IE51172B1 - Process for producing an insulin precursor - Google Patents

Process for producing an insulin precursor

Info

Publication number
IE51172B1
IE51172B1 IE679/81A IE67981A IE51172B1 IE 51172 B1 IE51172 B1 IE 51172B1 IE 679/81 A IE679/81 A IE 679/81A IE 67981 A IE67981 A IE 67981A IE 51172 B1 IE51172 B1 IE 51172B1
Authority
IE
Ireland
Prior art keywords
insulin
chain
moiety
arg
reaction
Prior art date
Application number
IE679/81A
Other languages
English (en)
Other versions
IE810679L (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26832281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE51172(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE810679L publication Critical patent/IE810679L/xx
Publication of IE51172B1 publication Critical patent/IE51172B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IE679/81A 1980-03-27 1981-03-26 Process for producing an insulin precursor IE51172B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13438980A 1980-03-27 1980-03-27
US21069680A 1980-11-28 1980-11-28

Publications (2)

Publication Number Publication Date
IE810679L IE810679L (en) 1981-09-27
IE51172B1 true IE51172B1 (en) 1986-10-29

Family

ID=26832281

Family Applications (1)

Application Number Title Priority Date Filing Date
IE679/81A IE51172B1 (en) 1980-03-27 1981-03-26 Process for producing an insulin precursor

Country Status (23)

Country Link
EP (1) EP0037255B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR840000946B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR224933A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU540644B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1154435A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD157612A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3161475D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK149863C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG15310A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8201957A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI810917A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2073204B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR73517B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU185249B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE51172B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL62486A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO151898C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ196609A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL127843B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT72732B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RO (1) RO81951B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1301319A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU76881A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003413A1 (en) * 1982-03-31 1983-10-13 Genetics Inst Creation of dna sequences encoding modified proinsulin precursors
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE59305396D1 (de) 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten

Also Published As

Publication number Publication date
HU185249B (en) 1984-12-28
FI810917L (fi) 1981-09-28
AU540644B2 (en) 1984-11-29
NO151898C (no) 1985-06-26
PT72732B (en) 1982-03-23
DE3161475D1 (en) 1983-12-29
DD157612A5 (de) 1982-11-24
RO81951B (ro) 1984-02-28
KR830005251A (ko) 1983-08-03
NO151898B (no) 1985-03-18
EG15310A (en) 1985-12-31
EP0037255A1 (en) 1981-10-07
EP0037255B2 (en) 1989-04-05
CA1154435A (en) 1983-09-27
AR224933A1 (es) 1982-01-29
PL230292A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-11-27
GB2073204A (en) 1981-10-14
GB2073204B (en) 1983-09-21
PL127843B1 (en) 1983-11-30
RO81951A (ro) 1984-02-21
GR73517B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-03-08
DK136481A (da) 1981-09-28
DK149863B (da) 1986-10-13
AU6871981A (en) 1981-10-01
IL62486A0 (en) 1981-05-20
NO811039L (no) 1981-09-28
SU1301319A3 (ru) 1987-03-30
IE810679L (en) 1981-09-27
DK149863C (da) 1987-06-01
ES500747A0 (es) 1982-01-16
YU76881A (en) 1984-04-30
IL62486A (en) 1984-12-31
KR840000946B1 (ko) 1984-07-01
EP0037255B1 (en) 1983-11-23
PT72732A (en) 1981-04-01
ES8201957A1 (es) 1982-01-16
FI810917A7 (fi) 1981-09-28
NZ196609A (en) 1984-02-03

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