IE46862B1 - Somatostatin analogues - Google Patents

Somatostatin analogues

Info

Publication number
IE46862B1
IE46862B1 IE511/78A IE51178A IE46862B1 IE 46862 B1 IE46862 B1 IE 46862B1 IE 511/78 A IE511/78 A IE 511/78A IE 51178 A IE51178 A IE 51178A IE 46862 B1 IE46862 B1 IE 46862B1
Authority
IE
Ireland
Prior art keywords
peptide
direct bond
cys
formula
thr
Prior art date
Application number
IE511/78A
Other languages
English (en)
Other versions
IE780511L (en
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of IE780511L publication Critical patent/IE780511L/xx
Publication of IE46862B1 publication Critical patent/IE46862B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IE511/78A 1977-03-28 1978-03-14 Somatostatin analogues IE46862B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/781,580 US4105603A (en) 1977-03-28 1977-03-28 Peptides which effect release of hormones

Publications (2)

Publication Number Publication Date
IE780511L IE780511L (en) 1978-09-28
IE46862B1 true IE46862B1 (en) 1983-10-19

Family

ID=25123228

Family Applications (1)

Application Number Title Priority Date Filing Date
IE511/78A IE46862B1 (en) 1977-03-28 1978-03-14 Somatostatin analogues

Country Status (19)

Country Link
US (1) US4105603A (https=)
JP (1) JPS53130687A (https=)
AT (1) AT366026B (https=)
AU (1) AU519122B2 (https=)
BE (1) BE865380A (https=)
CA (1) CA1102314A (https=)
CH (1) CH639361A5 (https=)
DE (1) DE2813327A1 (https=)
DK (1) DK131878A (https=)
ES (1) ES468241A1 (https=)
FI (1) FI780907A7 (https=)
FR (1) FR2385688A1 (https=)
GB (1) GB1564191A (https=)
IE (1) IE46862B1 (https=)
IT (1) IT1105152B (https=)
LU (1) LU79320A1 (https=)
NL (1) NL7803289A (https=)
SE (1) SE446190B (https=)
ZA (1) ZA781599B (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
US4185010A (en) * 1978-12-12 1980-01-22 American Home Products Corporation Nonapeptides
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
USRE30548E (en) * 1979-08-31 1981-03-17 The Salk Institute For Biological Studies Peptides which effect release of hormones
EP0029579B1 (en) * 1979-11-27 1983-02-16 Sandoz Ag Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
FR2523125A1 (fr) * 1982-03-08 1983-09-16 Sanofi Sa Analogues de la somatostatine a activite biologique modifiee et medicaments en contenant
US4428942A (en) 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
US4443368A (en) * 1982-11-01 1984-04-17 The Salk Institute For Biological Studies Peptides affecting gonadal function
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
DE68922602T2 (de) * 1988-01-28 1995-12-07 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
US6737408B1 (en) 1997-08-07 2004-05-18 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
EP1757311B1 (en) 1999-12-24 2009-02-11 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
EP2180054A1 (en) * 1999-12-24 2010-04-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20040001827A1 (en) * 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
US20060228364A1 (en) * 1999-12-24 2006-10-12 Genentech, Inc. Serum albumin binding peptides for tumor targeting
US20050287153A1 (en) * 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
MXPA06003014A (es) * 2003-09-18 2006-06-23 Raven Biotechnologies Inc Kid3 y anticuerpos de kid3 que se unen a este.
JP4390568B2 (ja) * 2004-01-19 2009-12-24 富士通株式会社 遅延測定システム
KR101295139B1 (ko) * 2004-06-07 2013-08-12 레이븐 바이오테크놀로지스, 인코퍼레이티드 트랜스페린 리셉터 항체
JP2008515889A (ja) * 2004-10-05 2008-05-15 ジェネンテック・インコーポレーテッド 毒性の低下した治療剤
US7687242B2 (en) * 2005-01-12 2010-03-30 Raven Biotechnologies, Inc. KID31 and antibodies that bind thereto
EP1846032A4 (en) * 2005-01-31 2009-01-28 Raven Biotechnologies Inc LUCA2 AND THEREO BINDING ANTIBODIES
WO2006084078A2 (en) * 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
AU2006210589B2 (en) 2005-02-02 2011-12-08 Macrogenics West, Inc. ADAM-9 modulators
EP1846455A4 (en) 2005-02-03 2010-02-17 Raven Biotechnologies Inc ANTIBODY TO THE ONKOSTATIN M RECEPTOR
US20070197445A1 (en) 2006-01-18 2007-08-23 University Of Cincinnati Compounds for control of appetite
US7718774B2 (en) * 2006-11-08 2010-05-18 Macrogenics, Inc. TES7 and antibodies that bind thereto
EP2421551B2 (en) 2009-04-20 2020-07-15 Allergan, Inc. Silk fibroin hydrogels and uses thereof
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
JP5998060B2 (ja) 2010-03-04 2016-09-28 マクロジェニクス，インコーポレーテッド Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
DK2714733T3 (da) 2011-05-21 2019-05-06 Macrogenics Inc Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3
EP2748182B1 (en) 2011-08-23 2016-10-19 President and Fellows of Harvard College Peptide nanoparticles and uses thereof
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
JP6676521B2 (ja) 2013-03-14 2020-04-08 マクロジェニクス，インコーポレーテッド 二重特異性分子、薬学的組成物及びそれらの使用
CA2911613A1 (en) 2013-03-29 2014-10-02 Centre National De La Recherche Scientifique (Cnrs) Cgrp receptor agonist for hiv treatment or prevention
EP3152235B1 (en) 2014-05-29 2021-08-25 MacroGenics, Inc. Tri-specific binding molecules and methods of use thereof
EP3201227A4 (en) 2014-09-29 2018-04-18 Duke University Bispecific molecules comprising an hiv-1 envelope targeting arm
SG11201706024YA (en) 2015-01-26 2017-08-30 Macrogenics Inc Multivalent molecules comprising dr5-binding domains
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
WO2017019846A1 (en) 2015-07-30 2017-02-02 Macrogenics, Inc. Pd-1-binding molecules and methods use thereof
CN108136010A (zh) 2015-10-08 2018-06-08 宏观基因有限公司 用于治疗癌症的联合疗法
KR102815803B1 (ko) 2015-12-02 2025-06-05 주식회사 에스티사이언스 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체
US10954301B2 (en) 2015-12-14 2021-03-23 Macrogenics, Inc. Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法
US10111929B1 (en) 2017-04-07 2018-10-30 Ez Ip, Llc Growth hormone releasing factor analogs and uses
CN114729045B (zh) 2019-09-26 2025-09-09 斯特库比公司 对糖基化的ctla-4特异性的抗体及其使用方法
US12595304B2 (en) 2019-10-09 2026-04-07 Stcube & Co., Inc. Antibodies specific to glycosylated LAG3 and methods of use thereof
US11596665B2 (en) 2020-06-23 2023-03-07 Chanda Zaveri Skin lightening formulations
US11951203B2 (en) 2020-08-26 2024-04-09 Chanda Zaveri Deep wrinkle vanishing compositions
US11793746B2 (en) 2020-10-01 2023-10-24 Chanda Zaveri Intense skin hydration systems and methods
US20220110852A1 (en) 2020-10-14 2022-04-14 Chanda Zaveri Pigment Stabilizers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904594A (en) * 1973-07-02 1975-09-09 Salk Inst For Biological Studi Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
US3842067A (en) * 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
US3917578A (en) * 1973-12-10 1975-11-04 Ayerst Mckenna & Harrison Process for producing somatostatin and intermediates
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4011207A (en) * 1974-12-27 1977-03-08 American Home Products Corporation Des-(Ala1, Gly2,Lys4 -Srif, Des-(Ala1, Gly2, Lys4)-D-Trp8 -Srif and intermediates
US3933784A (en) * 1975-01-27 1976-01-20 American Home Products Corporation Des-(ser13)-srif and intermediates

Also Published As

Publication number Publication date
ES468241A1 (es) 1978-12-01
CA1102314A (en) 1981-06-02
ZA781599B (en) 1979-10-31
FR2385688A1 (fr) 1978-10-27
GB1564191A (en) 1980-04-02
AU519122B2 (en) 1981-11-12
JPS53130687A (en) 1978-11-14
IE780511L (en) 1978-09-28
JPS6141920B2 (https=) 1986-09-18
AU3430778A (en) 1979-09-27
ATA213878A (de) 1981-07-15
FR2385688B1 (https=) 1983-10-07
SE7803318L (sv) 1978-09-29
BE865380A (fr) 1978-07-17
US4105603A (en) 1978-08-08
IT1105152B (it) 1985-10-28
NL7803289A (nl) 1978-10-02
CH639361A5 (de) 1983-11-15
IT7848586A0 (it) 1978-03-23
AT366026B (de) 1982-03-10
DE2813327C2 (https=) 1988-08-18
DK131878A (da) 1978-09-29
FI780907A7 (fi) 1978-09-29
DE2813327A1 (de) 1978-10-05
SE446190B (sv) 1986-08-18
LU79320A1 (fr) 1978-06-29

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