IE40310B1 - N-(3-alkanoyl-4-(3-amino-2-hydroxy)propoxy-phenyl) ureal, methods for their preparation and compositions containing them - Google Patents

N-(3-alkanoyl-4-(3-amino-2-hydroxy)propoxy-phenyl) ureal, methods for their preparation and compositions containing them

Info

Publication number
IE40310B1
IE40310B1 IE2585/74A IE258574A IE40310B1 IE 40310 B1 IE40310 B1 IE 40310B1 IE 2585/74 A IE2585/74 A IE 2585/74A IE 258574 A IE258574 A IE 258574A IE 40310 B1 IE40310 B1 IE 40310B1
Authority
IE
Ireland
Prior art keywords
formula
hydroxy
phenyl
carbon atoms
propoxyj
Prior art date
Application number
IE2585/74A
Other languages
English (en)
Other versions
IE40310L (en
Original Assignee
Chemie Linz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Ag filed Critical Chemie Linz Ag
Publication of IE40310L publication Critical patent/IE40310L/en
Publication of IE40310B1 publication Critical patent/IE40310B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE2585/74A 1973-12-20 1974-12-16 N-(3-alkanoyl-4-(3-amino-2-hydroxy)propoxy-phenyl) ureal, methods for their preparation and compositions containing them IE40310B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1066673A AT334385B (de) 1973-12-20 1973-12-20 Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen

Publications (2)

Publication Number Publication Date
IE40310L IE40310L (en) 1975-06-20
IE40310B1 true IE40310B1 (en) 1979-04-25

Family

ID=3623884

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2585/74A IE40310B1 (en) 1973-12-20 1974-12-16 N-(3-alkanoyl-4-(3-amino-2-hydroxy)propoxy-phenyl) ureal, methods for their preparation and compositions containing them

Country Status (19)

Country Link
US (1) US4034009A (cg-RX-API-DMAC7.html)
JP (2) JPS5412461B2 (cg-RX-API-DMAC7.html)
AT (1) AT334385B (cg-RX-API-DMAC7.html)
BE (1) BE823411A (cg-RX-API-DMAC7.html)
CA (1) CA1001626A (cg-RX-API-DMAC7.html)
CH (1) CH612417A5 (cg-RX-API-DMAC7.html)
CS (1) CS185669B2 (cg-RX-API-DMAC7.html)
DD (1) DD118421A1 (cg-RX-API-DMAC7.html)
ES (1) ES433145A1 (cg-RX-API-DMAC7.html)
FR (1) FR2255058B1 (cg-RX-API-DMAC7.html)
GB (1) GB1441359A (cg-RX-API-DMAC7.html)
IE (1) IE40310B1 (cg-RX-API-DMAC7.html)
IL (1) IL46259A (cg-RX-API-DMAC7.html)
LU (2) LU71514A1 (cg-RX-API-DMAC7.html)
PL (1) PL94095B1 (cg-RX-API-DMAC7.html)
RO (1) RO69147A (cg-RX-API-DMAC7.html)
SU (1) SU547174A3 (cg-RX-API-DMAC7.html)
YU (1) YU36492B (cg-RX-API-DMAC7.html)
ZA (1) ZA748067B (cg-RX-API-DMAC7.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177280A (en) * 1978-07-03 1979-12-04 Syntex (U.S.A.) Inc. Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents
JPS5757231U (cg-RX-API-DMAC7.html) * 1980-09-19 1982-04-03
US4470965A (en) * 1982-10-27 1984-09-11 Usv Pharmaceutical Corporation Celiprolol for the treatment of glaucoma
DE3410380A1 (de) * 1984-03-21 1985-10-10 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München S(-)-celiprolol, dessen pharmazeutisch vertraegliche salze, verfahren zu dessen herstellung, verwendung in der therapie und pharmazeutische zubereitungen
DE3544172A1 (de) * 1985-12-13 1987-06-19 Lentia Gmbh Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung
DE3636209A1 (de) * 1986-10-24 1988-04-28 Lentia Gmbh Verfahren zur herstellung eines bindemittelfreien tablettierfaehigen celiprololhydrochlorid-granulates
OA12905A (en) 2002-08-19 2006-10-13 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
RS20050890A (sr) * 2003-05-30 2007-12-31 Ranbaxy Laboratories Limited, Supstituisani pirol derivati
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
WO2007029155A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited An improved process for preparation of pure celiprolol base
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
WO2007054896A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CL2007000667A1 (es) * 2006-03-14 2008-03-14 Ranbaxi Lab Ltd Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e
MX2009000439A (es) * 2006-07-14 2009-02-04 Ranbaxy Lab Ltd Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8987262B2 (en) 2007-10-19 2015-03-24 Universite de Bordeaux Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
EP2050441A1 (en) 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1214012A (en) * 1967-12-21 1970-11-25 Allen & Hanburys Ltd Phenylethanolamines
AT292671B (de) * 1967-12-22 1971-09-10 May & Baker Ltd Verfahren zur Herstellung von neuen 3-(4'-Alkanoylamino-2'-acylphenoxy)-2-hydroxy-1-aminopropanen
US3935259A (en) * 1970-01-08 1976-01-27 Ciba-Geigy Corporation New amines and processes for their manufacture
SE354851B (cg-RX-API-DMAC7.html) * 1970-02-18 1973-03-26 Haessle Ab
NL7115581A (cg-RX-API-DMAC7.html) * 1970-11-13 1972-05-16 Dresden Arzneimittel
GB1396322A (en) * 1971-06-15 1975-06-04 Ici Ltd Alkanolamine derivatives
GB1393675A (en) 1971-06-16 1975-05-07 Ici Ltd Alkanolamine derivatives
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
GB1455116A (en) * 1972-12-15 1976-11-10 Ici Ltd Pharmaceutical compositions
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
GB1460593A (en) * 1973-06-22 1977-01-06 Ici Ltd Ethanolamine derivatives
FI65987C (fi) * 1973-12-12 1984-08-10 Ici Ltd Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alkanolaminderivat
AT334386B (de) * 1973-12-21 1976-01-10 Chemie Linz Ag Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen

Also Published As

Publication number Publication date
JPS5549071B2 (cg-RX-API-DMAC7.html) 1980-12-10
IL46259A0 (en) 1975-03-13
YU36492B (en) 1984-02-29
AT334385B (de) 1976-01-10
ATA1066673A (de) 1976-05-15
PL94095B1 (cg-RX-API-DMAC7.html) 1977-07-30
DD118421A1 (cg-RX-API-DMAC7.html) 1976-03-05
JPS5412461B2 (cg-RX-API-DMAC7.html) 1979-05-23
ES433145A1 (es) 1976-11-16
CH612417A5 (cg-RX-API-DMAC7.html) 1979-07-31
RO69147A (ro) 1981-07-30
FR2255058A1 (cg-RX-API-DMAC7.html) 1975-07-18
BE823411A (fr) 1975-06-16
CS185669B2 (en) 1978-10-31
CA1001626A (en) 1976-12-14
GB1441359A (en) 1976-06-30
LU71514A1 (cg-RX-API-DMAC7.html) 1975-08-20
IE40310L (en) 1975-06-20
YU327774A (en) 1982-02-25
ZA748067B (en) 1976-01-28
LU88296I2 (fr) 1994-05-04
US4034009A (en) 1977-07-05
IL46259A (en) 1978-04-30
AU7653874A (en) 1976-06-17
JPS5095246A (cg-RX-API-DMAC7.html) 1975-07-29
JPS53149947A (en) 1978-12-27
FR2255058B1 (cg-RX-API-DMAC7.html) 1978-07-28
SU547174A3 (ru) 1977-02-15

Similar Documents

Publication Publication Date Title
IE40310B1 (en) N-(3-alkanoyl-4-(3-amino-2-hydroxy)propoxy-phenyl) ureal, methods for their preparation and compositions containing them
US4296105A (en) Derivatives of doxorubicine, their preparation and use
EP0079022A2 (de) Derivate der cis, endo-2-Azabicyclo-(3.3.0)-octan-3-carbonsäure, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
EP0080822A1 (en) Anti-hypertensive prolinol-based peptides
EP0109020A2 (de) Neue Derivate tricyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung, sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung
JPH0780882B2 (ja) ６‐チオキサンチン誘導体
EP0480061B1 (en) Hepatic disorder inhibitor
EP0218027B1 (en) Novel guanidinomethylbenzoic acid derivatives
US4310666A (en) Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones
US4062870A (en) Chroman derivatives
DE69511163T2 (de) Tocopherolderivate
GB2211501A (en) Antihypertensive benzopyran derivatives
HU184271B (en) Process for preparing imidazolidine derivatives
US4327099A (en) Pyrano derivatives, a process for their preparation and their use
IE43660B1 (en) 3-phenyl-n-phenylsulphenyl spiro/isobenzofuran-1,4'-piperidine/and derivatives thereof
IE44588B1 (en) Trans-4-heterocyclyl-3,4-dihidro-2h-benzo(b)pyran-3-ol esters
FI56522C (fi) Nytt foerfarande foer framstaellning av n-(trans-4-hydroksy-syklohexyl)-(2-amino-3,5-dibrom-benzyl)-amin
DE2640618A1 (de) Mittel zur foerderung des wachstums oder zur verbesserung der wirksamkeit der futterumwandlung bei tieren
US2502264A (en) Quinoline derivatives having antimalarial properties
DE2729165C2 (de) Phenäthylaminderivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CA1217485A (fr) Amino-2 aminomethyl-5 oxazolines-2, leur methode de preparation ainsi que leur application therapeutique
EP0113880A2 (de) Neue 2-Azabicyclo(2.2.1)heptan-Derivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie 2-Azabicyclo(2.2.1)heptan-Derivate als Zwischenprodukte und Verfahren zu deren Herstellung
CA1040640A (en) Indazole-3-carboxylic acid hydrazides and a process for the preparation thereof
US3454629A (en) Novel phenylalanine compounds
US3879411A (en) Ditetrazolyl-benzodipyrans

Legal Events

Date Code Title Description
SPCF Request for grant of supplementary protection certificate

Free format text: SPC 15/93:19930331

SPCF Request for grant of supplementary protection certificate

Free format text: ERRATUM: SPC 15/93 MARKET AUTHORISATION TO READ: GERMANY 2962.00.00 AND 2962.01.00 14 APRIL 1986.

SPCG Supplementary protection certificate granted

Free format text: SPC 15/93 EXPIRES:19991215

MK9A Patent expired