MX9304882A - Cianoguanidinas como bloqueadoras del canal k fundamento de la invencion. - Google Patents

Cianoguanidinas como bloqueadoras del canal k fundamento de la invencion.

Info

Publication number
MX9304882A
MX9304882A MX9304882A MX9304882A MX9304882A MX 9304882 A MX9304882 A MX 9304882A MX 9304882 A MX9304882 A MX 9304882A MX 9304882 A MX9304882 A MX 9304882A MX 9304882 A MX9304882 A MX 9304882A
Authority
MX
Mexico
Prior art keywords
alkyl
hydrogen
formula
compounds
cyanoguanidines
Prior art date
Application number
MX9304882A
Other languages
English (en)
Inventor
Jackson B Hester Jr
Stephen J Humphrey
Kaushik D Meisheri
James H Ludens
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9304882A publication Critical patent/MX9304882A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos cianoguanidina de la Fórmula I y sus sales por adición de ácido farmacéuticamente aceptables: en donde R1 es hidrógeno o metilo; C2-C6 alquilino, C3-C5 cicloalquilo, C3-C5 cicloalquenilhidroximetilo, metoxi-C1-C5 alquilo, o R3 y R4 se selecciona cada uno independientemente para que sean hidrógeno, C1-C4 alquilo, F, Cl, Br, I o CF3; R5 es hidrógeno, F o CL. R6 es hidrógeno,-NH2,-NHCH3,NHC2H5,-NHCH(CH3)2,-N(CH3)2, -N(C2H5)2,-NH(CH2)m-OC1-C3alquilo (en donde m es 2 ó 3), -NHC(O)C1-C3alquilo, Cl o Br, y n is 0 ó 1. Los compuestos de la Fórmula I son bloqueadores del canal potasio que son útiles para el tratamiento de trastornos tales como fallo cardíaco congestivo e hipertensión y como un diurético.
MX9304882A 1992-08-13 1993-08-12 Cianoguanidinas como bloqueadoras del canal k fundamento de la invencion. MX9304882A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92979592A 1992-08-13 1992-08-13

Publications (1)

Publication Number Publication Date
MX9304882A true MX9304882A (es) 1994-07-29

Family

ID=25458467

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304882A MX9304882A (es) 1992-08-13 1993-08-12 Cianoguanidinas como bloqueadoras del canal k fundamento de la invencion.

Country Status (16)

Country Link
US (1) US5567722A (es)
EP (1) EP0655057B1 (es)
JP (1) JPH08500111A (es)
CN (1) CN1039997C (es)
AT (1) ATE158279T1 (es)
AU (2) AU4530693A (es)
DE (1) DE69314041T2 (es)
DK (1) DK0655057T3 (es)
ES (1) ES2107049T3 (es)
GR (1) GR3025640T3 (es)
IL (1) IL106641A (es)
MX (1) MX9304882A (es)
MY (1) MY110826A (es)
TW (1) TW223017B (es)
WO (2) WO1994004499A1 (es)
ZA (1) ZA935619B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2179036A1 (en) * 1994-01-28 1995-08-03 Stephen J. Humphrey Cyanoguanidines as k-channel blockers
AUPN193095A0 (en) * 1995-03-24 1995-04-27 Polychip Pharmaceuticals Pty Ltd Potassium ion channel blockers
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
EP0939634A4 (en) * 1996-08-15 2001-02-21 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
EP1917244A2 (de) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
CN113683535B (zh) * 2020-05-18 2022-08-30 中国药科大学 含氰胍结构的化合物及其制备方法与用途
CN112042664B (zh) * 2020-09-18 2022-06-10 广州古神生物科技有限公司 防霉抗菌剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
NL8000869A (nl) * 1979-02-16 1980-08-19 Eisai Co Ltd Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan.
JPH01166119A (ja) * 1987-12-23 1989-06-30 Hitachi Ltd データ入力装置の制御方式
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
CA2009074C (en) * 1989-02-03 1999-07-27 David Wayne Robertson Improvements in and relating to guanidine derivatives
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers

Also Published As

Publication number Publication date
CN1090575A (zh) 1994-08-10
IL106641A (en) 2001-01-11
AU4530693A (en) 1994-03-15
JPH08500111A (ja) 1996-01-09
TW223017B (es) 1994-05-01
AU4683193A (en) 1994-03-15
ZA935619B (en) 1995-02-03
MY110826A (en) 1999-05-31
US5567722A (en) 1996-10-22
WO1994004499A1 (en) 1994-03-03
ATE158279T1 (de) 1997-10-15
EP0655057B1 (en) 1997-09-17
DE69314041T2 (de) 1998-02-05
EP0655057A1 (en) 1995-05-31
ES2107049T3 (es) 1997-11-16
IL106641A0 (en) 1993-12-08
CN1039997C (zh) 1998-09-30
DK0655057T3 (da) 1998-04-14
DE69314041D1 (de) 1997-10-23
GR3025640T3 (en) 1998-03-31
WO1994004500A1 (en) 1994-03-03

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees