IL105494A - Process for preparing cephalosporins - Google Patents

Process for preparing cephalosporins

Info

Publication number
IL105494A
IL105494A IL10549493A IL10549493A IL105494A IL 105494 A IL105494 A IL 105494A IL 10549493 A IL10549493 A IL 10549493A IL 10549493 A IL10549493 A IL 10549493A IL 105494 A IL105494 A IL 105494A
Authority
IL
Israel
Prior art keywords
amino
cephalosporanic
alpha
derivatives
acid
Prior art date
Application number
IL10549493A
Other languages
English (en)
Other versions
IL105494A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL105494A0 publication Critical patent/IL105494A0/xx
Publication of IL105494A publication Critical patent/IL105494A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
IL10549493A 1992-04-24 1993-04-22 Process for preparing cephalosporins IL105494A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87425792A 1992-04-24 1992-04-24

Publications (2)

Publication Number Publication Date
IL105494A0 IL105494A0 (en) 1993-08-18
IL105494A true IL105494A (en) 2000-08-13

Family

ID=25363336

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10549493A IL105494A (en) 1992-04-24 1993-04-22 Process for preparing cephalosporins

Country Status (22)

Country Link
US (1) US5801011A (fr)
EP (1) EP0567323B1 (fr)
JP (1) JPH069649A (fr)
KR (1) KR930021643A (fr)
CN (1) CN1063491C (fr)
AT (1) ATE183778T1 (fr)
AU (1) AU664078B2 (fr)
BR (1) BR9301627A (fr)
CA (1) CA2094686A1 (fr)
CZ (1) CZ69593A3 (fr)
DE (1) DE69326095T2 (fr)
DK (1) DK0567323T3 (fr)
ES (1) ES2135446T3 (fr)
FI (1) FI931815A (fr)
GR (1) GR3031739T3 (fr)
HU (1) HUT64352A (fr)
IL (1) IL105494A (fr)
MX (1) MX9302354A (fr)
NO (1) NO931483L (fr)
NZ (1) NZ247464A (fr)
YU (1) YU27893A (fr)
ZA (1) ZA932809B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8799498A (en) * 1997-06-10 1998-12-30 Gist-Brocades B.V. Process for enzymatically preparing a beta-lactam antibiotic and this antibiotic
CZ300467B6 (cs) 2007-01-31 2009-05-27 Mikrobiologický ústav AV CR, v.v.i. Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN103805671B (zh) * 2013-11-11 2015-08-26 华北制药河北华民药业有限责任公司 一种制备头孢氨苄的方法
CN105002253B (zh) * 2015-07-09 2019-02-15 山东罗欣药业集团恒欣药业有限公司 一种新型头孢类抗感染药物的酶促合成工艺
US20170101660A1 (en) 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5548797B1 (fr) * 1971-04-02 1980-12-08
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
IT1045797B (it) * 1973-12-20 1980-06-10 Snam Progetti Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile
US4113566A (en) * 1976-11-26 1978-09-12 Pfizer Inc. Process for preparing 6-aminopenicillanic acid
CH640240A5 (en) * 1979-02-09 1983-12-30 I B S A Inst Biochimique Sa Preparation of penicillins and cephalosporins from precursors obtained by hydrolysis of natural penicillins/cephalosporins, using enzymatic complexes immobilised on solid carriers
JPH0791291B2 (ja) * 1985-12-30 1995-10-04 イ−ライ・リリ−・アンド・カンパニ− １−カルバセフアロスポリン抗生物質
DE69133509T2 (de) * 1990-07-04 2006-08-24 Dsm Ip Assets B.V. Verfahren zur herstellung von beta-lactamen
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
EP0618979A1 (fr) * 1991-12-19 1994-10-12 Gist-Brocades B.V. PROCEDE AMELIORE POUR LA PREPARATION DE CERTAINES $g(b)-LACTAMINES
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase

Also Published As

Publication number Publication date
DE69326095T2 (de) 2000-01-20
FI931815A0 (fi) 1993-04-22
HU9301188D0 (en) 1993-07-28
MX9302354A (es) 1994-05-31
FI931815A (fi) 1993-10-25
EP0567323A3 (fr) 1994-04-27
CN1077749A (zh) 1993-10-27
DE69326095D1 (de) 1999-09-30
IL105494A0 (en) 1993-08-18
CZ69593A3 (en) 1993-12-15
EP0567323B1 (fr) 1999-08-25
YU27893A (sh) 1996-07-24
US5801011A (en) 1998-09-01
JPH069649A (ja) 1994-01-18
DK0567323T3 (da) 1999-12-13
NO931483D0 (no) 1993-04-22
AU664078B2 (en) 1995-11-02
GR3031739T3 (en) 2000-02-29
ES2135446T3 (es) 1999-11-01
CN1063491C (zh) 2001-03-21
CA2094686A1 (fr) 1993-10-25
AU3712593A (en) 1993-10-28
NO931483L (no) 1993-10-25
BR9301627A (pt) 1993-10-26
EP0567323A2 (fr) 1993-10-27
KR930021643A (ko) 1993-11-22
NZ247464A (en) 1994-12-22
HUT64352A (en) 1993-12-28
ATE183778T1 (de) 1999-09-15
ZA932809B (en) 1994-10-21

Similar Documents

Publication Publication Date Title
US20030073156A1 (en) Process for preparing cephalosporin derivatives
IL105494A (en) Process for preparing cephalosporins
EP0582102B1 (fr) Méthode pour l'acylation de groupe 7-amino du noyau de céphalosporine
KR100667143B1 (ko) 가용성 측쇄 에스테르와 효소 아실라제를 사용하는 β-락탐 항균 물질의 합성법
DE3563858D1 (en) Process for the preparation of l-alpha-aminoacids
HUT45006A (en) Process for producing 4-halogeno-2-/oxy-imino/-3-oxo-butiric acid derivatives
EP1416054B1 (fr) Procédé enzymatique simple pour préparer du cefazolin
IE921073A1 (en) Enzymatic process for the production of cefonicid
IL81555A0 (en) Enzymatic process for 3-substituted cephalosporins
RU93004674A (ru) Способ получения цефалоспоринов
AU3300893A (en) Diacetyl production
Baldaro Effect of temperature on enzymatic synthesis of cephalosporins
ES2002912A6 (es) Procedimiento para la produccion de antibioticos de cefalosporina
TH13553A (th) กรรมวิธีที่ดีขึ้นสำหรับเตรียมเซฟาโลสพอรินส์
JPS5238092A (en) Method of preparing 7-amino cephalosporanic acids

Legal Events

Date Code Title Description
FF Patent granted
RH1 Patent not in force