ES8600751A1 - Procedimiento de producir derivados de acido oxazolacetico. - Google Patents

Procedimiento de producir derivados de acido oxazolacetico.

Info

Publication number
ES8600751A1
ES8600751A1 ES538030A ES538030A ES8600751A1 ES 8600751 A1 ES8600751 A1 ES 8600751A1 ES 538030 A ES538030 A ES 538030A ES 538030 A ES538030 A ES 538030A ES 8600751 A1 ES8600751 A1 ES 8600751A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
derivatives
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538030A
Other languages
English (en)
Other versions
ES538030A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8600751A1 publication Critical patent/ES8600751A1/es
Publication of ES538030A0 publication Critical patent/ES538030A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/40—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO DE PRODUCIR DERIVADOS DE ACIDO OXAZOLACETICO.CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II) Y ESTERIFICADO SEGUIDAMENTE PARA OBTENER DERIVADOS DE ACIDO OXAZOLACETICO DE FORMULA (I), DONDE R1 SE ELIGE DEL GRUPO FORMADO POR LA FORMULA (III); R2 ES UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA CON C 1 A 6; Y R3 ES H, UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA CON C 1 A 6 O UN GRUPO ARALQUILO.SE UTILIZAN FARMACOLOGICAMENTE COMO ANTIDIABETICOS POR MEJORAR LA TOLERANCIA DE LA GLUCOSA Y POSEER ACTIVIDAD DE POTENCIACION DE LA SENSIBILIDAD A LA INSULINA EN ANIMALES MAMIFEROS.
ES538030A 1982-06-15 1984-11-16 Procedimiento de producir derivados de acido oxazolacetico. Granted ES538030A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57103544A JPS58219169A (ja) 1982-06-15 1982-06-15 オキサゾ−ル酢酸誘導体

Publications (2)

Publication Number Publication Date
ES8600751A1 true ES8600751A1 (es) 1985-11-01
ES538030A0 ES538030A0 (es) 1985-11-01

Family

ID=14356777

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523152A Granted ES523152A0 (es) 1982-06-15 1983-06-10 Procedimiento de producir derivados de acido oxazolacetico
ES538030A Granted ES538030A0 (es) 1982-06-15 1984-11-16 Procedimiento de producir derivados de acido oxazolacetico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523152A Granted ES523152A0 (es) 1982-06-15 1983-06-10 Procedimiento de producir derivados de acido oxazolacetico

Country Status (15)

Country Link
US (1) US4602027A (es)
EP (1) EP0096890B1 (es)
JP (1) JPS58219169A (es)
KR (1) KR840005116A (es)
AU (1) AU1565783A (es)
CA (1) CA1195986A (es)
DE (1) DE3374685D1 (es)
DK (1) DK272083A (es)
ES (2) ES523152A0 (es)
FI (1) FI832036L (es)
GR (1) GR78290B (es)
HU (1) HU189296B (es)
NO (1) NO832146L (es)
PT (1) PT76871B (es)
ZA (1) ZA834307B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531608D0 (en) * 1985-12-23 1986-02-05 Beecham Group Plc Treatment
US5239080A (en) * 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
EP0409418A1 (en) * 1989-07-20 1991-01-23 Imperial Chemical Industries Plc Heterocyclic tertiary alcohols
EP0440183A1 (en) * 1990-02-01 1991-08-07 Takeda Chemical Industries, Ltd. Oxazole compounds, their production and use
JP2829451B2 (ja) * 1990-11-30 1998-11-25 大塚製薬株式会社 活性酸素抑制剤
WO1994001433A1 (en) * 1992-07-13 1994-01-20 Japan Tobacco Inc. Novel thiazolidinedione compound and use thereof
MY128323A (en) 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
CN1781915A (zh) 1998-03-30 2006-06-07 日本烟草产业株式会社 噁唑基乙醇衍生物的制备方法
CA2383524C (en) * 1999-08-31 2010-09-28 Merck & Co., Inc. Thiazolyl alkynyl compounds and methods of use thereof
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401120A (en) * 1965-10-23 1968-09-10 Gaf Corp Corrosion inhibitors
FI53314C (fi) * 1967-06-14 1978-04-10 Wyeth John & Brother Ltd Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-(fenyleller p-klorfenyl) oxazol-4-yl (aettiksyra -acetatsalt eller -acetamid)
GB1245087A (en) * 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
AR208400A1 (es) * 1974-03-13 1976-12-27 Yoshitomi Pharmaceutical Un metodo para producir nuevos acidos 5-alcoxi-4-oxazolalcanoicos 2-substituidos y sus esteres
JPS57188587A (en) * 1981-05-15 1982-11-19 Tanabe Seiyaku Co Ltd Thienyloxazolylacetic acid derivative and its preparation

Also Published As

Publication number Publication date
AU1565783A (en) 1983-12-22
DE3374685D1 (en) 1988-01-07
FI832036L (fi) 1983-12-16
ES8503676A1 (es) 1985-04-01
NO832146L (no) 1983-12-16
PT76871A (en) 1983-07-01
DK272083D0 (da) 1983-06-14
PT76871B (en) 1986-01-27
ZA834307B (en) 1984-03-28
ES523152A0 (es) 1985-04-01
HU189296B (en) 1986-06-30
KR840005116A (ko) 1984-11-03
EP0096890A3 (en) 1984-11-14
EP0096890B1 (en) 1987-11-25
ES538030A0 (es) 1985-11-01
US4602027A (en) 1986-07-22
FI832036A0 (fi) 1983-06-07
EP0096890A2 (en) 1983-12-28
DK272083A (da) 1983-12-16
JPS58219169A (ja) 1983-12-20
CA1195986A (en) 1985-10-29
JPH044312B2 (es) 1992-01-27
GR78290B (es) 1984-09-26

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