IE921945A1 - Imidazodiazepines - Google Patents
ImidazodiazepinesInfo
- Publication number
- IE921945A1 IE921945A1 IE194592A IE921945A IE921945A1 IE 921945 A1 IE921945 A1 IE 921945A1 IE 194592 A IE194592 A IE 194592A IE 921945 A IE921945 A IE 921945A IE 921945 A1 IE921945 A1 IE 921945A1
- Authority
- IE
- Ireland
- Prior art keywords
- benzodiazepine
- triazolo
- imidazo
- fluoro
- oxadiazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH179191 | 1991-06-17 | ||
| CH114092 | 1992-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE921945A1 true IE921945A1 (en) | 1992-12-30 |
Family
ID=25686778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE194592A IE921945A1 (en) | 1991-06-17 | 1992-07-01 | Imidazodiazepines |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5387585A (en:Method) |
| EP (1) | EP0519307A3 (en:Method) |
| JP (1) | JPH078869B2 (en:Method) |
| KR (1) | KR930000517A (en:Method) |
| AU (1) | AU655472B2 (en:Method) |
| CA (1) | CA2069382A1 (en:Method) |
| CZ (1) | CZ185092A3 (en:Method) |
| FI (1) | FI922827A7 (en:Method) |
| HU (1) | HU9201929D0 (en:Method) |
| IE (1) | IE921945A1 (en:Method) |
| IL (1) | IL102175A0 (en:Method) |
| IS (1) | IS3878A (en:Method) |
| NO (1) | NO922367L (en:Method) |
| NZ (1) | NZ243091A (en:Method) |
| TW (1) | TW201311B (en:Method) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW349100B (en) * | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
| JPH10298078A (ja) * | 1997-05-06 | 1998-11-10 | Mitsubishi Chem Corp | 抗不安薬 |
| TWI239333B (en) | 2000-11-16 | 2005-09-11 | Hoffmann La Roche | Benzodiazepine derivatives as GABA A receptor modulators |
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| KR100965201B1 (ko) * | 2001-06-12 | 2010-06-24 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| CA2581918A1 (en) | 2004-10-12 | 2006-04-20 | Henner Knust | Imidazo(1,5-a)triazolo(1,5-d) benzodiazepine deratives for the treatment of cognitive disorders |
| AU2005299031B2 (en) * | 2004-10-20 | 2011-11-10 | F. Hoffmann-La Roche Ag | Halogen substituted benzodiazepine derivatives |
| NZ554439A (en) * | 2004-10-20 | 2009-09-25 | Hoffmann La Roche | Imidazo-benzodiazepine derivatives |
| KR100923393B1 (ko) * | 2004-12-14 | 2009-10-23 | 에프. 호프만-라 로슈 아게 | Ｇａｂａ 수용체 조절제로서 테트라사이클릭이미다조-벤조다이아제핀 |
| ATE477255T1 (de) | 2005-10-11 | 2010-08-15 | Hoffmann La Roche | Imidazobenzdiazepinderivate |
| US9322831B2 (en) | 2008-09-23 | 2016-04-26 | The Johns Hopkins University | DDX3 as a biomarker for cancer and methods related thereto |
| US8518901B2 (en) | 2008-09-23 | 2013-08-27 | The Johns Hopkins University | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
| AU2014240289B2 (en) * | 2008-09-23 | 2015-12-03 | The Johns Hopkins University | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
| EA027840B1 (ru) | 2010-11-15 | 2017-09-29 | Эйджинбайо, Инк. | Производные пиридазина, композиции и способы лечения когнитивного нарушения |
| TR201809838T4 (tr) | 2013-09-06 | 2018-07-23 | Aurigene Discovery Tech Ltd | İmmünomodülatörler olarak 1,2,4-oksadiazol türevleri. |
| MX391314B (es) * | 2013-12-20 | 2025-03-21 | Agenebio Inc | Derivados de benzodiazepina, composiciones, y metodos para tratar el deterioro cognitivo. |
| EP3267984B1 (en) | 2015-03-10 | 2021-11-24 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| MX2017011612A (es) * | 2015-03-10 | 2018-03-23 | Aurigene Discovery Tech Ltd | Compuestos de tiadiazol y 1,2,4-oxadiazol 3-sustituidos como inmunomoduladores. |
| MX392119B (es) | 2015-06-19 | 2025-03-11 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo |
| EP3394056B1 (en) | 2015-12-22 | 2021-04-14 | Shy Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| EP3642209B1 (en) | 2017-06-21 | 2023-11-29 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| US11136300B2 (en) | 2017-10-11 | 2021-10-05 | Aurigene Discovery Technologies Limited | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| JP7378394B2 (ja) | 2017-11-03 | 2023-11-13 | オーリジーン オンコロジー リミテッド | Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤 |
| KR20200084333A (ko) | 2017-11-06 | 2020-07-10 | 오리진 디스커버리 테크놀로지스 리미티드 | 면역조절을 위한 병행 요법 |
| EA202190076A1 (ru) | 2018-06-19 | 2021-09-22 | Эйджинбайо, Инк. | Производные бензодиазепина, композиции и способы лечения когнитивных нарушений |
| WO2020132071A1 (en) | 2018-12-19 | 2020-06-25 | Shy Therapeutics. Llc | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| NZ210850A (en) * | 1984-01-19 | 1988-10-28 | Hoffmann La Roche | Imidazodiazepine derivatives and pharmaceutical compositions |
| US4897392A (en) * | 1989-07-03 | 1990-01-30 | Hoechst-Roussel Pharmaceuticals, Inc. | 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines |
| DK443589D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| DK41191D0 (da) * | 1991-03-07 | 1991-03-07 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og anvendelse |
-
1992
- 1992-05-15 TW TW081103807A patent/TW201311B/zh active
- 1992-05-25 CA CA002069382A patent/CA2069382A1/en not_active Abandoned
- 1992-06-10 HU HU9201929A patent/HU9201929D0/hu unknown
- 1992-06-10 EP EP19920109745 patent/EP0519307A3/de not_active Withdrawn
- 1992-06-10 NZ NZ243091A patent/NZ243091A/en unknown
- 1992-06-11 IL IL102175A patent/IL102175A0/xx unknown
- 1992-06-12 JP JP4179406A patent/JPH078869B2/ja not_active Expired - Lifetime
- 1992-06-12 IS IS3878A patent/IS3878A/is unknown
- 1992-06-12 AU AU18234/92A patent/AU655472B2/en not_active Ceased
- 1992-06-16 KR KR1019920010394A patent/KR930000517A/ko not_active Withdrawn
- 1992-06-16 NO NO92922367A patent/NO922367L/no unknown
- 1992-06-16 CZ CS921850A patent/CZ185092A3/cs unknown
- 1992-06-17 FI FI922827A patent/FI922827A7/fi not_active Application Discontinuation
- 1992-07-01 IE IE194592A patent/IE921945A1/en not_active Application Discontinuation
-
1993
- 1993-11-15 US US08/153,234 patent/US5387585A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH078869B2 (ja) | 1995-02-01 |
| KR930000517A (ko) | 1993-01-15 |
| EP0519307A3 (en) | 1993-04-21 |
| NO922367L (no) | 1992-12-18 |
| AU1823492A (en) | 1992-12-24 |
| IS3878A (is) | 1992-12-18 |
| TW201311B (en:Method) | 1993-03-01 |
| HU9201929D0 (en) | 1992-08-28 |
| EP0519307A2 (de) | 1992-12-23 |
| CZ185092A3 (en) | 1993-12-15 |
| JPH05202051A (ja) | 1993-08-10 |
| NO922367D0 (no) | 1992-06-16 |
| FI922827A7 (fi) | 1992-12-18 |
| AU655472B2 (en) | 1994-12-22 |
| CA2069382A1 (en) | 1992-12-18 |
| NZ243091A (en) | 1994-11-25 |
| US5387585A (en) | 1995-02-07 |
| IL102175A0 (en) | 1993-01-14 |
| FI922827A0 (fi) | 1992-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC9A | Application refused sect. 31(1) |