AU4530693A - Cyanoguanidines as potassium channel blockers - Google Patents
Cyanoguanidines as potassium channel blockersInfo
- Publication number
- AU4530693A AU4530693A AU45306/93A AU4530693A AU4530693A AU 4530693 A AU4530693 A AU 4530693A AU 45306/93 A AU45306/93 A AU 45306/93A AU 4530693 A AU4530693 A AU 4530693A AU 4530693 A AU4530693 A AU 4530693A
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- hydrogen
- channel blockers
- potassium channel
- cyanoguanidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical class NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003450 potassium channel blocker Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92979592A | 1992-08-13 | 1992-08-13 | |
| US929795 | 1992-08-13 | ||
| PCT/US1993/005458 WO1994004499A1 (en) | 1992-08-13 | 1993-06-11 | Cyanoguanidines as potassium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4530693A true AU4530693A (en) | 1994-03-15 |
Family
ID=25458467
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU45306/93A Abandoned AU4530693A (en) | 1992-08-13 | 1993-06-11 | Cyanoguanidines as potassium channel blockers |
| AU46831/93A Abandoned AU4683193A (en) | 1992-08-13 | 1993-07-21 | Cyanoguanidines as potassium channel blockers |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU46831/93A Abandoned AU4683193A (en) | 1992-08-13 | 1993-07-21 | Cyanoguanidines as potassium channel blockers |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5567722A (enExample) |
| EP (1) | EP0655057B1 (enExample) |
| JP (1) | JPH08500111A (enExample) |
| CN (1) | CN1039997C (enExample) |
| AT (1) | ATE158279T1 (enExample) |
| AU (2) | AU4530693A (enExample) |
| DE (1) | DE69314041T2 (enExample) |
| DK (1) | DK0655057T3 (enExample) |
| ES (1) | ES2107049T3 (enExample) |
| GR (1) | GR3025640T3 (enExample) |
| IL (1) | IL106641A (enExample) |
| MX (1) | MX9304882A (enExample) |
| MY (1) | MY110826A (enExample) |
| TW (1) | TW223017B (enExample) |
| WO (2) | WO1994004499A1 (enExample) |
| ZA (1) | ZA935619B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2179036A1 (en) * | 1994-01-28 | 1995-08-03 | Stephen J. Humphrey | Cyanoguanidines as k-channel blockers |
| AUPN193095A0 (en) * | 1995-03-24 | 1995-04-27 | Polychip Pharmaceuticals Pty Ltd | Potassium ion channel blockers |
| AR008290A1 (es) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
| JP2000516620A (ja) * | 1996-08-15 | 2000-12-12 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
| GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
| CN113683535B (zh) * | 2020-05-18 | 2022-08-30 | 中国药科大学 | 含氰胍结构的化合物及其制备方法与用途 |
| CN112042664B (zh) * | 2020-09-18 | 2022-06-10 | 广州古神生物科技有限公司 | 防霉抗菌剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
| JPH01166119A (ja) * | 1987-12-23 | 1989-06-30 | Hitachi Ltd | データ入力装置の制御方式 |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| PT93033B (pt) * | 1989-02-03 | 1996-03-29 | Lilly Co Eli | Processo para a preparacao de derivados de guanidina |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
-
1993
- 1993-06-11 WO PCT/US1993/005458 patent/WO1994004499A1/en not_active Ceased
- 1993-06-11 AU AU45306/93A patent/AU4530693A/en not_active Abandoned
- 1993-07-21 DK DK93917262.3T patent/DK0655057T3/da active
- 1993-07-21 AU AU46831/93A patent/AU4683193A/en not_active Abandoned
- 1993-07-21 JP JP6506258A patent/JPH08500111A/ja active Pending
- 1993-07-21 DE DE69314041T patent/DE69314041T2/de not_active Expired - Fee Related
- 1993-07-21 WO PCT/US1993/006752 patent/WO1994004500A1/en not_active Ceased
- 1993-07-21 EP EP93917262A patent/EP0655057B1/en not_active Expired - Lifetime
- 1993-07-21 ES ES93917262T patent/ES2107049T3/es not_active Expired - Lifetime
- 1993-07-21 AT AT93917262T patent/ATE158279T1/de not_active IP Right Cessation
- 1993-08-03 ZA ZA935619A patent/ZA935619B/xx unknown
- 1993-08-03 TW TW082106192A patent/TW223017B/zh active
- 1993-08-07 MY MYPI93001565A patent/MY110826A/en unknown
- 1993-08-10 IL IL10664193A patent/IL106641A/en not_active IP Right Cessation
- 1993-08-12 MX MX9304882A patent/MX9304882A/es not_active IP Right Cessation
- 1993-08-13 CN CN93117781A patent/CN1039997C/zh not_active Expired - Fee Related
-
1995
- 1995-02-06 US US08/384,562 patent/US5567722A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 GR GR970403292T patent/GR3025640T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL106641A (en) | 2001-01-11 |
| WO1994004500A1 (en) | 1994-03-03 |
| TW223017B (enExample) | 1994-05-01 |
| MX9304882A (es) | 1994-07-29 |
| IL106641A0 (en) | 1993-12-08 |
| DK0655057T3 (da) | 1998-04-14 |
| AU4683193A (en) | 1994-03-15 |
| ZA935619B (en) | 1995-02-03 |
| MY110826A (en) | 1999-05-31 |
| DE69314041T2 (de) | 1998-02-05 |
| DE69314041D1 (de) | 1997-10-23 |
| CN1039997C (zh) | 1998-09-30 |
| EP0655057A1 (en) | 1995-05-31 |
| US5567722A (en) | 1996-10-22 |
| JPH08500111A (ja) | 1996-01-09 |
| WO1994004499A1 (en) | 1994-03-03 |
| GR3025640T3 (en) | 1998-03-31 |
| CN1090575A (zh) | 1994-08-10 |
| ES2107049T3 (es) | 1997-11-16 |
| EP0655057B1 (en) | 1997-09-17 |
| ATE158279T1 (de) | 1997-10-15 |
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