IE39263B1 - Naphthyridine derivatives - Google Patents
Naphthyridine derivativesInfo
- Publication number
- IE39263B1 IE39263B1 IE1012/74A IE101274A IE39263B1 IE 39263 B1 IE39263 B1 IE 39263B1 IE 1012/74 A IE1012/74 A IE 1012/74A IE 101274 A IE101274 A IE 101274A IE 39263 B1 IE39263 B1 IE 39263B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- alkyl
- reaction
- prepared
- naphthyridine
- Prior art date
Links
- 150000005054 naphthyridines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 1
- WLEQWVIWIDRMKX-UHFFFAOYSA-N 7-methoxy-1,8-naphthyridin-2-amine Chemical compound C1=CC(N)=NC2=NC(OC)=CC=C21 WLEQWVIWIDRMKX-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- VIIPRKFEGDDHCU-UHFFFAOYSA-N n-(7-chloro-1,8-naphthyridin-2-yl)acetamide Chemical compound C1=CC(Cl)=NC2=NC(NC(=O)C)=CC=C21 VIIPRKFEGDDHCU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7317516A FR2229400A1 (en) | 1973-05-15 | 1973-05-15 | 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants |
| FR7408730A FR2263752A1 (en) | 1974-03-14 | 1974-03-14 | 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants |
| FR7408728A FR2286642A2 (fr) | 1974-03-14 | 1974-03-14 | Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39263L IE39263L (en) | 1974-11-15 |
| IE39263B1 true IE39263B1 (en) | 1978-08-30 |
Family
ID=27250114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1012/74A IE39263B1 (en) | 1973-05-15 | 1974-05-13 | Naphthyridine derivatives |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5758345B2 (en, 2012) |
| AR (2) | AR209421A1 (en, 2012) |
| AT (1) | AT336030B (en, 2012) |
| CH (2) | CH592662A5 (en, 2012) |
| CS (1) | CS191881B2 (en, 2012) |
| DD (1) | DD111078A5 (en, 2012) |
| DE (1) | DE2423650A1 (en, 2012) |
| DK (1) | DK136819B (en, 2012) |
| ES (2) | ES426336A1 (en, 2012) |
| FI (1) | FI55659C (en, 2012) |
| GB (1) | GB1417935A (en, 2012) |
| HU (1) | HU169609B (en, 2012) |
| IE (1) | IE39263B1 (en, 2012) |
| IL (1) | IL44815A (en, 2012) |
| LU (1) | LU70071A1 (en, 2012) |
| NL (1) | NL7406194A (en, 2012) |
| NO (1) | NO140012C (en, 2012) |
| OA (1) | OA04700A (en, 2012) |
| PH (1) | PH11400A (en, 2012) |
| PL (1) | PL90061B1 (en, 2012) |
| SE (1) | SE410857B (en, 2012) |
| SU (2) | SU583757A3 (en, 2012) |
| YU (2) | YU133674A (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS537455B1 (en, 2012) * | 1971-02-01 | 1978-03-17 | ||
| FR2324305A2 (fr) * | 1975-09-22 | 1977-04-15 | Rhone Poulenc Ind | Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent |
| AR208414A1 (es) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
| FR2322600A1 (fr) * | 1975-09-04 | 1977-04-01 | Rhone Poulenc Ind | Nouveaux derives de la pyrrolo (3,4-b) pyrazine, leur preparation et les compositions qui les contiennent |
| OA05287A (fr) * | 1975-04-07 | 1981-02-28 | Rhone Poulenc Ind | Nouveaux composés hétérocycliques et leur préparation. |
| JPS5546256A (en) * | 1978-09-27 | 1980-03-31 | Hitachi Cable | Flame retardant insulated wire |
| JPS5546257A (en) * | 1978-09-27 | 1980-03-31 | Hitachi Cable | Flame retardant cable |
| JPS63191981U (en, 2012) * | 1987-05-30 | 1988-12-09 | ||
| SK282252B6 (sk) * | 1995-01-11 | 2001-12-03 | Samjin Pharmaceutical Co., Ltd. | Piperazínové deriváty a farmaceutický prostriedok s ich obsahom |
| ATE241600T1 (de) * | 1996-06-29 | 2003-06-15 | Samjin Pharm Co Ltd | Piperazin-derivate und verfahren zu ihrer herstellung |
-
1974
- 1974-04-29 OA OA55189A patent/OA04700A/xx unknown
- 1974-04-30 PH PH15794A patent/PH11400A/en unknown
- 1974-05-08 NL NL7406194A patent/NL7406194A/xx not_active Application Discontinuation
- 1974-05-13 JP JP49052378A patent/JPS5758345B2/ja not_active Expired
- 1974-05-13 IL IL44815A patent/IL44815A/en unknown
- 1974-05-13 HU HURO780A patent/HU169609B/hu unknown
- 1974-05-13 GB GB2108174A patent/GB1417935A/en not_active Expired
- 1974-05-13 IE IE1012/74A patent/IE39263B1/xx unknown
- 1974-05-14 LU LU70071A patent/LU70071A1/xx unknown
- 1974-05-14 CH CH659574A patent/CH592662A5/xx not_active IP Right Cessation
- 1974-05-14 DD DD178499A patent/DD111078A5/xx unknown
- 1974-05-14 ES ES426336A patent/ES426336A1/es not_active Expired
- 1974-05-14 NO NO741744A patent/NO140012C/no unknown
- 1974-05-14 SE SE7406452A patent/SE410857B/sv not_active IP Right Cessation
- 1974-05-14 CH CH53477A patent/CH592663A5/xx not_active IP Right Cessation
- 1974-05-14 DK DK263374AA patent/DK136819B/da not_active IP Right Cessation
- 1974-05-14 SU SU7402026597A patent/SU583757A3/ru active
- 1974-05-14 ES ES426335A patent/ES426335A1/es not_active Expired
- 1974-05-15 CS CS743472A patent/CS191881B2/cs unknown
- 1974-05-15 PL PL1974171103A patent/PL90061B1/pl unknown
- 1974-05-15 AT AT400874A patent/AT336030B/de not_active IP Right Cessation
- 1974-05-15 DE DE2423650A patent/DE2423650A1/de not_active Withdrawn
- 1974-05-15 FI FI1498/74A patent/FI55659C/fi active
- 1974-05-15 AR AR253755A patent/AR209421A1/es active
- 1974-05-15 YU YU01336/74A patent/YU133674A/xx unknown
-
1975
- 1975-01-29 AR AR257458A patent/AR210851A1/es active
- 1975-03-18 SU SU752112823A patent/SU589916A3/ru active
-
1981
- 1981-12-08 YU YU02877/81A patent/YU287781A/xx unknown
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