IL104122A - Aromatic esters of phenylenedialkanoates, process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of human neutrophil elastase - Google Patents
Aromatic esters of phenylenedialkanoates, process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of human neutrophil elastaseInfo
- Publication number
- IL104122A IL104122A IL104122A IL10412292A IL104122A IL 104122 A IL104122 A IL 104122A IL 104122 A IL104122 A IL 104122A IL 10412292 A IL10412292 A IL 10412292A IL 104122 A IL104122 A IL 104122A
- Authority
- IL
- Israel
- Prior art keywords
- group
- compound according
- carbons
- compounds
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/809,378 US5216022A (en) | 1991-12-19 | 1991-12-19 | Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104122A0 IL104122A0 (en) | 1993-05-13 |
| IL104122A true IL104122A (en) | 1998-03-10 |
Family
ID=25201206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL104122A IL104122A (en) | 1991-12-19 | 1992-12-17 | Aromatic esters of phenylenedialkanoates, process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of human neutrophil elastase |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5216022A (de) |
| EP (1) | EP0618899B1 (de) |
| JP (1) | JP3127436B2 (de) |
| KR (1) | KR100250099B1 (de) |
| AT (1) | ATE135344T1 (de) |
| AU (1) | AU662379B2 (de) |
| CA (1) | CA2126195C (de) |
| DE (1) | DE69209092T2 (de) |
| DK (1) | DK0618899T3 (de) |
| ES (1) | ES2087568T3 (de) |
| FI (1) | FI942928A (de) |
| GR (1) | GR3019438T3 (de) |
| HU (1) | HUT71518A (de) |
| IL (1) | IL104122A (de) |
| MX (1) | MX9207428A (de) |
| NO (1) | NO302518B1 (de) |
| NZ (1) | NZ246115A (de) |
| TW (1) | TW211562B (de) |
| WO (1) | WO1993011760A1 (de) |
| ZA (1) | ZA929697B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795890A (en) * | 1995-09-27 | 1998-08-18 | Ono Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
| KR20000022532A (ko) * | 1996-06-27 | 2000-04-25 | 오노 야꾸힝 고교 가부시키가이샤 | 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물 |
| US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| PL2520654T3 (pl) | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| JP6216921B2 (ja) | 2011-06-24 | 2017-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１抗トリプシン融合分子のための組成物、方法および使用 |
| US10478508B2 (en) | 2012-01-10 | 2019-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| IL297211A (en) | 2020-04-16 | 2022-12-01 | Mereo Biopharma 4 Ltd | Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency |
| CA3234399A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683241A (en) * | 1984-05-21 | 1987-07-28 | G. D. Searle & Co. | Phenolic ester derivatives as elastase inhibitors |
| US5214191A (en) * | 1990-05-22 | 1993-05-25 | Cortech, Inc. | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase |
-
1991
- 1991-12-19 US US07/809,378 patent/US5216022A/en not_active Expired - Lifetime
-
1992
- 1992-12-01 JP JP05510954A patent/JP3127436B2/ja not_active Expired - Fee Related
- 1992-12-01 NZ NZ246115A patent/NZ246115A/en unknown
- 1992-12-01 EP EP92925470A patent/EP0618899B1/de not_active Expired - Lifetime
- 1992-12-01 CA CA002126195A patent/CA2126195C/en not_active Expired - Fee Related
- 1992-12-01 WO PCT/US1992/010358 patent/WO1993011760A1/en active IP Right Grant
- 1992-12-01 ES ES92925470T patent/ES2087568T3/es not_active Expired - Lifetime
- 1992-12-01 AT AT92925470T patent/ATE135344T1/de not_active IP Right Cessation
- 1992-12-01 HU HU9401842A patent/HUT71518A/hu unknown
- 1992-12-01 AU AU31510/93A patent/AU662379B2/en not_active Ceased
- 1992-12-01 KR KR1019940702129A patent/KR100250099B1/ko not_active IP Right Cessation
- 1992-12-01 DK DK92925470.4T patent/DK0618899T3/da active
- 1992-12-01 DE DE69209092T patent/DE69209092T2/de not_active Expired - Fee Related
- 1992-12-14 ZA ZA929697A patent/ZA929697B/xx unknown
- 1992-12-15 TW TW081110045A patent/TW211562B/zh active
- 1992-12-17 IL IL104122A patent/IL104122A/en not_active IP Right Cessation
- 1992-12-18 MX MX9207428A patent/MX9207428A/es not_active IP Right Cessation
-
1994
- 1994-06-17 NO NO942308A patent/NO302518B1/no not_active IP Right Cessation
- 1994-06-17 FI FI942928A patent/FI942928A/fi unknown
-
1996
- 1996-03-27 GR GR960400824T patent/GR3019438T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69209092D1 (de) | 1996-04-18 |
| EP0618899A4 (de) | 1994-11-02 |
| EP0618899B1 (de) | 1996-03-13 |
| HUT71518A (en) | 1995-12-28 |
| HU9401842D0 (en) | 1994-09-28 |
| KR100250099B1 (ko) | 2000-04-01 |
| JPH07502505A (ja) | 1995-03-16 |
| JP3127436B2 (ja) | 2001-01-22 |
| FI942928A0 (fi) | 1994-06-17 |
| NO942308D0 (no) | 1994-06-17 |
| CA2126195C (en) | 2004-11-09 |
| ES2087568T3 (es) | 1996-07-16 |
| TW211562B (de) | 1993-08-21 |
| DE69209092T2 (de) | 1996-07-25 |
| AU662379B2 (en) | 1995-08-31 |
| WO1993011760A1 (en) | 1993-06-24 |
| EP0618899A1 (de) | 1994-10-12 |
| MX9207428A (es) | 1993-06-01 |
| NO302518B1 (no) | 1998-03-16 |
| US5216022A (en) | 1993-06-01 |
| NZ246115A (en) | 1996-02-27 |
| AU3151093A (en) | 1993-07-19 |
| NO942308L (no) | 1994-06-17 |
| DK0618899T3 (da) | 1996-04-01 |
| ATE135344T1 (de) | 1996-03-15 |
| CA2126195A1 (en) | 1993-06-24 |
| GR3019438T3 (en) | 1996-06-30 |
| IL104122A0 (en) | 1993-05-13 |
| ZA929697B (en) | 1993-06-22 |
| FI942928A (fi) | 1994-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |