IL111066A - Process for the preparation of 9-amino camptothecin novel substituted 9-nitrocamptothecin derivatives thereof their preparation and pharmaceutical compositions containing them - Google Patents
Process for the preparation of 9-amino camptothecin novel substituted 9-nitrocamptothecin derivatives thereof their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL111066A IL111066A IL11106694A IL11106694A IL111066A IL 111066 A IL111066 A IL 111066A IL 11106694 A IL11106694 A IL 11106694A IL 11106694 A IL11106694 A IL 11106694A IL 111066 A IL111066 A IL 111066A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- preparation
- compound
- chem
- nitrocamptothecin
- Prior art date
Links
- FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical class C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
- F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN A CARRIER GAS OR AIR
- F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
- F23C5/02—Structural details of mounting
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12007394A IL120073A (en) | 1993-09-28 | 1994-09-26 | Substituted 9-amino camptothecin compounds their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939319944A GB9319944D0 (en) | 1993-09-28 | 1993-09-28 | Process for the preparation of 9-amino camptothecin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL111066A0 IL111066A0 (en) | 1994-12-29 |
| IL111066A true IL111066A (en) | 1999-12-31 |
Family
ID=10742611
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11106694A IL111066A (en) | 1993-09-28 | 1994-09-26 | Process for the preparation of 9-amino camptothecin novel substituted 9-nitrocamptothecin derivatives thereof their preparation and pharmaceutical compositions containing them |
| IL12007394A IL120073A (en) | 1993-09-28 | 1994-09-26 | Substituted 9-amino camptothecin compounds their preparation and pharmaceutical compositions containing them |
| IL12007397A IL120073A0 (en) | 1993-09-28 | 1997-01-24 | Substituted 9-amino camptothecin compounds their preparation and pharmaceutical compositions containing them |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12007394A IL120073A (en) | 1993-09-28 | 1994-09-26 | Substituted 9-amino camptothecin compounds their preparation and pharmaceutical compositions containing them |
| IL12007397A IL120073A0 (en) | 1993-09-28 | 1997-01-24 | Substituted 9-amino camptothecin compounds their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5614628A (da) |
| EP (2) | EP0670839B1 (da) |
| JP (3) | JP3754068B2 (da) |
| KR (1) | KR950704323A (da) |
| CN (2) | CN1046283C (da) |
| AT (2) | ATE189221T1 (da) |
| AU (1) | AU676089B2 (da) |
| CA (1) | CA2150382C (da) |
| DE (2) | DE69422795T2 (da) |
| DK (2) | DK0982307T3 (da) |
| ES (2) | ES2144059T3 (da) |
| FI (1) | FI952549A7 (da) |
| GB (1) | GB9319944D0 (da) |
| GR (1) | GR3033197T3 (da) |
| HU (1) | HUT71267A (da) |
| IL (3) | IL111066A (da) |
| MY (1) | MY131618A (da) |
| PT (2) | PT670839E (da) |
| RU (1) | RU2137774C1 (da) |
| WO (1) | WO1995009169A1 (da) |
| ZA (1) | ZA947522B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9410388D0 (en) * | 1994-05-24 | 1994-07-13 | Erba Carlo Spa | Method for the preparation of 9-amino camptothecin |
| TW438775B (en) * | 1995-04-07 | 2001-06-07 | Pharmacia & Upjohn Co Llc | Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds |
| US6504029B1 (en) * | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
| GB9600438D0 (en) * | 1996-01-10 | 1996-03-13 | Pharmacia Spa | Hexacyclic camptothecin analogues, and process for preparing them |
| US5731316A (en) * | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| GB9601779D0 (en) * | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
| US6395541B1 (en) | 1996-05-23 | 2002-05-28 | The Rockefeller University | Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I |
| GB9702807D0 (en) | 1997-02-12 | 1997-04-02 | Pharmacia & Upjohn Spa | Alkynyl-substituted camptothecins and process for their preparation |
| GB9715821D0 (en) * | 1997-07-25 | 1997-10-01 | Pharmacia & Upjohn Spa | Amidino-camptothecin derivatives |
| USRE38408E1 (en) | 1997-08-05 | 2004-01-27 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| US5922877A (en) * | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6756381B2 (en) * | 2002-02-21 | 2004-06-29 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof |
| CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9－硝基喜树碱的生产方法 |
| US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
| CN1312155C (zh) * | 2005-01-21 | 2007-04-25 | 华东理工大学 | 一种分离纯化9－硝基喜树碱的方法 |
| CN102470237A (zh) | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | 用于可植入药物递送装置的固体药物片剂 |
| JP2024033912A (ja) * | 2022-08-31 | 2024-03-13 | トヨタ自動車株式会社 | 銀ナノ粒子の製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| GB9316352D0 (en) * | 1993-08-06 | 1993-09-22 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
-
1993
- 1993-09-28 GB GB939319944A patent/GB9319944D0/en active Pending
-
1994
- 1994-09-15 DK DK99202203T patent/DK0982307T3/da active
- 1994-09-15 AT AT94927618T patent/ATE189221T1/de not_active IP Right Cessation
- 1994-09-15 AU AU76969/94A patent/AU676089B2/en not_active Ceased
- 1994-09-15 FI FI952549A patent/FI952549A7/fi unknown
- 1994-09-15 RU RU95112485A patent/RU2137774C1/ru active
- 1994-09-15 KR KR1019950702120A patent/KR950704323A/ko not_active Ceased
- 1994-09-15 DE DE69422795T patent/DE69422795T2/de not_active Expired - Fee Related
- 1994-09-15 CN CN94190731A patent/CN1046283C/zh not_active Expired - Fee Related
- 1994-09-15 ES ES94927618T patent/ES2144059T3/es not_active Expired - Lifetime
- 1994-09-15 DE DE69431856T patent/DE69431856T2/de not_active Expired - Fee Related
- 1994-09-15 PT PT94927618T patent/PT670839E/pt unknown
- 1994-09-15 DK DK94927618T patent/DK0670839T3/da active
- 1994-09-15 AT AT99202203T patent/ATE229022T1/de not_active IP Right Cessation
- 1994-09-15 PT PT99202203T patent/PT982307E/pt unknown
- 1994-09-15 HU HU9501898A patent/HUT71267A/hu unknown
- 1994-09-15 JP JP51008495A patent/JP3754068B2/ja not_active Expired - Fee Related
- 1994-09-15 CA CA002150382A patent/CA2150382C/en not_active Expired - Fee Related
- 1994-09-15 EP EP94927618A patent/EP0670839B1/en not_active Expired - Lifetime
- 1994-09-15 EP EP99202203A patent/EP0982307B1/en not_active Expired - Lifetime
- 1994-09-15 WO PCT/EP1994/003098 patent/WO1995009169A1/en not_active Ceased
- 1994-09-15 ES ES99202203T patent/ES2189345T3/es not_active Expired - Lifetime
- 1994-09-26 IL IL11106694A patent/IL111066A/xx not_active IP Right Cessation
- 1994-09-26 IL IL12007394A patent/IL120073A/xx not_active IP Right Cessation
- 1994-09-27 ZA ZA947522A patent/ZA947522B/xx unknown
- 1994-09-28 MY MYPI94002582A patent/MY131618A/en unknown
- 1994-09-28 US US08/313,906 patent/US5614628A/en not_active Expired - Fee Related
-
1996
- 1996-12-31 US US08/775,605 patent/US5916897A/en not_active Expired - Fee Related
-
1997
- 1997-01-24 IL IL12007397A patent/IL120073A0/xx unknown
-
1999
- 1999-01-06 CN CN99100920A patent/CN1273974A/zh active Pending
-
2000
- 2000-04-12 GR GR20000400891T patent/GR3033197T3/el not_active IP Right Cessation
-
2004
- 2004-07-14 JP JP2004206842A patent/JP2005036004A/ja not_active Withdrawn
- 2004-07-14 JP JP2004206841A patent/JP2005036003A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |