4 (fr) * 2018-04-16 2021-12-29 Council of Scientific & Industrial Research Nouveaux composés antipaludiques, leur procédé de préparation et leur utilisation pour le paludisme résistant aux médicaments
WO2021195183A1 (fr) * 2020-03-24 2021-09-30 Exo Therapeutics, Inc. Compositions et procédés pour l'inhibition de l'activité de développement d'ectoderme embryonnaire de protéine et de traitement d'une maladie
US11905249B2 (en) 2021-01-25 2024-02-20 Jackson State University Covalent inhibitors of equine encephalitis virus

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US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
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US5101068A (en) * 1990-02-16 1992-03-31 Prototek Inc. Magnesium fluoromalonates
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US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use

Also Published As

Publication number Publication date
CA2184098A1 (fr) 1995-08-31
NZ282946A (en) 1998-05-27
AU2091095A (en) 1995-09-11
AU708414B2 (en) 1999-08-05
EP0756625A4 (fr) 1999-07-28
US5976858A (en) 1999-11-02
WO1995023222A1 (fr) 1995-08-31
ZA951573B (en) 1995-12-12
US6287840B1 (en) 2001-09-11
EP0756625A1 (fr) 1997-02-05

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