IL107333A - Trisubstituted biphenyls, their preparation and pharmaceutical compositions containing them - Google Patents

Trisubstituted biphenyls, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL107333A
IL107333A IL107333A IL10733393A IL107333A IL 107333 A IL107333 A IL 107333A IL 107333 A IL107333 A IL 107333A IL 10733393 A IL10733393 A IL 10733393A IL 107333 A IL107333 A IL 107333A
Authority
IL
Israel
Prior art keywords
mmol
carboxyl
compound
radical
solution
Prior art date
Application number
IL107333A
Other languages
English (en)
Other versions
IL107333A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL107333A0 publication Critical patent/IL107333A0/xx
Publication of IL107333A publication Critical patent/IL107333A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
IL107333A 1992-10-23 1993-10-20 Trisubstituted biphenyls, their preparation and pharmaceutical compositions containing them IL107333A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235933 1992-10-23
DE4319041A DE4319041A1 (de) 1992-10-23 1993-06-08 Trisubstituierte Biphenyle

Publications (2)

Publication Number Publication Date
IL107333A0 IL107333A0 (en) 1994-01-25
IL107333A true IL107333A (en) 1998-01-04

Family

ID=25919778

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107333A IL107333A (en) 1992-10-23 1993-10-20 Trisubstituted biphenyls, their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US5596006A (cs)
EP (1) EP0594019B1 (cs)
JP (1) JPH06199838A (cs)
KR (1) KR100304225B1 (cs)
CN (1) CN1040435C (cs)
AT (1) ATE189893T1 (cs)
AU (1) AU670315B2 (cs)
CA (1) CA2108814A1 (cs)
CZ (1) CZ283482B6 (cs)
DE (2) DE4319041A1 (cs)
DK (1) DK0594019T3 (cs)
ES (1) ES2145021T3 (cs)
FI (1) FI934646A7 (cs)
GR (1) GR3033207T3 (cs)
HU (1) HUT65819A (cs)
IL (1) IL107333A (cs)
MX (1) MX9306419A (cs)
NO (1) NO304651B1 (cs)
NZ (1) NZ250002A (cs)
PT (1) PT594019E (cs)
SK (1) SK279675B6 (cs)
TW (1) TW248555B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
EP1310488A4 (en) * 2000-08-09 2005-08-10 Mitsubishi Pharma Corp CONDENSED BICYCLIC AMIDE COMPOUNDS AND MEDICAL USES THEREOF
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (en) * 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
ES2251292B1 (es) * 2004-04-20 2007-07-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis.
WO2006130901A1 (en) * 2005-06-07 2006-12-14 Bayer Healthcare Ag Control of metabolic abnormalities
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
SI2847228T1 (sl) 2012-05-10 2018-11-30 Bayer Pharma Aktiengesellschaft Protitelesa zmožna vezave na faktor koagulacije XI in/ali njeno aktivirano obliko faktor XIa in njihove uporabe
KR102614588B1 (ko) 2018-08-20 2023-12-18 삼성디스플레이 주식회사 표시 장치의 제조 방법
WO2024159724A1 (zh) * 2023-02-03 2024-08-08 科莱博(江苏)科技股份有限公司 一种邻联苯基噁唑啉化合物及其合成方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
DE10075018I2 (de) * 1989-06-14 2001-08-09 Smithkline Beecham Corp Imidazoalkensäure.
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0485410A1 (en) * 1989-07-06 1992-05-20 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern A detector for monitoring low molecular weight compounds
CA2027937A1 (en) * 1989-10-25 1991-04-26 Richard M. Keenan Substituted 5-¬ (tetrazolyl)alkenyl|imidazoles
WO1991009697A1 (en) * 1989-12-25 1991-07-11 Nippon Steel Corporation Sheet of titanium-aluminum intermetallic compound and process for producing the same
EP0453210A3 (en) * 1990-04-19 1993-01-13 Imperial Chemical Industries Plc Pyridine derivatives
CN1034934C (zh) * 1990-06-19 1997-05-21 明治制果株式会社 血管紧张素ii拮抗性吡啶衍生物的制备方法
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
ATE250043T1 (de) * 1991-11-18 2003-10-15 Du Pont Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle

Also Published As

Publication number Publication date
NZ250002A (en) 1995-03-28
AU4754193A (en) 1994-05-05
DK0594019T3 (da) 2000-07-03
ATE189893T1 (de) 2000-03-15
CA2108814A1 (en) 1994-04-24
AU670315B2 (en) 1996-07-11
PT594019E (pt) 2000-08-31
KR100304225B1 (ko) 2004-05-10
CZ283482B6 (cs) 1998-04-15
DE59309956D1 (de) 2000-03-30
EP0594019B1 (de) 2000-02-23
HUT65819A (en) 1994-07-28
GR3033207T3 (en) 2000-08-31
US5596006A (en) 1997-01-21
MX9306419A (es) 1994-05-31
NO304651B1 (no) 1999-01-25
FI934646L (fi) 1994-04-24
SK279675B6 (sk) 1999-02-11
KR940009174A (ko) 1994-05-20
TW248555B (cs) 1995-06-01
CZ221793A3 (en) 1994-05-18
IL107333A0 (en) 1994-01-25
CN1040435C (zh) 1998-10-28
EP0594019A1 (de) 1994-04-27
US5863930A (en) 1999-01-26
JPH06199838A (ja) 1994-07-19
FI934646A0 (fi) 1993-10-21
CN1089260A (zh) 1994-07-13
FI934646A7 (fi) 1994-04-24
DE4319041A1 (de) 1994-04-28
HU9302997D0 (en) 1994-01-28
SK116993A3 (en) 1994-11-09
NO933591L (no) 1994-04-25
NO933591D0 (no) 1993-10-07
ES2145021T3 (es) 2000-07-01

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Legal Events

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KB Patent renewed
KB Patent renewed
RH1 Patent not in force