IE42308B1 - 16, 16-disubstituted steroids of the androstene series - Google Patents

16, 16-disubstituted steroids of the androstene series

Info

Publication number
IE42308B1
IE42308B1 IE412/76A IE41276A IE42308B1 IE 42308 B1 IE42308 B1 IE 42308B1 IE 412/76 A IE412/76 A IE 412/76A IE 41276 A IE41276 A IE 41276A IE 42308 B1 IE42308 B1 IE 42308B1
Authority
IE
Ireland
Prior art keywords
group
compound according
compound
formula
carbon atoms
Prior art date
Application number
IE412/76A
Other languages
English (en)
Other versions
IE42308L (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE42308L publication Critical patent/IE42308L/xx
Publication of IE42308B1 publication Critical patent/IE42308B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
IE412/76A 1975-03-21 1976-03-01 16, 16-disubstituted steroids of the androstene series IE42308B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11819/75A GB1538227A (en) 1975-03-21 1975-03-21 16,16-disubstituted steroids of the androstene series

Publications (2)

Publication Number Publication Date
IE42308L IE42308L (en) 1976-09-21
IE42308B1 true IE42308B1 (en) 1980-07-16

Family

ID=9993275

Family Applications (1)

Application Number Title Priority Date Filing Date
IE412/76A IE42308B1 (en) 1975-03-21 1976-03-01 16, 16-disubstituted steroids of the androstene series

Country Status (15)

Country Link
JP (2) JPS51118756A (cs)
AT (1) AT357700B (cs)
AU (1) AU501246B2 (cs)
BE (1) BE839751A (cs)
CA (1) CA1069498A (cs)
CH (2) CH621560A5 (cs)
DE (1) DE2610497C2 (cs)
DK (1) DK143757C (cs)
FR (2) FR2304345A1 (cs)
GB (1) GB1538227A (cs)
IE (1) IE42308B1 (cs)
IL (2) IL49132A (cs)
NL (1) NL184111C (cs)
SE (2) SE7603410L (cs)
ZA (1) ZA761324B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602960A (en) * 1977-05-25 1981-11-18 Beecham Group Ltd Process for preparing 16,16-disubstituted steroids of the androstene series
DE2943778A1 (de) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
DE3514272A1 (de) * 1985-04-17 1986-10-23 Schering AG, 1000 Berlin und 4709 Bergkamen Dermatica
JPS63300153A (ja) * 1987-05-29 1988-12-07 日本碍子株式会社 建築用ほうろうパネル
GB9021546D0 (en) * 1990-10-04 1990-11-21 Beecham Group Plc Novel composition
WO1992007586A1 (en) * 1990-10-31 1992-05-14 Beecham Group Plc Topical composition with retinoid penetration enhancer
GB9205194D0 (en) * 1992-03-10 1992-04-22 Smithkline Beecham Plc Novel composition
WO2003051903A1 (fr) * 2001-12-19 2003-06-26 Chugai Seiyaku Kabushiki Kaisha Derive de l'androstane renfermant un substituant en position 7 et 17
CN108558975B (zh) * 2018-04-26 2021-03-02 昆明理工大学 12β-羟基-雄甾4,14-二烯-16-酮类化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853926A (en) * 1973-05-29 1974-12-10 Searle & Co 17{62 -hydroxy-16,16-dimethylester-4-en-3-one

Also Published As

Publication number Publication date
CH621560A5 (en) 1981-02-13
DK143757B (da) 1981-10-05
CA1069498A (en) 1980-01-08
GB1538227A (en) 1979-01-10
JPS6355488B2 (cs) 1988-11-02
ZA761324B (en) 1977-02-23
FR2304345A1 (fr) 1976-10-15
FR2445340A1 (fr) 1980-07-25
NL184111B (nl) 1988-11-16
SE7902256L (sv) 1979-03-13
IE42308L (en) 1976-09-21
NL7602949A (nl) 1976-09-23
JPS61178920A (ja) 1986-08-11
AT357700B (de) 1980-07-25
IL58505A0 (en) 1980-01-31
FR2304345B1 (cs) 1980-11-07
IL49132A (en) 1980-05-30
ATA191376A (de) 1979-12-15
AU1220776A (en) 1977-09-22
IL49132A0 (en) 1976-05-31
JPS625920B2 (cs) 1987-02-07
AU501246B2 (en) 1979-06-14
DK143757C (da) 1982-03-22
NL184111C (nl) 1989-04-17
JPS51118756A (en) 1976-10-18
FR2445340B1 (cs) 1983-02-11
DE2610497A1 (de) 1976-10-07
SE7603410L (sv) 1976-09-22
BE839751A (fr) 1976-09-20
CH631996A5 (en) 1982-09-15
DE2610497C2 (de) 1986-10-16
DK123476A (da) 1976-09-22

Similar Documents

Publication Publication Date Title
US4344941A (en) Antiandrogenic 17α-substituted steroids
US5494914A (en) Inhibitors for testosterone 5α-reductase activity
CA2023008C (en) 4-substituted 17.beta. -(cyclopropyloxy)androst-5-en-3.beta.-ol and related compounds useful as c17-20 lyase inhibitors
DE2633925A1 (de) Topisch anwendbare steroidzusammensetzung
IE42308B1 (en) 16, 16-disubstituted steroids of the androstene series
EP0129500A2 (de) 1-Alkyl-androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
US3917829A (en) Novel methods of inhibiting the activity of testosterone 5{60 -reductase
US4891367A (en) 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5866558A (en) 6-alkynyl steroids
US4673673A (en) 17α-alkyl-17β-hydroxy-1α-methyl-4-androsten-3-ones, their production and use pharmaceutically
Solo et al. 7α-Alkyltestosterone derivatives: Synthesis and activity as androgens and as aromatase inhibitors
GB2127827A (en) Pregnane compounds
US4328221A (en) Substituted steroid-spiro-oxazolidinone derivatives and a process for the preparation thereof
JPH04501409A (ja) 抗アンドロゲン化合物
EP0286578A1 (de) 4,15-Disubstituierte 4-Androsten-3,17-dione und Verfahren zu deren Herstellung
CA1069496A (en) Intermediates for pharmaceutically active steroids
US4456620A (en) D-Homo-4,17-androstadien-3-one, its preparation and pharmaceutical use
US3818055A (en) 17-(aralkylaminoalkyl)androstan-3b-ols, 5 derivatives thereof, ethers and esters corresponding
DE2100319B2 (de) Neue Östranverbindungen, ihre Herstellung und sie enthaltende Arzneimittel
EP0277910A1 (de) 1-Methyl-15Alpha-(1,2-dialkanoyloxyalkyl)-androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
SI8611201A8 (sl) Postopek za pridobivanje substituiranih androsta -1,4-dien-3,17-dionov