DE69422795T2 - Verfahren zur herstellung von 9-amino camptothecin - Google Patents

Verfahren zur herstellung von 9-amino camptothecin

Info

Publication number
DE69422795T2
DE69422795T2 DE69422795T DE69422795T DE69422795T2 DE 69422795 T2 DE69422795 T2 DE 69422795T2 DE 69422795 T DE69422795 T DE 69422795T DE 69422795 T DE69422795 T DE 69422795T DE 69422795 T2 DE69422795 T2 DE 69422795T2
Authority
DE
Germany
Prior art keywords
formula
compound
chem
group
amino camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69422795T
Other languages
English (en)
Other versions
DE69422795D1 (de
Inventor
Walter Cabri
Ilaria Candiani
Franco Zarini
Angelo Bedeschi
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of DE69422795D1 publication Critical patent/DE69422795D1/de
Application granted granted Critical
Publication of DE69422795T2 publication Critical patent/DE69422795T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
    • F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN  A CARRIER GAS OR AIR 
    • F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
    • F23C5/02—Structural details of mounting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69422795T 1993-09-28 1994-09-15 Verfahren zur herstellung von 9-amino camptothecin Expired - Fee Related DE69422795T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319944A GB9319944D0 (en) 1993-09-28 1993-09-28 Process for the preparation of 9-amino camptothecin
PCT/EP1994/003098 WO1995009169A1 (en) 1993-09-28 1994-09-15 Process for the preparation of 9-amino camptothecin

Publications (2)

Publication Number Publication Date
DE69422795D1 DE69422795D1 (de) 2000-03-02
DE69422795T2 true DE69422795T2 (de) 2000-07-20

Family

ID=10742611

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69422795T Expired - Fee Related DE69422795T2 (de) 1993-09-28 1994-09-15 Verfahren zur herstellung von 9-amino camptothecin
DE69431856T Expired - Fee Related DE69431856T2 (de) 1993-09-28 1994-09-15 9-Amino und 9-Nitrocamptothecinderivate, Verfahren zu ihrer Herstellung unf ihre Verwendung als Antitumormittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69431856T Expired - Fee Related DE69431856T2 (de) 1993-09-28 1994-09-15 9-Amino und 9-Nitrocamptothecinderivate, Verfahren zu ihrer Herstellung unf ihre Verwendung als Antitumormittel

Country Status (21)

Country Link
US (2) US5614628A (de)
EP (2) EP0982307B1 (de)
JP (3) JP3754068B2 (de)
KR (1) KR950704323A (de)
CN (2) CN1046283C (de)
AT (2) ATE229022T1 (de)
AU (1) AU676089B2 (de)
CA (1) CA2150382C (de)
DE (2) DE69422795T2 (de)
DK (2) DK0670839T3 (de)
ES (2) ES2189345T3 (de)
FI (1) FI952549A (de)
GB (1) GB9319944D0 (de)
GR (1) GR3033197T3 (de)
HU (1) HUT71267A (de)
IL (3) IL111066A (de)
MY (1) MY131618A (de)
PT (2) PT982307E (de)
RU (1) RU2137774C1 (de)
WO (1) WO1995009169A1 (de)
ZA (1) ZA947522B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
GB9600438D0 (en) * 1996-01-10 1996-03-13 Pharmacia Spa Hexacyclic camptothecin analogues, and process for preparing them
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US6395541B1 (en) 1996-05-23 2002-05-28 The Rockefeller University Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en) 1997-08-05 2004-01-27 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
EP1229934B1 (de) 1999-10-01 2014-03-05 Immunogen, Inc. Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien
US6756381B2 (en) * 2002-02-21 2004-06-29 Supergen, Inc. Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
CN1312155C (zh) * 2005-01-21 2007-04-25 华东理工大学 一种分离纯化9－硝基喜树碱的方法
WO2010151893A1 (en) 2009-06-26 2010-12-29 Taris Biomedical, Inc. Implantable drug delivery devices and methods of making the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316352D0 (en) * 1993-08-06 1993-09-22 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
JP2005036004A (ja) 2005-02-10
DE69422795D1 (de) 2000-03-02
EP0982307A2 (de) 2000-03-01
DK0982307T3 (da) 2003-03-24
EP0982307A3 (de) 2000-07-26
DE69431856T2 (de) 2003-08-21
CN1046283C (zh) 1999-11-10
ATE229022T1 (de) 2002-12-15
CN1273974A (zh) 2000-11-22
AU676089B2 (en) 1997-02-27
GB9319944D0 (en) 1993-11-17
ES2144059T3 (es) 2000-06-01
WO1995009169A1 (en) 1995-04-06
FI952549A0 (fi) 1995-05-24
CN1115181A (zh) 1996-01-17
MY131618A (en) 2007-08-30
IL111066A0 (en) 1994-12-29
PT670839E (pt) 2000-05-31
IL120073A (en) 1999-07-14
CA2150382A1 (en) 1995-04-06
GR3033197T3 (en) 2000-08-31
AU7696994A (en) 1995-04-18
CA2150382C (en) 2006-12-05
EP0982307B1 (de) 2002-12-04
DE69431856D1 (de) 2003-01-16
EP0670839B1 (de) 2000-01-26
ES2189345T3 (es) 2003-07-01
ATE189221T1 (de) 2000-02-15
JP3754068B2 (ja) 2006-03-08
JPH08506834A (ja) 1996-07-23
RU2137774C1 (ru) 1999-09-20
KR950704323A (ko) 1995-11-17
DK0670839T3 (da) 2002-12-23
HUT71267A (en) 1995-11-28
FI952549A (fi) 1995-07-21
US5614628A (en) 1997-03-25
PT982307E (pt) 2003-04-30
IL111066A (en) 1999-12-31
ZA947522B (en) 1995-05-29
RU95112485A (ru) 1997-04-20
IL120073A0 (en) 1997-04-15
EP0670839A1 (de) 1995-09-13
HU9501898D0 (en) 1995-08-28
US5916897A (en) 1999-06-29
JP2005036003A (ja) 2005-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee