IL110689A - Vasodilators containing aryloxylalkyldiamine, certain new compounds and their preparation - Google Patents
Vasodilators containing aryloxylalkyldiamine, certain new compounds and their preparationInfo
- Publication number
- IL110689A IL110689A IL11068994A IL11068994A IL110689A IL 110689 A IL110689 A IL 110689A IL 11068994 A IL11068994 A IL 11068994A IL 11068994 A IL11068994 A IL 11068994A IL 110689 A IL110689 A IL 110689A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- formula
- 6alkyl
- compound
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93202444 | 1993-08-19 | ||
EP93202445 | 1993-08-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL110689A0 IL110689A0 (en) | 1994-11-11 |
IL110689A true IL110689A (en) | 1998-12-27 |
Family
ID=26133971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11068994A IL110689A (en) | 1993-08-19 | 1994-08-17 | Vasodilators containing aryloxylalkyldiamine, certain new compounds and their preparation |
Country Status (21)
Country | Link |
---|---|
US (2) | US5677310A (sk) |
EP (1) | EP0714388B1 (sk) |
JP (1) | JP3659969B2 (sk) |
KR (1) | KR100345046B1 (sk) |
CN (1) | CN1066718C (sk) |
AT (1) | ATE165091T1 (sk) |
AU (1) | AU682396B2 (sk) |
BR (1) | BR9407313A (sk) |
CA (1) | CA2168023C (sk) |
CZ (1) | CZ39396A3 (sk) |
DE (1) | DE69409652T2 (sk) |
FI (1) | FI120145B (sk) |
HU (1) | HU222275B1 (sk) |
IL (1) | IL110689A (sk) |
NO (1) | NO305283B1 (sk) |
NZ (1) | NZ271994A (sk) |
PL (1) | PL179008B1 (sk) |
RU (1) | RU2158126C2 (sk) |
SK (1) | SK21596A3 (sk) |
WO (1) | WO1995005366A1 (sk) |
ZA (1) | ZA946270B (sk) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9507288D0 (en) * | 1995-04-07 | 1995-05-31 | Sod Conseils Rech Applic | Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors |
FR2753967B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
CA2581623A1 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
PT2200985E (pt) | 2007-09-14 | 2011-07-21 | Ortho Mcneil Janssen Pharm | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
KR101533440B1 (ko) | 2007-09-14 | 2015-07-03 | 얀센 파마슈티칼스 인코포레이티드 | 1´,3´-이치환된-4-페닐-3,4,5,6-테트라히드로-2h,1´h-[1,4´]비피리디닐-2´-온 |
TW200927731A (en) * | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
SG176021A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
MX370535B (es) | 2013-11-18 | 2019-12-17 | Forma Therapeutics Inc | Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer. |
EP3071205B1 (en) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
UA128346C2 (uk) | 2014-01-21 | 2024-06-19 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
US5231166A (en) * | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
FR2675799B1 (fr) * | 1991-04-24 | 1993-12-24 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
FR2697253B1 (fr) * | 1992-10-22 | 1994-12-02 | Synthelabo | Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. |
-
1994
- 1994-08-12 SK SK215-96A patent/SK21596A3/sk unknown
- 1994-08-12 JP JP50675195A patent/JP3659969B2/ja not_active Expired - Lifetime
- 1994-08-12 EP EP94926190A patent/EP0714388B1/en not_active Expired - Lifetime
- 1994-08-12 PL PL94313081A patent/PL179008B1/pl unknown
- 1994-08-12 NZ NZ271994A patent/NZ271994A/en not_active IP Right Cessation
- 1994-08-12 CZ CZ96393A patent/CZ39396A3/cs unknown
- 1994-08-12 AU AU76130/94A patent/AU682396B2/en not_active Expired
- 1994-08-12 RU RU96105988/14A patent/RU2158126C2/ru active
- 1994-08-12 CN CN94193180A patent/CN1066718C/zh not_active Expired - Lifetime
- 1994-08-12 BR BR9407313A patent/BR9407313A/pt not_active Application Discontinuation
- 1994-08-12 WO PCT/EP1994/002702 patent/WO1995005366A1/en not_active Application Discontinuation
- 1994-08-12 AT AT94926190T patent/ATE165091T1/de not_active IP Right Cessation
- 1994-08-12 DE DE69409652T patent/DE69409652T2/de not_active Expired - Lifetime
- 1994-08-12 KR KR1019960700634A patent/KR100345046B1/ko not_active IP Right Cessation
- 1994-08-12 CA CA002168023A patent/CA2168023C/en not_active Expired - Lifetime
- 1994-08-12 HU HU9600349A patent/HU222275B1/hu active IP Right Grant
- 1994-08-12 US US08/612,849 patent/US5677310A/en not_active Expired - Lifetime
- 1994-08-17 IL IL11068994A patent/IL110689A/en not_active IP Right Cessation
- 1994-08-18 ZA ZA946270A patent/ZA946270B/xx unknown
-
1996
- 1996-02-16 FI FI960722A patent/FI120145B/fi not_active IP Right Cessation
- 1996-02-19 NO NO960648A patent/NO305283B1/no not_active IP Right Cessation
-
1997
- 1997-06-02 US US08/867,870 patent/US5801179A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI960722A (fi) | 1996-02-16 |
FI960722A0 (fi) | 1996-02-16 |
JPH09502962A (ja) | 1997-03-25 |
AU682396B2 (en) | 1997-10-02 |
NO960648L (no) | 1996-02-19 |
CN1129935A (zh) | 1996-08-28 |
US5801179A (en) | 1998-09-01 |
FI120145B (fi) | 2009-07-15 |
KR100345046B1 (ko) | 2002-12-05 |
DE69409652D1 (de) | 1998-05-20 |
CA2168023C (en) | 2006-10-24 |
WO1995005366A1 (en) | 1995-02-23 |
NZ271994A (en) | 1997-06-24 |
EP0714388B1 (en) | 1998-04-15 |
RU2158126C2 (ru) | 2000-10-27 |
HU222275B1 (hu) | 2003-05-28 |
AU7613094A (en) | 1995-03-14 |
ATE165091T1 (de) | 1998-05-15 |
JP3659969B2 (ja) | 2005-06-15 |
PL313081A1 (en) | 1996-05-27 |
HU9600349D0 (en) | 1996-04-29 |
EP0714388A1 (en) | 1996-06-05 |
CN1066718C (zh) | 2001-06-06 |
PL179008B1 (pl) | 2000-07-31 |
CZ39396A3 (en) | 1996-05-15 |
CA2168023A1 (en) | 1995-02-23 |
NO305283B1 (no) | 1999-05-03 |
HUT73977A (en) | 1996-10-28 |
BR9407313A (pt) | 1996-10-08 |
SK21596A3 (en) | 1997-03-05 |
ZA946270B (en) | 1996-02-19 |
NO960648D0 (no) | 1996-02-19 |
IL110689A0 (en) | 1994-11-11 |
US5677310A (en) | 1997-10-14 |
DE69409652T2 (de) | 1998-10-15 |
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |