SE7507764L - PROCEDURE FOR THE PREPARATION OF 5- (2,4-DIFLUOROPHENYL) SALICYLIC ACID. - Google Patents

PROCEDURE FOR THE PREPARATION OF 5- (2,4-DIFLUOROPHENYL) SALICYLIC ACID.

Info

Publication number
SE7507764L
SE7507764L SE7507764A SE7507764A SE7507764L SE 7507764 L SE7507764 L SE 7507764L SE 7507764 A SE7507764 A SE 7507764A SE 7507764 A SE7507764 A SE 7507764A SE 7507764 L SE7507764 L SE 7507764L
Authority
SE
Sweden
Prior art keywords
difluorophenyl
procedure
preparation
salicylic acid
acid
Prior art date
Application number
SE7507764A
Other languages
Swedish (sv)
Other versions
SE428560B (en
Inventor
H Jones
R W Houser
R Utne
R B Jobson
A V Lovell
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7507764L publication Critical patent/SE7507764L/en
Publication of SE428560B publication Critical patent/SE428560B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1496232 2,4-Difluorobiphenyl MERCK & CO Inc 16 July 1975 [22 July 1974 16 April 1975 1 May 1975] 06938/77 Divided out of 1496231 Heading C2C 2,4 - Difluorobiphenyl is prepared as in reaction of where X<SP>(-)</SP> is the anion of a mineral acid or a strong organic acid in the presence of a finely divided solid copper powder or copper salt and optionally in the presence of a strong organic acid for 1 to 20 hours at a temperature in the range 5‹ C. to reflux temperature. 2,4, - Difluorobenzenediazonium fluorborate was prepared by adding a nitrite to 2,4-difluoroanaline and fluoboric acid.
SE7507764A 1974-07-22 1975-07-07 PROCEDURE FOR PREPARING 5- (2,4-DIFLUOROPHENYL) SALICYLIC ACID. SE428560B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (2)

Publication Number Publication Date
SE7507764L true SE7507764L (en) 1976-01-23
SE428560B SE428560B (en) 1983-07-11

Family

ID=27413871

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7507764A SE428560B (en) 1974-07-22 1975-07-07 PROCEDURE FOR PREPARING 5- (2,4-DIFLUOROPHENYL) SALICYLIC ACID.

Country Status (11)

Country Link
JP (1) JPS5134135A (en)
CH (1) CH615146A5 (en)
DE (1) DE2532559C3 (en)
DK (1) DK145643C (en)
FR (1) FR2288729A1 (en)
GB (2) GB1496231A (en)
IE (1) IE41582B1 (en)
LU (1) LU73032A1 (en)
NL (1) NL188689C (en)
NO (1) NO143874C (en)
SE (1) SE428560B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (en) * 1980-10-21 1986-07-24 D & D Srl PYRIDOXY DERIVATIVES FOR THERAPEUTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (en) * 1992-04-06 1993-11-09 株式会社エースプレミアム Traveling toys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (en) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (en) * 1972-05-31 1974-02-13

Also Published As

Publication number Publication date
SE428560B (en) 1983-07-11
NL188689B (en) 1992-04-01
NO752482L (en) 1976-01-23
FR2288729A1 (en) 1976-05-21
IE41582B1 (en) 1980-02-13
GB1496231A (en) 1977-12-30
CH615146A5 (en) 1980-01-15
DE2532559C3 (en) 1979-10-04
IE41582L (en) 1976-01-22
DK145643C (en) 1983-07-11
NO143874B (en) 1981-01-19
DK145643B (en) 1983-01-10
GB1496232A (en) 1977-12-30
JPS5134135A (en) 1976-03-23
LU73032A1 (en) 1976-07-01
DE2532559A1 (en) 1976-02-05
DK310075A (en) 1976-01-23
NO143874C (en) 1981-04-29
NL7508127A (en) 1976-01-26
DE2532559B2 (en) 1979-02-15
NL188689C (en) 1992-09-01
JPS569496B2 (en) 1981-03-02
FR2288729B1 (en) 1977-12-09

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