IL106641A - Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them - Google Patents
Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing themInfo
- Publication number
- IL106641A IL106641A IL10664193A IL10664193A IL106641A IL 106641 A IL106641 A IL 106641A IL 10664193 A IL10664193 A IL 10664193A IL 10664193 A IL10664193 A IL 10664193A IL 106641 A IL106641 A IL 106641A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- compound
- cyano
- pyridyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92979592A | 1992-08-13 | 1992-08-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106641A0 IL106641A0 (en) | 1993-12-08 |
| IL106641A true IL106641A (en) | 2001-01-11 |
Family
ID=25458467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10664193A IL106641A (en) | 1992-08-13 | 1993-08-10 | Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5567722A (enExample) |
| EP (1) | EP0655057B1 (enExample) |
| JP (1) | JPH08500111A (enExample) |
| CN (1) | CN1039997C (enExample) |
| AT (1) | ATE158279T1 (enExample) |
| AU (2) | AU4530693A (enExample) |
| DE (1) | DE69314041T2 (enExample) |
| DK (1) | DK0655057T3 (enExample) |
| ES (1) | ES2107049T3 (enExample) |
| GR (1) | GR3025640T3 (enExample) |
| IL (1) | IL106641A (enExample) |
| MX (1) | MX9304882A (enExample) |
| MY (1) | MY110826A (enExample) |
| TW (1) | TW223017B (enExample) |
| WO (2) | WO1994004499A1 (enExample) |
| ZA (1) | ZA935619B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2179036A1 (en) * | 1994-01-28 | 1995-08-03 | Stephen J. Humphrey | Cyanoguanidines as k-channel blockers |
| AUPN193095A0 (en) * | 1995-03-24 | 1995-04-27 | Polychip Pharmaceuticals Pty Ltd | Potassium ion channel blockers |
| AR008290A1 (es) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
| JP2000516620A (ja) * | 1996-08-15 | 2000-12-12 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
| GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
| CN113683535B (zh) * | 2020-05-18 | 2022-08-30 | 中国药科大学 | 含氰胍结构的化合物及其制备方法与用途 |
| CN112042664B (zh) * | 2020-09-18 | 2022-06-10 | 广州古神生物科技有限公司 | 防霉抗菌剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
| JPH01166119A (ja) * | 1987-12-23 | 1989-06-30 | Hitachi Ltd | データ入力装置の制御方式 |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| PT93033B (pt) * | 1989-02-03 | 1996-03-29 | Lilly Co Eli | Processo para a preparacao de derivados de guanidina |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
-
1993
- 1993-06-11 WO PCT/US1993/005458 patent/WO1994004499A1/en not_active Ceased
- 1993-06-11 AU AU45306/93A patent/AU4530693A/en not_active Abandoned
- 1993-07-21 DK DK93917262.3T patent/DK0655057T3/da active
- 1993-07-21 AU AU46831/93A patent/AU4683193A/en not_active Abandoned
- 1993-07-21 JP JP6506258A patent/JPH08500111A/ja active Pending
- 1993-07-21 DE DE69314041T patent/DE69314041T2/de not_active Expired - Fee Related
- 1993-07-21 WO PCT/US1993/006752 patent/WO1994004500A1/en not_active Ceased
- 1993-07-21 EP EP93917262A patent/EP0655057B1/en not_active Expired - Lifetime
- 1993-07-21 ES ES93917262T patent/ES2107049T3/es not_active Expired - Lifetime
- 1993-07-21 AT AT93917262T patent/ATE158279T1/de not_active IP Right Cessation
- 1993-08-03 ZA ZA935619A patent/ZA935619B/xx unknown
- 1993-08-03 TW TW082106192A patent/TW223017B/zh active
- 1993-08-07 MY MYPI93001565A patent/MY110826A/en unknown
- 1993-08-10 IL IL10664193A patent/IL106641A/en not_active IP Right Cessation
- 1993-08-12 MX MX9304882A patent/MX9304882A/es not_active IP Right Cessation
- 1993-08-13 CN CN93117781A patent/CN1039997C/zh not_active Expired - Fee Related
-
1995
- 1995-02-06 US US08/384,562 patent/US5567722A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 GR GR970403292T patent/GR3025640T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994004500A1 (en) | 1994-03-03 |
| TW223017B (enExample) | 1994-05-01 |
| MX9304882A (es) | 1994-07-29 |
| IL106641A0 (en) | 1993-12-08 |
| DK0655057T3 (da) | 1998-04-14 |
| AU4683193A (en) | 1994-03-15 |
| ZA935619B (en) | 1995-02-03 |
| MY110826A (en) | 1999-05-31 |
| DE69314041T2 (de) | 1998-02-05 |
| DE69314041D1 (de) | 1997-10-23 |
| CN1039997C (zh) | 1998-09-30 |
| EP0655057A1 (en) | 1995-05-31 |
| US5567722A (en) | 1996-10-22 |
| JPH08500111A (ja) | 1996-01-09 |
| WO1994004499A1 (en) | 1994-03-03 |
| AU4530693A (en) | 1994-03-15 |
| GR3025640T3 (en) | 1998-03-31 |
| CN1090575A (zh) | 1994-08-10 |
| ES2107049T3 (es) | 1997-11-16 |
| EP0655057B1 (en) | 1997-09-17 |
| ATE158279T1 (de) | 1997-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |