IL112243A - Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them - Google Patents

Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112243A
IL112243A IL11224395A IL11224395A IL112243A IL 112243 A IL112243 A IL 112243A IL 11224395 A IL11224395 A IL 11224395A IL 11224395 A IL11224395 A IL 11224395A IL 112243 A IL112243 A IL 112243A
Authority
IL
Israel
Prior art keywords
fribinogen
benzazepine
benzodiazepine
antagonists
preparation
Prior art date
Application number
IL11224395A
Other languages
English (en)
Other versions
IL112243A0 (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IL112243A0 publication Critical patent/IL112243A0/xx
Publication of IL112243A publication Critical patent/IL112243A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
IL11224395A 1994-01-07 1995-01-04 Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them IL112243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17901194A 1994-01-07 1994-01-07

Publications (2)

Publication Number Publication Date
IL112243A0 IL112243A0 (en) 1995-03-30
IL112243A true IL112243A (en) 1999-12-31

Family

ID=22654859

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11224395A IL112243A (en) 1994-01-07 1995-01-04 Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US6117866A (zh)
EP (1) EP0738150B1 (zh)
JP (1) JPH09508620A (zh)
KR (1) KR100388772B1 (zh)
CN (1) CN1117569C (zh)
AP (1) AP542A (zh)
AT (1) ATE238993T1 (zh)
AU (1) AU699186B2 (zh)
BG (2) BG62844B1 (zh)
BR (1) BR9506499A (zh)
CZ (1) CZ292323B6 (zh)
DE (1) DE69530571T2 (zh)
DK (1) DK0738150T3 (zh)
ES (1) ES2197914T3 (zh)
HK (1) HK1014668A1 (zh)
HU (1) HUT76282A (zh)
IL (1) IL112243A (zh)
MA (1) MA23420A1 (zh)
NO (1) NO962859L (zh)
NZ (1) NZ279394A (zh)
OA (1) OA10368A (zh)
PT (1) PT738150E (zh)
SG (1) SG64884A1 (zh)
SK (1) SK86996A3 (zh)
TW (1) TW420682B (zh)
WO (1) WO1995018619A1 (zh)
ZA (1) ZA9545B (zh)

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JPH10504825A (ja) * 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
DE19516483A1 (de) 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ZA9610853B (en) 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
IL128782A0 (en) * 1996-09-03 2000-01-31 Smithkline Beecham Corp Crystalline pharmaceutical product
EP0964928A1 (en) * 1996-12-27 1999-12-22 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase
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US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
WO2000035887A2 (en) 1998-12-18 2000-06-22 Du Pont Pharm Co Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
GB9908662D0 (en) * 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel process for preparing benzodiazepines
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
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US6964974B2 (en) 2000-09-08 2005-11-15 Hoffmann-La Roche Inc. 2,3-oxidosqualene-lanosterol cyclase inhibitors
DK1560584T3 (da) 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
WO2003059251A2 (en) 2001-10-22 2003-07-24 The Scripps Research Institute Antibody targeting compounds
AU2003301346A1 (en) * 2002-10-17 2004-05-04 The Trustees Of The University Of Pennsylvania Method of treating neurological diseases and disorders
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625333A1 (en) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
US7759387B2 (en) 2003-10-08 2010-07-20 Piramal Life Sciences Limited Fibrinogen receptor antagonists and their use
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
CA2630415A1 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
US8518927B2 (en) 2009-02-10 2013-08-27 The Scripps Research Institute Chemically programmed vaccination
IN2014KN02915A (zh) 2012-06-19 2015-05-08 Debiopharm Int Sa
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections

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Also Published As

Publication number Publication date
BG102863A (en) 1999-05-31
BG100698A (bg) 1997-02-28
ATE238993T1 (de) 2003-05-15
KR100388772B1 (ko) 2003-11-20
CZ292323B6 (cs) 2003-09-17
TW420682B (en) 2001-02-01
MA23420A1 (fr) 1995-10-01
CN1143323A (zh) 1997-02-19
SK86996A3 (en) 1997-02-05
NO962859L (no) 1996-09-05
HK1014668A1 (en) 1999-09-30
OA10368A (en) 2001-11-15
HU9601849D0 (en) 1996-09-30
AP9500710A0 (en) 1995-01-31
DE69530571D1 (de) 2003-06-05
WO1995018619A1 (en) 1995-07-13
BG62844B1 (bg) 2000-09-29
SG64884A1 (en) 1999-05-25
BR9506499A (pt) 1997-09-09
WO1995018619A9 (en) 2004-10-21
CZ198196A3 (en) 1997-06-11
ES2197914T3 (es) 2004-01-16
AU699186B2 (en) 1998-11-26
AU1600195A (en) 1995-08-01
ZA9545B (en) 1996-01-23
NO962859D0 (no) 1996-07-05
EP0738150A1 (en) 1996-10-23
IL112243A0 (en) 1995-03-30
JPH09508620A (ja) 1997-09-02
AP542A (en) 1996-10-01
EP0738150A4 (en) 1997-03-19
HUT76282A (en) 1997-07-28
DK0738150T3 (da) 2003-08-25
NZ279394A (en) 1998-05-27
US6117866A (en) 2000-09-12
DE69530571T2 (de) 2004-03-04
CN1117569C (zh) 2003-08-13
EP0738150B1 (en) 2003-05-02
PT738150E (pt) 2003-08-29

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