IL105219A0 - Cyclohexane-ylidene compounds and pharmaceutical compositions containing them - Google Patents
Cyclohexane-ylidene compounds and pharmaceutical compositions containing themInfo
- Publication number
- IL105219A0 IL105219A0 IL105219A IL10521993A IL105219A0 IL 105219 A0 IL105219 A0 IL 105219A0 IL 105219 A IL105219 A IL 105219A IL 10521993 A IL10521993 A IL 10521993A IL 105219 A0 IL105219 A0 IL 105219A0
- Authority
- IL
- Israel
- Prior art keywords
- cyclohexane
- pharmaceutical compositions
- compositions containing
- ylidene compounds
- compounds
- Prior art date
Links
- -1 Cyclohexane-ylidene compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001934 cyclohexanes Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000006433 tumor necrosis factor production Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86208392A | 1992-04-02 | 1992-04-02 | |
US96875392A | 1992-10-30 | 1992-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL105219A0 true IL105219A0 (en) | 1993-07-08 |
Family
ID=27127666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL105219A IL105219A0 (en) | 1992-04-02 | 1993-03-30 | Cyclohexane-ylidene compounds and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (3) | US5449686A (de) |
EP (2) | EP0633775B1 (de) |
JP (1) | JP3195353B2 (de) |
CN (2) | CN1092407A (de) |
AT (1) | ATE203159T1 (de) |
AU (2) | AU3738393A (de) |
CA (1) | CA2133337C (de) |
CY (1) | CY2311B1 (de) |
DE (2) | DE69328778T2 (de) |
DK (1) | DK0636025T3 (de) |
ES (1) | ES2158860T3 (de) |
GR (1) | GR3036853T3 (de) |
HK (1) | HK1012262A1 (de) |
IL (1) | IL105219A0 (de) |
MA (2) | MA22858A1 (de) |
MX (1) | MX9301904A (de) |
NZ (1) | NZ251176A (de) |
PT (1) | PT636025E (de) |
SA (1) | SA93140227B1 (de) |
SI (1) | SI9300171A (de) |
WO (1) | WO1993019748A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU677776B2 (en) * | 1992-04-02 | 1997-05-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
GB9226830D0 (en) * | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
US5622977A (en) * | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
US6323041B1 (en) * | 1993-06-11 | 2001-11-27 | Pfizer Inc. | Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
WO1995009624A1 (en) * | 1993-10-01 | 1995-04-13 | Smithkline Beecham Corporation | Compounds, compositions and treatment of allergies and inflammation |
GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
ATE260911T1 (de) * | 1993-12-22 | 2004-03-15 | Celltech R&D Ltd | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412573D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
JPH10511391A (ja) * | 1994-12-23 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | 3,3−(二置換)シクロヘキサン−1−オール二量体および関連化合物 |
JPH10512552A (ja) * | 1994-12-23 | 1998-12-02 | スミスクライン・ビーチャム・コーポレイション | 4,4−(二置換)シクロヘキサン−1−オン二量体および関連化合物 |
WO1996019992A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ylidine acetate monomers and related compounds |
JPH10511665A (ja) * | 1994-12-23 | 1998-11-10 | スミスクライン・ビーチャム・コーポレイション | 3,3−(二置換)シクロヘキサン−1−イリジンアセテート二量体および関連化合物 |
EP0799036A4 (de) * | 1994-12-23 | 1998-03-25 | Smithkline Beecham Corp | 4,4-(disubstituierte)cyclohexan-1-ylidinacetat dimere und verwandte verbindungen |
EP0799205B1 (de) * | 1994-12-23 | 1999-09-08 | Smithkline Beecham Corporation | 1,4,4-(trisubstituierte)cyclohex-1-en-derivate als pde iv- und tnf-hemmer |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
US5900417A (en) * | 1995-12-21 | 1999-05-04 | Smithkline Beecham Corporation | 1,3,3-(Trisubstituted)cyclohexanemonomers and related compounds |
US5767151A (en) * | 1995-12-21 | 1998-06-16 | Smithkline Beecham Corporation | 3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds |
GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
WO1997048697A1 (en) | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
JP2001507349A (ja) | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式2−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
CZ2002460A3 (cs) * | 1999-08-10 | 2002-06-12 | Smithkline Beecham Corporation | 1,4-Substituované 4,4-diarylcyklohexany |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
JP4291135B2 (ja) | 2001-05-29 | 2009-07-08 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Cdk阻害性ピリミジン、それらの製造および薬剤としての使用 |
US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
US20090274676A1 (en) * | 2003-07-31 | 2009-11-05 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050085430A1 (en) * | 2003-07-31 | 2005-04-21 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US8013187B2 (en) * | 2004-12-02 | 2011-09-06 | Amorepacific Corporation | 2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-α |
US7888351B2 (en) * | 2006-04-11 | 2011-02-15 | Novartis Ag | Organic compounds |
JP2010513357A (ja) * | 2006-12-22 | 2010-04-30 | ノバルティス アーゲー | Dpp−iv阻害剤としての1−アミノメチル−1−フェニル−シクロヘキサン誘導体 |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
CA2682730A1 (en) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
US7943658B2 (en) * | 2007-07-23 | 2011-05-17 | Bristol-Myers Squibb Company | Indole indane amide compounds useful as CB2 agonists and method |
EP2196465A1 (de) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea-Derivate als PDE4 Hemmern |
EP2226323A1 (de) | 2009-02-27 | 2010-09-08 | Almirall, S.A. | Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate |
BR112012007091A2 (pt) * | 2009-10-01 | 2016-04-19 | Alcon Res Ltd | composições de olopatadina e seus usos |
EP2380890A1 (de) | 2010-04-23 | 2011-10-26 | Almirall, S.A. | Neue 7,8-Dihydro-1,6-Naphthyridin-5(6H)-on-Derivate als PDE4 Inhibitoren |
EP2394998A1 (de) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl Derivate als PDE4 Inhibitoren |
CN102336704B (zh) * | 2011-10-19 | 2013-04-17 | 丁克 | 一种制备罗氟司特的方法 |
EP2776395A2 (de) | 2011-11-09 | 2014-09-17 | Mylan Laboratories, Limited | Verfahren zur herstellung von roflumilast |
GB201515921D0 (en) * | 2015-09-08 | 2015-10-21 | Parker Hannifin Mfg Uk Ltd | Method |
JP7104989B2 (ja) | 2016-11-18 | 2022-07-22 | ゴールデン バイオテクノロジー コーポレーション | アトピー性皮膚炎を処置するための方法および組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795A (en) * | 1846-10-07 | Carriage-step | ||
DE1793383C3 (de) * | 1968-09-10 | 1979-03-01 | Knoll Ag, 6700 Ludwigshafen | 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
US3979444A (en) * | 1974-05-28 | 1976-09-07 | The Upjohn Company | 4-Arylcyclohexylamines |
US4115589A (en) * | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
-
1993
- 1993-03-05 JP JP51744593A patent/JP3195353B2/ja not_active Expired - Fee Related
- 1993-03-05 WO PCT/US1993/001990 patent/WO1993019748A1/en active IP Right Grant
- 1993-03-05 AU AU37383/93A patent/AU3738393A/en not_active Abandoned
- 1993-03-05 EP EP93906297A patent/EP0633775B1/de not_active Expired - Lifetime
- 1993-03-05 DE DE69328778T patent/DE69328778T2/de not_active Expired - Fee Related
- 1993-03-12 PT PT93907493T patent/PT636025E/pt unknown
- 1993-03-12 NZ NZ251176A patent/NZ251176A/en not_active IP Right Cessation
- 1993-03-12 DK DK93907493T patent/DK0636025T3/da active
- 1993-03-12 EP EP93907493A patent/EP0636025B1/de not_active Expired - Lifetime
- 1993-03-12 DE DE69330459T patent/DE69330459T2/de not_active Expired - Lifetime
- 1993-03-12 AT AT93907493T patent/ATE203159T1/de active
- 1993-03-12 CA CA002133337A patent/CA2133337C/en not_active Expired - Lifetime
- 1993-03-12 ES ES93907493T patent/ES2158860T3/es not_active Expired - Lifetime
- 1993-03-30 IL IL105219A patent/IL105219A0/xx unknown
- 1993-04-01 MA MA23147A patent/MA22858A1/fr unknown
- 1993-04-01 MA MA23146A patent/MA22857A1/fr unknown
- 1993-04-01 MX MX9301904A patent/MX9301904A/es unknown
- 1993-04-02 CN CN93105726A patent/CN1092407A/zh active Pending
- 1993-04-02 SI SI9300171A patent/SI9300171A/sl unknown
- 1993-04-02 CN CNB931057000A patent/CN1146536C/zh not_active Expired - Lifetime
- 1993-09-29 SA SA93140227A patent/SA93140227B1/ar unknown
-
1994
- 1994-09-29 US US08/313,095 patent/US5449686A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/488,556 patent/US5811455A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,633 patent/US5631286A/en not_active Expired - Lifetime
-
1996
- 1996-11-26 AU AU71999/96A patent/AU708544B2/en not_active Expired
-
1998
- 1998-12-15 HK HK98113532A patent/HK1012262A1/xx not_active IP Right Cessation
-
2001
- 2001-10-09 GR GR20010401717T patent/GR3036853T3/el unknown
-
2003
- 2003-01-15 CY CY0300003A patent/CY2311B1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL105219A0 (en) | Cyclohexane-ylidene compounds and pharmaceutical compositions containing them | |
CA2133439A1 (en) | Compounds useful for treating allergic and inflammatory diseases | |
WO1993019720A3 (en) | Compounds | |
MX9301942A (es) | Derivados de ciclohexan-ilideno novedosos. | |
DE69628019D1 (de) | Chinolone und deren therapeutische verwendung | |
ZA948353B (en) | Novel (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans | |
GB9204808D0 (en) | Novel compositions of matter | |
PL340551A1 (en) | Derivatives of hydroxamic and carboxylic acids exhibiting mmp & tnf inhibitive action | |
ZA948669B (en) | New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions | |
PH25313A (en) | Carboxylic acid derivatives, pharmaceutical compositions containing them | |
AU4617093A (en) | Substituted cyclohexane derivatives for the treatment of diseases | |
GB9116056D0 (en) | Compounds | |
KR100344711B1 (de) | ||
FR2658190B1 (fr) | Esters d'aminoacides de l'hydroquinone, leur procede de preparation et compositions pharmaceutiques ou cosmetiques les contenant. | |
DE69321096D1 (de) | Katecholamine-diphosphate und diese enthaltende arzneimittel | |
MX9708385A (es) | Derivados novedosos de tetraciclina, composiciones que los contienen, y el uso de las mismas. | |
GR920100519A (el) | Ενώσεις. |