AU655472B2 - Imidazodiazepines - Google Patents

Imidazodiazepines

Info

Publication number
AU655472B2
AU655472B2 AU18234/92A AU1823492A AU655472B2 AU 655472 B2 AU655472 B2 AU 655472B2 AU 18234/92 A AU18234/92 A AU 18234/92A AU 1823492 A AU1823492 A AU 1823492A AU 655472 B2 AU655472 B2 AU 655472B2
Authority
AU
Australia
Prior art keywords
imidazodiazepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18234/92A
Other languages
English (en)
Other versions
AU1823492A (en
Inventor
Rene Borer
Walter Gassner
Max Gerecke
Emilio Kyburz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU1823492A publication Critical patent/AU1823492A/en
Application granted granted Critical
Publication of AU655472B2 publication Critical patent/AU655472B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU18234/92A 1991-06-17 1992-06-12 Imidazodiazepines Ceased AU655472B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1791/91 1991-06-17
CH179191 1991-06-17
CH1140/92 1992-04-08
CH114092 1992-04-08

Publications (2)

Publication Number Publication Date
AU1823492A AU1823492A (en) 1992-12-24
AU655472B2 true AU655472B2 (en) 1994-12-22

Family

ID=25686778

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18234/92A Ceased AU655472B2 (en) 1991-06-17 1992-06-12 Imidazodiazepines

Country Status (15)

Country Link
US (1) US5387585A (en:Method)
EP (1) EP0519307A3 (en:Method)
JP (1) JPH078869B2 (en:Method)
KR (1) KR930000517A (en:Method)
AU (1) AU655472B2 (en:Method)
CA (1) CA2069382A1 (en:Method)
CZ (1) CZ185092A3 (en:Method)
FI (1) FI922827A7 (en:Method)
HU (1) HU9201929D0 (en:Method)
IE (1) IE921945A1 (en:Method)
IL (1) IL102175A0 (en:Method)
IS (1) IS3878A (en:Method)
NO (1) NO922367L (en:Method)
NZ (1) NZ243091A (en:Method)
TW (1) TW201311B (en:Method)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
JPH10298078A (ja) * 1997-05-06 1998-11-10 Mitsubishi Chem Corp 抗不安薬
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
ES2441874T3 (es) * 2001-06-12 2014-02-06 Wellstat Therapeutics Corporation Compuestos para el tratamiento de trastornos metabólicos
AU2005293820B2 (en) 2004-10-12 2010-11-25 F. Hoffmann-La Roche Ag Imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine derivatives for the treatment of cognitive disorders
WO2006045430A1 (en) * 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Imidazo-benzodiazepine derivatives
JP4751398B2 (ja) * 2004-10-20 2011-08-17 エフ．ホフマン−ラ ロシュ アーゲー ハロゲン置換ベンゾジアゼピン誘導体
WO2006063708A1 (en) * 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
ATE477255T1 (de) * 2005-10-11 2010-08-15 Hoffmann La Roche Imidazobenzdiazepinderivate
AU2009300357B2 (en) * 2008-09-23 2014-07-03 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
AU2014240289B2 (en) * 2008-09-23 2015-12-03 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
EA027840B1 (ru) 2010-11-15 2017-09-29 Эйджинбайо, Инк. Производные пиридазина, композиции и способы лечения когнитивного нарушения
RS57508B1 (sr) 2013-09-06 2018-10-31 Aurigene Discovery Tech Ltd 1,2,4-derivati oksadiazola kao imunomodulatori
CN106068256B (zh) 2013-12-20 2020-10-23 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法
CN114213356A (zh) 2015-03-10 2022-03-22 奥瑞基尼探索技术有限公司 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物
SG11201706902SA (en) * 2015-03-10 2017-09-28 Aurigene Discovery Tech Ltd 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
AU2016378723B2 (en) 2015-12-22 2021-09-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
IL310023B1 (en) 2017-06-21 2025-08-01 SHY Therapeutics LLC Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathologies and fibrotic diseases
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
EP3694841A1 (en) 2017-10-11 2020-08-19 Aurigene Discovery Technologies Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
EA202090746A1 (ru) 2017-11-03 2020-08-17 Ориджен Дискавери Текнолоджис Лимитед Двойные ингибиторы путей tim-3 и pd-1
KR20200084333A (ko) 2017-11-06 2020-07-10 오리진 디스커버리 테크놀로지스 리미티드 면역조절을 위한 병행 요법
CA3104478A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3898609A1 (en) 2018-12-19 2021-10-27 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6429790A (en) * 1989-09-08 1991-04-08 Novo Nordisk A/S Tetracyclic imidazoquinazoline derivatives, preparation and pharmaceutical compositions
AU1414892A (en) * 1991-03-07 1992-10-06 Novo Nordisk A/S Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
DE3587913D1 (de) * 1984-01-19 1994-10-06 Hoffmann La Roche Imidazodiazepin-Derivate.
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6429790A (en) * 1989-09-08 1991-04-08 Novo Nordisk A/S Tetracyclic imidazoquinazoline derivatives, preparation and pharmaceutical compositions
AU1414892A (en) * 1991-03-07 1992-10-06 Novo Nordisk A/S Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0519307A2 (de) 1992-12-23
NO922367L (no) 1992-12-18
JPH05202051A (ja) 1993-08-10
EP0519307A3 (en) 1993-04-21
IS3878A (is) 1992-12-18
KR930000517A (ko) 1993-01-15
NO922367D0 (no) 1992-06-16
CA2069382A1 (en) 1992-12-18
JPH078869B2 (ja) 1995-02-01
FI922827A7 (fi) 1992-12-18
AU1823492A (en) 1992-12-24
IL102175A0 (en) 1993-01-14
NZ243091A (en) 1994-11-25
IE921945A1 (en) 1992-12-30
TW201311B (en:Method) 1993-03-01
US5387585A (en) 1995-02-07
CZ185092A3 (en) 1993-12-15
HU9201929D0 (en) 1992-08-28
FI922827A0 (fi) 1992-06-17

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