IE41582L - 4-(2, 4-difluorophenyl) phenol derivatives. - Google Patents

4-(2, 4-difluorophenyl) phenol derivatives.

Info

Publication number
IE41582L
IE41582L IE751582A IE158275A IE41582L IE 41582 L IE41582 L IE 41582L IE 751582 A IE751582 A IE 751582A IE 158275 A IE158275 A IE 158275A IE 41582 L IE41582 L IE 41582L
Authority
IE
Ireland
Prior art keywords
difluorophenyl
formula
compound
stage
phenol derivatives
Prior art date
Application number
IE751582A
Other versions
IE41582B1 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to IE633/78A priority Critical patent/IE41583B1/en
Publication of IE41582L publication Critical patent/IE41582L/en
Publication of IE41582B1 publication Critical patent/IE41582B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

5-(2,4-Difluorophenyl)-salicylic acid of the formula I <IMAGE> is obtained when a) a 4-(2,4-difluorophenyl)-oxo-C1-C4-alkyl compound (II) is oxidised to a corresponding ester, the latter is hydrolysed, in stage b), to give 4-(2,4-difluorophenyl)-phenol and finally, in stage c), the carboxyl group is introduced into the ring carrying the hydroxyl group. The compound of the formula (II) is prepared by reacting a 2,4-difluorobenzenediazonium salt with benzene or a benzenediazonium salt with 2,4-difluorobenzene and acylating the resulting 2,4-difluorobiphenyl. The compound of formula I can be used as an anti-inflammatory, antipyretic and analgesic agent. [GB1496231A]
IE1582/75A 1974-07-22 1975-07-16 4-(2,4-difluorophenyl )phenol derivatives IE41582B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE633/78A IE41583B1 (en) 1974-07-22 1975-07-16 Preparation of 2,4 - diflurobiphenyl

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (2)

Publication Number Publication Date
IE41582L true IE41582L (en) 1976-01-22
IE41582B1 IE41582B1 (en) 1980-02-13

Family

ID=27413871

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1582/75A IE41582B1 (en) 1974-07-22 1975-07-16 4-(2,4-difluorophenyl )phenol derivatives

Country Status (11)

Country Link
JP (1) JPS5134135A (en)
CH (1) CH615146A5 (en)
DE (1) DE2532559C3 (en)
DK (1) DK145643C (en)
FR (1) FR2288729A1 (en)
GB (2) GB1496232A (en)
IE (1) IE41582B1 (en)
LU (1) LU73032A1 (en)
NL (1) NL188689C (en)
NO (1) NO143874C (en)
SE (1) SE428560B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (en) * 1980-10-21 1986-07-24 D & D Srl PYRIDOXY DERIVATIVES FOR THERAPEUTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (en) * 1992-04-06 1993-11-09 株式会社エースプレミアム Traveling toys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (en) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (en) * 1972-05-31 1974-02-13

Also Published As

Publication number Publication date
NL7508127A (en) 1976-01-26
DK310075A (en) 1976-01-23
NO143874B (en) 1981-01-19
JPS5134135A (en) 1976-03-23
NL188689C (en) 1992-09-01
FR2288729B1 (en) 1977-12-09
DK145643B (en) 1983-01-10
GB1496231A (en) 1977-12-30
NL188689B (en) 1992-04-01
JPS569496B2 (en) 1981-03-02
DE2532559A1 (en) 1976-02-05
SE7507764L (en) 1976-01-23
FR2288729A1 (en) 1976-05-21
SE428560B (en) 1983-07-11
DE2532559C3 (en) 1979-10-04
CH615146A5 (en) 1980-01-15
LU73032A1 (en) 1976-07-01
NO752482L (en) 1976-01-23
DE2532559B2 (en) 1979-02-15
IE41582B1 (en) 1980-02-13
NO143874C (en) 1981-04-29
DK145643C (en) 1983-07-11
GB1496232A (en) 1977-12-30

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