IL103283A - History of acid 2 carboxyalkyl - 2 indan - carboxamide-oxo-tricyclic benzazepine carboxylic acid, used as inhibitors of encephalins and ECA - Google Patents

History of acid 2 carboxyalkyl - 2 indan - carboxamide-oxo-tricyclic benzazepine carboxylic acid, used as inhibitors of encephalins and ECA

Info

Publication number
IL103283A
IL103283A IL10328392A IL10328392A IL103283A IL 103283 A IL103283 A IL 103283A IL 10328392 A IL10328392 A IL 10328392A IL 10328392 A IL10328392 A IL 10328392A IL 103283 A IL103283 A IL 103283A
Authority
IL
Israel
Prior art keywords
compound
alkyl
group
hydrogen
formula
Prior art date
Application number
IL10328392A
Other languages
English (en)
Hebrew (he)
Other versions
IL103283A0 (en
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Publication of IL103283A0 publication Critical patent/IL103283A0/xx
Publication of IL103283A publication Critical patent/IL103283A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL10328392A 1991-09-27 1992-09-24 History of acid 2 carboxyalkyl - 2 indan - carboxamide-oxo-tricyclic benzazepine carboxylic acid, used as inhibitors of encephalins and ECA IL103283A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76728991A 1991-09-27 1991-09-27
US92948292A 1992-08-20 1992-08-20

Publications (2)

Publication Number Publication Date
IL103283A0 IL103283A0 (en) 1993-02-21
IL103283A true IL103283A (en) 1999-04-11

Family

ID=27117892

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10328392A IL103283A (en) 1991-09-27 1992-09-24 History of acid 2 carboxyalkyl - 2 indan - carboxamide-oxo-tricyclic benzazepine carboxylic acid, used as inhibitors of encephalins and ECA

Country Status (15)

Country Link
EP (1) EP0534396B1 (fr)
JP (1) JP3173674B2 (fr)
KR (1) KR100271242B1 (fr)
AT (1) ATE143972T1 (fr)
AU (1) AU657793B2 (fr)
CA (1) CA2079143C (fr)
DE (1) DE69214397T2 (fr)
DK (1) DK0534396T3 (fr)
ES (1) ES2095380T3 (fr)
FI (1) FI101302B1 (fr)
GR (1) GR3021420T3 (fr)
HU (1) HU214821B (fr)
IL (1) IL103283A (fr)
NO (1) NO300846B1 (fr)
NZ (1) NZ244462A (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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ES2106112T3 (es) * 1991-09-27 1997-11-01 Merrell Pharma Inc Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace.
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
HUT71246A (en) * 1992-08-24 1995-11-28 Merrell Pharma Inc Mercaptoacylamine-substituted benzazepine derivatives condensed with heterocycles and process for preparing them
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
EP0706525A1 (fr) * 1993-06-30 1996-04-17 Novartis AG Derives d'azepine tricycliques antihypertension utilises comme inhibiteurs d'encephalinase et d'ace
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
EP0746566A1 (fr) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
ATE266040T1 (de) * 1994-12-21 2004-05-15 Aventis Pharma Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
ES2246575T3 (es) 1998-06-17 2006-02-16 Bristol-Myers Squibb Company Prevencion del infarto cerebral mediante la administracion de una combinacion de un farmaco antiplaquetario bloqueador del receptor adp y un farmaco antihipertensivo.
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EE05670B1 (et) 1999-08-30 2013-08-15 Aventis Pharma Deutschland Gmbh Ramipriil kardiovaskulaarsete haigusjuhtude „rahoidmiseks
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
AU2002348276A1 (en) 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
EP2089389A2 (fr) 2006-11-01 2009-08-19 Bristol-Myers Squibb Company Modulateur du récepteur de glucocorticoïdes, ap-1, et/ou activité de nf-kb et leur utilisation
EP2089355A2 (fr) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulateurs de recepteur de glucocorticoide, d'activite ap-1 et/ou nf- kappa b, et leur utilisation
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP2065373A1 (fr) 2007-11-30 2009-06-03 Bayer CropScience AG Dérivés de chirale 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole et dérivés de 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl) sulfinyl]-4,5-dihydroisoxazole, leur procédé de fabrication ainsi que leur utilisation en tant qu'herbicides et régulateurs de croissance des plantes
EP2065374A1 (fr) 2007-11-30 2009-06-03 Bayer CropScience AG Dérivés de 2-(benzyl- et 1H-pyrazol-4-ylmethyl)sulfinyl-thiazole en tant qu'herbicides et régulateurs de la croissance de plantes
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2009158380A1 (fr) 2008-06-24 2009-12-30 Bristol-Myers Squibb Company Modulateurs de cyclopentathiopène du récepteur glucocorticoïde, ap-1, et/ou activité nf-kappa b et utilisation de ceux-ci
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015027021A1 (fr) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Dérivés imide et acylurée utilisés comme modulateurs du récepteur de glucocorticoïdes

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Publication number Priority date Publication date Assignee Title
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
CA1337654C (fr) * 1986-06-13 1995-11-28 Gary A. Flynn Lactames tricycliques fondus servant d'agents antihypertenseurs
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
CA2053340C (fr) * 1990-10-18 2002-04-02 Timothy P. Burkholder Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace
NZ241023A (en) * 1990-12-21 1994-10-26 Merrell Dow Pharma Condensed benzazepine derivatives and pharmaceutical compositions
ES2106112T3 (es) * 1991-09-27 1997-11-01 Merrell Pharma Inc Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace.

Also Published As

Publication number Publication date
CA2079143A1 (fr) 1993-03-28
ATE143972T1 (de) 1996-10-15
AU2524692A (en) 1993-04-01
NO300846B1 (no) 1997-08-04
DE69214397T2 (de) 1997-03-06
HUT65278A (en) 1994-05-02
GR3021420T3 (en) 1997-01-31
IL103283A0 (en) 1993-02-21
HU214821B (hu) 1998-06-29
FI924310A (fi) 1993-03-28
CA2079143C (fr) 2004-03-16
EP0534396B1 (fr) 1996-10-09
FI924310A0 (fi) 1992-09-25
AU657793B2 (en) 1995-03-23
NO923745D0 (no) 1992-09-25
KR100271242B1 (ko) 2001-02-01
KR930006028A (ko) 1993-04-20
DE69214397D1 (de) 1996-11-14
EP0534396A2 (fr) 1993-03-31
JP3173674B2 (ja) 2001-06-04
ES2095380T3 (es) 1997-02-16
HU9203075D0 (en) 1992-12-28
JPH05230060A (ja) 1993-09-07
EP0534396A3 (en) 1993-06-09
NO923745L (no) 1993-03-29
NZ244462A (en) 1994-08-26
DK0534396T3 (da) 1996-11-18
FI101302B (fi) 1998-05-29
FI101302B1 (fi) 1998-05-29

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Legal Events

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