NL7508127A - PROCESS FOR PREPARING 5- (2,4.-DIFLUOROPHENYL) -SALICYLIC ACID. - Google Patents

PROCESS FOR PREPARING 5- (2,4.-DIFLUOROPHENYL) -SALICYLIC ACID.

Info

Publication number
NL7508127A
NL7508127A NL7508127A NL7508127A NL7508127A NL 7508127 A NL7508127 A NL 7508127A NL 7508127 A NL7508127 A NL 7508127A NL 7508127 A NL7508127 A NL 7508127A NL 7508127 A NL7508127 A NL 7508127A
Authority
NL
Netherlands
Prior art keywords
difluorophenyl
preparing
salicylic acid
salicylic
acid
Prior art date
Application number
NL7508127A
Other languages
Dutch (nl)
Other versions
NL188689B (en
NL188689C (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7508127A publication Critical patent/NL7508127A/en
Publication of NL188689B publication Critical patent/NL188689B/en
Application granted granted Critical
Publication of NL188689C publication Critical patent/NL188689C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
NLAANVRAGE7508127,A 1974-07-22 1975-07-08 PROCESS FOR PREPARING 5- (2,4-DIFLUORPHENYL) SALICYLIC ACID. NL188689C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (3)

Publication Number Publication Date
NL7508127A true NL7508127A (en) 1976-01-26
NL188689B NL188689B (en) 1992-04-01
NL188689C NL188689C (en) 1992-09-01

Family

ID=27413871

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7508127,A NL188689C (en) 1974-07-22 1975-07-08 PROCESS FOR PREPARING 5- (2,4-DIFLUORPHENYL) SALICYLIC ACID.

Country Status (11)

Country Link
JP (1) JPS5134135A (en)
CH (1) CH615146A5 (en)
DE (1) DE2532559C3 (en)
DK (1) DK145643C (en)
FR (1) FR2288729A1 (en)
GB (2) GB1496232A (en)
IE (1) IE41582B1 (en)
LU (1) LU73032A1 (en)
NL (1) NL188689C (en)
NO (1) NO143874C (en)
SE (1) SE428560B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (en) * 1980-10-21 1986-07-24 D & D Srl PYRIDOXY DERIVATIVES FOR THERAPEUTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (en) * 1992-04-06 1993-11-09 株式会社エースプレミアム Traveling toys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (en) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (en) * 1972-05-31 1974-02-13

Also Published As

Publication number Publication date
SE7507764L (en) 1976-01-23
NL188689B (en) 1992-04-01
JPS5134135A (en) 1976-03-23
FR2288729B1 (en) 1977-12-09
CH615146A5 (en) 1980-01-15
SE428560B (en) 1983-07-11
FR2288729A1 (en) 1976-05-21
NO752482L (en) 1976-01-23
DE2532559B2 (en) 1979-02-15
NO143874C (en) 1981-04-29
DE2532559C3 (en) 1979-10-04
IE41582B1 (en) 1980-02-13
DK145643B (en) 1983-01-10
DK310075A (en) 1976-01-23
DE2532559A1 (en) 1976-02-05
NL188689C (en) 1992-09-01
JPS569496B2 (en) 1981-03-02
NO143874B (en) 1981-01-19
IE41582L (en) 1976-01-22
LU73032A1 (en) 1976-07-01
GB1496232A (en) 1977-12-30
DK145643C (en) 1983-07-11
GB1496231A (en) 1977-12-30

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Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
V4 Discontinued because of reaching the maximum lifetime of a patent

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