IL112402A - Methods for producing N-alanyl porcine somatotropin and compositions thereof - Google Patents
Methods for producing N-alanyl porcine somatotropin and compositions thereofInfo
- Publication number
- IL112402A IL112402A IL11240286A IL11240286A IL112402A IL 112402 A IL112402 A IL 112402A IL 11240286 A IL11240286 A IL 11240286A IL 11240286 A IL11240286 A IL 11240286A IL 112402 A IL112402 A IL 112402A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- species
- alanine
- producing
- methods
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 3
- 108010051696 Growth Hormone Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 241000894007 species Species 0.000 abstract 3
- 108020004705 Codon Proteins 0.000 abstract 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
- 235000004279 alanine Nutrition 0.000 abstract 2
- 229930182817 methionine Natural products 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 1
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 1
- 239000000854 Human Growth Hormone Substances 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960004532 somatropin Drugs 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/704,362 US4861868A (en) | 1985-02-22 | 1985-02-22 | Production of proteins in procaryotes |
| US06/824,202 US5037806A (en) | 1985-02-22 | 1986-02-04 | Biologically active method using somatotropins |
| IL7795086A IL77950A (en) | 1985-02-22 | 1986-02-21 | Method and preparations for increasing milk production in cattle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL112402A0 IL112402A0 (en) | 1995-03-30 |
| IL112402A true IL112402A (en) | 1997-02-18 |
Family
ID=27107310
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11240386A IL112403A (en) | 1985-02-22 | 1986-02-21 | A method for producing mature growth hormone from cattle at the end of which amine alanine in E.COLI |
| IL11240286A IL112402A (en) | 1985-02-22 | 1986-02-21 | Methods for producing N-alanyl porcine somatotropin and compositions thereof |
| IL7795086A IL77950A (en) | 1985-02-22 | 1986-02-21 | Method and preparations for increasing milk production in cattle |
| IL11240395A IL112403A0 (en) | 1985-02-22 | 1995-01-20 | Method for producing a heterologous polypeptide |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11240386A IL112403A (en) | 1985-02-22 | 1986-02-21 | A method for producing mature growth hormone from cattle at the end of which amine alanine in E.COLI |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL7795086A IL77950A (en) | 1985-02-22 | 1986-02-21 | Method and preparations for increasing milk production in cattle |
| IL11240395A IL112403A0 (en) | 1985-02-22 | 1995-01-20 | Method for producing a heterologous polypeptide |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5037806A (xx) |
| EP (1) | EP0193515B1 (xx) |
| JP (3) | JP2583214B2 (xx) |
| KR (1) | KR920000849B1 (xx) |
| CN (3) | CN1051302A (xx) |
| AT (1) | ATE141327T1 (xx) |
| AU (2) | AU596575B2 (xx) |
| CA (1) | CA1338981C (xx) |
| DE (1) | DE3650553T2 (xx) |
| DK (1) | DK80886A (xx) |
| ES (1) | ES8801851A1 (xx) |
| GR (1) | GR860509B (xx) |
| HU (1) | HU210671B (xx) |
| IE (1) | IE80663B1 (xx) |
| IL (4) | IL112403A (xx) |
| LT (1) | LT3916B (xx) |
| MX (1) | MX9203728A (xx) |
| NO (1) | NO300551B1 (xx) |
| NZ (1) | NZ215260A (xx) |
| PT (1) | PT82070B (xx) |
| RO (1) | RO106956B1 (xx) |
| RU (2) | RU2072393C1 (xx) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692941B1 (en) | 1980-08-26 | 2004-02-17 | The Regents Of The University Of California | Bovine growth hormone |
| US7101981B1 (en) | 1980-08-26 | 2006-09-05 | Regents Of The University Of California | Bovine growth hormone recombinantly produced in E. coli |
| US5141922A (en) * | 1985-02-22 | 1992-08-25 | Monsanto Company | Biologically active proteins and a method for their use |
| US4861868A (en) | 1985-02-22 | 1989-08-29 | Monsanto Company | Production of proteins in procaryotes |
| EP0229110B1 (en) * | 1985-06-26 | 1992-05-20 | The Upjohn Company | Solubilization and oxidation of somatotropin from transformed microorganisms |
| AU599922B2 (en) * | 1985-09-10 | 1990-08-02 | Natinco Nv | Improving carcass quality |
| NZ219789A (en) | 1986-03-27 | 1990-09-26 | Monsanto Co | Method for enhancing protein production in bacteria by employing a specific ribosome binding site |
| GB8701848D0 (en) * | 1987-01-28 | 1987-03-04 | Celltech Ltd | Polypeptides |
| US5104806A (en) * | 1987-03-12 | 1992-04-14 | Amgen, Inc. | Porcine growth hormone analogs encoding dna |
| US5244882A (en) * | 1987-03-12 | 1993-09-14 | Amgen, Inc. | Porcine growth hormone analogs, and compositions |
| US4863736A (en) | 1987-03-16 | 1989-09-05 | Monsanto Company | Somatotropin prolonged release |
| EP0737752A3 (en) * | 1988-02-17 | 1996-10-23 | The Upjohn Company | Fermentation media and methods for controlling norleucine content in polypeptides |
| US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
| US5130422A (en) * | 1988-08-29 | 1992-07-14 | Monsanto Company | Variant somatotropin-encoding DNA |
| KR927003633A (ko) * | 1989-07-10 | 1992-12-18 | 로버트 에이. 아미테이지 | 소마토트로핀 유사체 |
| US5663305A (en) * | 1989-07-10 | 1997-09-02 | The Upjohn Company | Somatotropin analogs |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
| US6583115B1 (en) | 1989-10-12 | 2003-06-24 | Ohio University/Edison Biotechnology Institute | Methods for treating acromegaly and giantism with growth hormone antagonists |
| US5958879A (en) * | 1989-10-12 | 1999-09-28 | Ohio University/Edison Biotechnology Institute | Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US6787336B1 (en) | 1989-10-12 | 2004-09-07 | Ohio University/Edison Biotechnology Institute | DNA encoding growth hormone antagonists |
| US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
| US5767080A (en) * | 1996-05-01 | 1998-06-16 | Cargill, Incorporated | Enhanced milk production in dairy cattle |
| GB9803424D0 (en) * | 1998-02-18 | 1998-04-15 | Pfizer Ltd | Performance enhancement |
| CA2346064A1 (en) | 1998-10-05 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Method for removing n-terminal methionine |
| US6890731B1 (en) * | 2000-03-27 | 2005-05-10 | Applera Corporation | Isolated human G-protein coupled receptors that are members of the aminergic subfamily, nucleic acid molecules encoding human GPCR proteins, and uses thereof |
| CN101665788B (zh) * | 2009-09-21 | 2011-11-09 | 山西大学 | 人工合成猪生长激素基因及其表达纯化方法 |
| CN101907626A (zh) * | 2010-07-20 | 2010-12-08 | 广东省农业科学院兽医研究所 | 一种猪饲料中猪源蛋白的检测方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
| IL59690A (en) | 1980-03-24 | 1983-11-30 | Yeda Res & Dev | Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it |
| IE52755B1 (en) * | 1980-08-26 | 1988-02-17 | Univ California | Bovine pre-growth and growth hormone |
| JPS58996A (ja) * | 1981-06-01 | 1983-01-06 | ザ・ボ−ド・オブ・トラステイ−ズ・ミシガンステ−トユニバ−シテイ− | 細菌中での牛成長ホルモン遺伝子のクロ−ン化 |
| US4436824A (en) * | 1981-06-09 | 1984-03-13 | Ortho Diagnostic Systems, Inc. | Leukocyte migration through antigen containing agaroses for immunocompetence testing |
| EP0085036A1 (en) * | 1982-01-18 | 1983-08-03 | Monsanto Company | Method for improved bovine milk production |
| GB2121054B (en) | 1982-05-25 | 1986-02-26 | Lilly Co Eli | Cloning vectors for expression of exogenous protein |
| CA1224432A (en) * | 1982-08-17 | 1987-07-21 | Gary N. Buell | Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield |
| AU2092983A (en) * | 1982-11-08 | 1984-05-17 | Genentech Inc. | Porcine growth hormone produced by recombinant dna technology |
| EP0111814A3 (en) * | 1982-12-16 | 1985-08-14 | Mgi Pharma, Inc. | The cloning and expression of nucleotide sequences encoding bovine growth hormone |
| US4661454A (en) * | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
| CA1340597C (en) * | 1984-08-27 | 1999-06-22 | Haim Aviv | Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods |
| KR890002631B1 (ko) * | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
| US4861868A (en) * | 1985-02-22 | 1989-08-29 | Monsanto Company | Production of proteins in procaryotes |
-
1986
- 1986-02-04 US US06/824,202 patent/US5037806A/en not_active Expired - Lifetime
- 1986-02-20 ES ES552234A patent/ES8801851A1/es not_active Expired
- 1986-02-21 IL IL11240386A patent/IL112403A/en not_active IP Right Cessation
- 1986-02-21 AT AT86870024T patent/ATE141327T1/de not_active IP Right Cessation
- 1986-02-21 NZ NZ215260A patent/NZ215260A/xx unknown
- 1986-02-21 DK DK80886A patent/DK80886A/da unknown
- 1986-02-21 PT PT82070A patent/PT82070B/pt not_active IP Right Cessation
- 1986-02-21 IL IL11240286A patent/IL112402A/xx not_active IP Right Cessation
- 1986-02-21 RO RO133757A patent/RO106956B1/ro unknown
- 1986-02-21 DE DE3650553T patent/DE3650553T2/de not_active Expired - Fee Related
- 1986-02-21 CA CA000502495A patent/CA1338981C/en not_active Expired - Lifetime
- 1986-02-21 CN CN90108714A patent/CN1051302A/zh active Pending
- 1986-02-21 GR GR860509A patent/GR860509B/el unknown
- 1986-02-21 KR KR1019860001221A patent/KR920000849B1/ko not_active IP Right Cessation
- 1986-02-21 JP JP61037158A patent/JP2583214B2/ja not_active Expired - Fee Related
- 1986-02-21 IL IL7795086A patent/IL77950A/en not_active IP Right Cessation
- 1986-02-21 AU AU53854/86A patent/AU596575B2/en not_active Ceased
- 1986-02-21 HU HU86742A patent/HU210671B/hu not_active IP Right Cessation
- 1986-02-21 EP EP86870024A patent/EP0193515B1/en not_active Expired - Lifetime
- 1986-02-21 NO NO860658A patent/NO300551B1/no not_active IP Right Cessation
- 1986-02-21 CN CN86101830A patent/CN1021973C/zh not_active Expired - Lifetime
- 1986-02-24 IE IE46786A patent/IE80663B1/en not_active IP Right Cessation
-
1989
- 1989-10-13 AU AU42825/89A patent/AU632293B2/en not_active Ceased
-
1990
- 1990-08-20 RU SU4830848/13A patent/RU2072393C1/ru not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203728A patent/MX9203728A/es active IP Right Grant
- 1992-08-03 RU SU5052718/13A patent/RU2094439C1/ru not_active IP Right Cessation
-
1994
- 1994-01-28 LT LTIP1819A patent/LT3916B/lt not_active IP Right Cessation
- 1994-05-10 CN CN94105667A patent/CN1100272A/zh active Pending
-
1995
- 1995-01-20 IL IL11240395A patent/IL112403A0/xx unknown
- 1995-05-26 JP JP7128636A patent/JP2863113B2/ja not_active Expired - Fee Related
- 1995-05-26 JP JP7128637A patent/JP2634390B2/ja not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| EXP | Patent expired |