ES8600258A1 - Procedimiento de preparar derivados triazolicos - Google Patents
Procedimiento de preparar derivados triazolicosInfo
- Publication number
- ES8600258A1 ES8600258A1 ES535998A ES535998A ES8600258A1 ES 8600258 A1 ES8600258 A1 ES 8600258A1 ES 535998 A ES535998 A ES 535998A ES 535998 A ES535998 A ES 535998A ES 8600258 A1 ES8600258 A1 ES 8600258A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- image
- dihydroaryloxyalkylamino
- reacting
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 abstract 1
- 102000000543 Histamine Receptors Human genes 0.000 abstract 1
- 108010002059 Histamine Receptors Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- CKQOECSSEWMCOD-UHFFFAOYSA-N cyanoiminocarbamodithioic acid Chemical compound SC(=S)N=NC#N CKQOECSSEWMCOD-UHFFFAOYSA-N 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 150000002429 hydrazines Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS TRIAZOLICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES Y R3 REPRESENTA ALQUILO C1C4 O HIDROXIALQUILO C2C4.COMPRENDE LA REACCION DE REDUCCION DE UNA ARILOXIALQUILAMINA, DE FORMULA (II) EN LA QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I) CON EXCESO DE SODIO METALICO EN AMONIACO LIQUIDO A UNA TEMPERATURA ENTRE C85JC Y C33JC; SEGUIDA DEL TRATAMIENTO CON DIMETILESTER DE ACIDO N-CIANOIMINODITICOCARBAMICO EN ISOPROPANOL; Y FINALMENTE, REACCION DE LA ISOTIOCARBAMIDA OBTENIDA CON UNA HIDRACINA SUSTITUIDA DE FORMULA R3-NH-NH2, EN LA QUE R3 ES EL MISMO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ULCERACION GASTRICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU833145A HU191095B (en) | 1983-09-09 | 1983-09-09 | Process for the production of 3,5 diamino-1,2,4-triazole-derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES535998A0 ES535998A0 (es) | 1985-10-16 |
| ES8600258A1 true ES8600258A1 (es) | 1985-10-16 |
Family
ID=10962781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535998A Expired ES8600258A1 (es) | 1983-09-09 | 1984-09-07 | Procedimiento de preparar derivados triazolicos |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS60100543A (es) |
| AT (1) | AT389109B (es) |
| CS (1) | CS244830B2 (es) |
| DD (1) | DD219767A5 (es) |
| DE (1) | DE3433143A1 (es) |
| ES (1) | ES8600258A1 (es) |
| FI (1) | FI80685C (es) |
| FR (1) | FR2551752B1 (es) |
| GB (1) | GB2146331B (es) |
| HU (1) | HU191095B (es) |
| IT (1) | IT1180224B (es) |
| SU (1) | SU1480767A3 (es) |
| YU (1) | YU45654B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19848649C5 (de) | 1998-10-22 | 2008-11-27 | Peter Greiner | Kohlenstoffkolben für eine Brennkraftmaschine |
| US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU538818B2 (en) * | 1979-10-22 | 1984-08-30 | Glaxo Group Limited | 1-h-1,2,4-triazole compounds |
| DK558181A (da) * | 1981-01-30 | 1982-07-31 | Smithkline Corp | Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler |
-
1983
- 1983-09-09 HU HU833145A patent/HU191095B/hu not_active IP Right Cessation
-
1984
- 1984-09-07 FI FI843527A patent/FI80685C/fi not_active IP Right Cessation
- 1984-09-07 YU YU154784A patent/YU45654B/sh unknown
- 1984-09-07 DD DD84267111A patent/DD219767A5/de not_active IP Right Cessation
- 1984-09-07 CS CS846774A patent/CS244830B2/cs unknown
- 1984-09-07 ES ES535998A patent/ES8600258A1/es not_active Expired
- 1984-09-07 FR FR8413763A patent/FR2551752B1/fr not_active Expired
- 1984-09-07 GB GB08422620A patent/GB2146331B/en not_active Expired
- 1984-09-07 IT IT22568/84A patent/IT1180224B/it active
- 1984-09-07 AT AT0287084A patent/AT389109B/de not_active IP Right Cessation
- 1984-09-07 SU SU843787351A patent/SU1480767A3/ru active
- 1984-09-07 JP JP59186612A patent/JPS60100543A/ja active Pending
- 1984-09-10 DE DE19843433143 patent/DE3433143A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| YU154784A (en) | 1986-12-31 |
| ES535998A0 (es) | 1985-10-16 |
| FR2551752B1 (fr) | 1987-04-24 |
| AT389109B (de) | 1989-10-25 |
| DE3433143A1 (de) | 1985-03-28 |
| ATA287084A (de) | 1989-03-15 |
| IT1180224B (it) | 1987-09-23 |
| GB8422620D0 (en) | 1984-10-10 |
| JPS60100543A (ja) | 1985-06-04 |
| FI80685C (fi) | 1990-07-10 |
| IT8422568A0 (it) | 1984-09-07 |
| DD219767A5 (de) | 1985-03-13 |
| FR2551752A1 (fr) | 1985-03-15 |
| FI843527L (fi) | 1985-03-10 |
| CS244830B2 (en) | 1986-08-14 |
| FI80685B (fi) | 1990-03-30 |
| GB2146331B (en) | 1987-05-13 |
| HUT34963A (en) | 1985-05-28 |
| HU191095B (en) | 1987-01-28 |
| GB2146331A (en) | 1985-04-17 |
| YU45654B (sh) | 1992-07-20 |
| SU1480767A3 (ru) | 1989-05-15 |
| FI843527A0 (fi) | 1984-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |