GB1449256A - Cephalosporin derivatives substituted with heterocyclic acyl group - Google Patents
Cephalosporin derivatives substituted with heterocyclic acyl groupInfo
- Publication number
- GB1449256A GB1449256A GB5654473A GB5654473A GB1449256A GB 1449256 A GB1449256 A GB 1449256A GB 5654473 A GB5654473 A GB 5654473A GB 5654473 A GB5654473 A GB 5654473A GB 1449256 A GB1449256 A GB 1449256A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetoxy
- ring
- cephalosporin derivatives
- compound
- acyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1449256 Cephalosporin derivatives YAMANOUCHI PHARMACEUTICAL CO Ltd 6 Dec 1973 [21 Dec 1972 7 March 1973 21 May 1973 9 Aug 1973] 56544/73 Heading C2C Novel compounds IV (in which A is a ring of Formula V, VI or VII W is CH 2 or CO; X is NH, alkylimino, O or S; Y is -CH 2 X, -COX, or -CH=N-; Z is CH or N; R is H, acetoxy, axido or -SP; P is phenyl or a five membered heterocyclic ring containing 2-4 hetero N, O and/or S atoms which ring may be substituted by alkyl, alkylthio, alkylamino, dialkylamino, phenylamino, or acylamino; and R 1 , R 2 and R 3 are H, halo, OH, acylamino, alkylamino, dialkylamino or alkylthio (provided that when A is a ring of Formula VII, R is phenylthio) and non-toxic salts thereof are prepared by reacting a compound I (R<SP>1</SP> is H or acetoxy) with an acid II or a reactive derivative thereof, followed where necessary by reaction of the compound I where R is acetoxy with a compound III (M is H or alkali metal and R<SP>11</SP> is azido or -SP).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12843172A JPS551273B2 (en) | 1972-12-21 | 1972-12-21 | |
| JP2684073A JPS49110686A (en) | 1973-03-07 | 1973-03-07 | |
| JP5644173A JPS504090A (en) | 1973-05-21 | 1973-05-21 | |
| JP8940873A JPS5036487A (en) | 1973-08-09 | 1973-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1449256A true GB1449256A (en) | 1976-09-15 |
Family
ID=27458582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5654473A Expired GB1449256A (en) | 1972-12-21 | 1973-12-06 | Cephalosporin derivatives substituted with heterocyclic acyl group |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | AT328081B (en) |
| CA (1) | CA1022544A (en) |
| DE (1) | DE2362816A1 (en) |
| FR (1) | FR2211214B1 (en) |
| GB (1) | GB1449256A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0049309A1 (en) * | 1980-10-07 | 1982-04-14 | Eisai Co., Ltd. | Cephem derivatives, process for producing thereof, and antibacterial agents comprising said compounds |
| US7569726B2 (en) | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
| US7635715B2 (en) | 2006-12-18 | 2009-12-22 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US7728130B2 (en) | 2005-12-09 | 2010-06-01 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity |
| US8030346B2 (en) | 2007-05-04 | 2011-10-04 | Amgen Inc. | Heterocyclic quinolone derivatives that inhibit prolyl hydroxylase activity |
| US8048894B2 (en) | 2007-04-18 | 2011-11-01 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| US8048892B2 (en) | 2006-12-18 | 2011-11-01 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US8097620B2 (en) | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR208171A1 (en) * | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING NEW DERIVATIVES OF CEF-3-EM-4-CARBOXYL ACID |
| JPS5188988A (en) * | 1975-01-31 | 1976-08-04 | ||
| CA1074784A (en) * | 1974-09-06 | 1980-04-01 | Sumitomo Chemical Company | N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS |
| JPS51115491A (en) * | 1975-04-03 | 1976-10-12 | Sumitomo Chem Co Ltd | Method for preparing 77* *44hydroxyy1*5 naphthyridinee33carboxyamino ** phenylacetamido*cephalosporins |
| ES444346A1 (en) * | 1976-01-15 | 1977-10-01 | Cusi Lab | Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding) |
| US4302454A (en) | 1976-03-03 | 1981-11-24 | Sumitomo Chemical Company, Limited | Cephalosporins |
| US4041162A (en) * | 1976-03-11 | 1977-08-09 | Smithkline Corporation | 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins |
| CH634848A5 (en) * | 1976-08-17 | 1983-02-28 | Fujisawa Pharmaceutical Co | METHOD FOR PRODUCING NEW 7- (N-SUBSTITUTED 2-PHENYLGLYCINAMIDO) -3-SUBSTITUTED-3-CEPHEM-4-CARBONIC ACIDS. |
| EP0003115A1 (en) * | 1978-01-16 | 1979-07-25 | Sandoz Ag | Penicillins, per se and for use as antibacterially active antibiotics and their production |
| GB2045238B (en) * | 1978-11-28 | 1982-12-01 | Mitsui Toatsu Chemicals | Cephalosporins |
| US4468394A (en) * | 1981-04-02 | 1984-08-28 | Eisai Co., Ltd. | Cephalosporin compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL38099A (en) * | 1970-12-17 | 1976-01-30 | Smith Kline French Lab | 3-heterocyclyl thiomethylcephalosporins |
-
1973
- 1973-12-05 CA CA187,391A patent/CA1022544A/en not_active Expired
- 1973-12-06 GB GB5654473A patent/GB1449256A/en not_active Expired
- 1973-12-18 DE DE19732362816 patent/DE2362816A1/en active Pending
- 1973-12-21 FR FR7346044A patent/FR2211214B1/fr not_active Expired
- 1973-12-21 AT AT1075673A patent/AT328081B/en not_active IP Right Cessation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0049309A1 (en) * | 1980-10-07 | 1982-04-14 | Eisai Co., Ltd. | Cephem derivatives, process for producing thereof, and antibacterial agents comprising said compounds |
| US7728130B2 (en) | 2005-12-09 | 2010-06-01 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity |
| US8012968B2 (en) | 2005-12-09 | 2011-09-06 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| US8017626B2 (en) | 2005-12-09 | 2011-09-13 | Amgen Inc. | Quinolone based compounds exhibiting, prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| US7635715B2 (en) | 2006-12-18 | 2009-12-22 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US7928139B2 (en) | 2006-12-18 | 2011-04-19 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US8048892B2 (en) | 2006-12-18 | 2011-11-01 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US7569726B2 (en) | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
| US8048894B2 (en) | 2007-04-18 | 2011-11-01 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| US8349868B2 (en) | 2007-04-18 | 2013-01-08 | Amgen Inc. | Azaquinolones that inhibit prolyl hydroxylase |
| US8030346B2 (en) | 2007-05-04 | 2011-10-04 | Amgen Inc. | Heterocyclic quinolone derivatives that inhibit prolyl hydroxylase activity |
| US8097620B2 (en) | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
Also Published As
| Publication number | Publication date |
|---|---|
| AT328081B (en) | 1976-03-10 |
| DE2362816A1 (en) | 1974-06-27 |
| FR2211214B1 (en) | 1978-01-13 |
| FR2211214A1 (en) | 1974-07-19 |
| CA1022544A (en) | 1977-12-13 |
| ATA1075673A (en) | 1975-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |