IL103276A - One-step process for production of dirithromycin - Google Patents
One-step process for production of dirithromycinInfo
- Publication number
- IL103276A IL103276A IL103276A IL10327692A IL103276A IL 103276 A IL103276 A IL 103276A IL 103276 A IL103276 A IL 103276A IL 10327692 A IL10327692 A IL 10327692A IL 103276 A IL103276 A IL 103276A
- Authority
- IL
- Israel
- Prior art keywords
- dirithromycin
- production
- step process
- or1or2
- erythromycylamine
- Prior art date
Links
- WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 title abstract 2
- 229960004100 dirithromycin Drugs 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- XCLJRCAJSCMIND-JCTYMORFSA-N (9S)-erythromycyclamine Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)[C@@H](N)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 XCLJRCAJSCMIND-JCTYMORFSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76880391A | 1991-09-30 | 1991-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL103276A0 IL103276A0 (en) | 1993-02-21 |
| IL103276A true IL103276A (en) | 1997-06-10 |
Family
ID=25083529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL103276A IL103276A (en) | 1991-09-30 | 1992-09-24 | One-step process for production of dirithromycin |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5578713A (cs) |
| EP (1) | EP0535900B1 (cs) |
| JP (1) | JP3197957B2 (cs) |
| KR (1) | KR100236246B1 (cs) |
| CN (1) | CN1030455C (cs) |
| AR (1) | AR248282A1 (cs) |
| AT (1) | ATE133178T1 (cs) |
| BR (1) | BR9203799A (cs) |
| CA (1) | CA2079430A1 (cs) |
| CZ (1) | CZ281664B6 (cs) |
| DE (1) | DE69207696T2 (cs) |
| DK (1) | DK0535900T3 (cs) |
| ES (1) | ES2083103T3 (cs) |
| FI (1) | FI104969B (cs) |
| GR (1) | GR3018726T3 (cs) |
| HU (1) | HU213620B (cs) |
| IL (1) | IL103276A (cs) |
| MX (1) | MX9205455A (cs) |
| MY (1) | MY113261A (cs) |
| NO (1) | NO178150C (cs) |
| NZ (1) | NZ244495A (cs) |
| PH (1) | PH30959A (cs) |
| RU (1) | RU2045534C1 (cs) |
| SK (1) | SK293592A3 (cs) |
| TW (1) | TW287165B (cs) |
| YU (1) | YU48748B (cs) |
| ZA (1) | ZA927328B (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA966601B (en) * | 1995-08-03 | 1997-02-19 | Chugai Pharmaceutical Co Ltd | Process for producing erythromycin derivatives. |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| AU2004258944B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| AU2004258953B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| EP1648415A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| AU2004264939A1 (en) | 2003-08-11 | 2005-02-24 | Middlebrook Pharmaceuticals, Inc. | Robust pellet |
| US8062672B2 (en) | 2003-08-12 | 2011-11-22 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| JP5686494B2 (ja) * | 2003-08-29 | 2015-03-18 | シオノギ インコーポレイテッド | 抗生物質製剤、その使用法及び作成方法 |
| AU2004273830B2 (en) | 2003-09-15 | 2011-03-24 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| JP2008505124A (ja) | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT342770B (de) * | 1975-04-07 | 1978-04-25 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer erythromycinderivate |
| US4438109A (en) * | 1980-07-25 | 1984-03-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Tylosin derivatives |
| JPS62103098A (ja) * | 1985-05-13 | 1987-05-13 | Microbial Chem Res Found | タイロシン誘導体 |
-
1992
- 1992-09-24 CZ CS922935A patent/CZ281664B6/cs not_active IP Right Cessation
- 1992-09-24 SK SK2935-92A patent/SK293592A3/sk unknown
- 1992-09-24 IL IL103276A patent/IL103276A/xx not_active IP Right Cessation
- 1992-09-24 ZA ZA927328A patent/ZA927328B/xx unknown
- 1992-09-24 MY MYPI92001713A patent/MY113261A/en unknown
- 1992-09-25 MX MX9205455A patent/MX9205455A/es not_active IP Right Cessation
- 1992-09-25 PH PH44995A patent/PH30959A/en unknown
- 1992-09-25 NZ NZ244495A patent/NZ244495A/en unknown
- 1992-09-28 RU SU5052683/04A patent/RU2045534C1/ru not_active IP Right Cessation
- 1992-09-28 AT AT92308839T patent/ATE133178T1/de not_active IP Right Cessation
- 1992-09-28 EP EP92308839A patent/EP0535900B1/en not_active Expired - Lifetime
- 1992-09-28 NO NO923765A patent/NO178150C/no unknown
- 1992-09-28 ES ES92308839T patent/ES2083103T3/es not_active Expired - Lifetime
- 1992-09-28 DE DE69207696T patent/DE69207696T2/de not_active Expired - Fee Related
- 1992-09-28 KR KR1019920017679A patent/KR100236246B1/ko not_active Expired - Fee Related
- 1992-09-28 DK DK92308839.7T patent/DK0535900T3/da active
- 1992-09-29 CN CN92110845A patent/CN1030455C/zh not_active Expired - Fee Related
- 1992-09-29 YU YU87792A patent/YU48748B/sh unknown
- 1992-09-29 BR BR929203799A patent/BR9203799A/pt not_active Application Discontinuation
- 1992-09-29 CA CA002079430A patent/CA2079430A1/en not_active Abandoned
- 1992-09-29 HU HU9203101A patent/HU213620B/hu not_active IP Right Cessation
- 1992-09-29 JP JP26002192A patent/JP3197957B2/ja not_active Expired - Fee Related
- 1992-09-29 FI FI924360A patent/FI104969B/fi active
- 1992-09-29 AR AR92323301A patent/AR248282A1/es active
- 1992-10-27 TW TW081108536A patent/TW287165B/zh active
-
1993
- 1993-07-20 US US08/095,366 patent/US5578713A/en not_active Expired - Fee Related
-
1996
- 1996-01-18 GR GR960400113T patent/GR3018726T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |