FR2229400A1 - 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants - Google Patents

2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants

Info

Publication number
FR2229400A1
FR2229400A1 FR7317516A FR7317516A FR2229400A1 FR 2229400 A1 FR2229400 A1 FR 2229400A1 FR 7317516 A FR7317516 A FR 7317516A FR 7317516 A FR7317516 A FR 7317516A FR 2229400 A1 FR2229400 A1 FR 2229400A1
Authority
FR
France
Prior art keywords
tranquillisers
isoindolin
derivs
naphthyridin
carbonyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7317516A
Other languages
French (fr)
Other versions
FR2229400B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Priority to FR7317516A priority Critical patent/FR2229400A1/en
Priority to OA55189A priority patent/OA04700A/en
Priority to PH15794A priority patent/PH11400A/en
Priority to NL7406194A priority patent/NL7406194A/xx
Priority to HURO780A priority patent/HU169609B/hu
Priority to GB2108174A priority patent/GB1417935A/en
Priority to IE1012/74A priority patent/IE39263B1/en
Priority to AU68880/74A priority patent/AU478373B2/en
Priority to IL44815A priority patent/IL44815A/en
Priority to JP49052378A priority patent/JPS5758345B2/ja
Priority to ZA00743037A priority patent/ZA743037B/en
Priority to CH53477A priority patent/CH592663A5/xx
Priority to MX561874U priority patent/MX4617E/en
Priority to ES426336A priority patent/ES426336A1/en
Priority to NO741744A priority patent/NO140012C/en
Priority to SE7406452A priority patent/SE410857B/en
Priority to ES426335A priority patent/ES426335A1/en
Priority to CA199,810A priority patent/CA1012971A/en
Priority to SU7402026597A priority patent/SU583757A3/en
Priority to BE144308A priority patent/BE815019A/en
Priority to LU70071A priority patent/LU70071A1/xx
Priority to DD178499A priority patent/DD111078A5/xx
Priority to DK263374AA priority patent/DK136819B/en
Priority to CH659574A priority patent/CH592662A5/xx
Priority to AT400874A priority patent/AT336030B/en
Priority to PL1974171103A priority patent/PL90061B1/en
Priority to DE2423650A priority patent/DE2423650A1/en
Priority to YU01336/74A priority patent/YU133674A/en
Priority to CS743472A priority patent/CS191881B2/en
Priority to AR253755A priority patent/AR209421A1/en
Priority to FI1498/74A priority patent/FI55659C/en
Priority to PL18664174A priority patent/PL94204B1/pl
Publication of FR2229400A1 publication Critical patent/FR2229400A1/en
Priority to AR257458A priority patent/AR210851A1/en
Priority to SU752112823A priority patent/SU589916A3/en
Priority to US05/623,359 priority patent/US4016274A/en
Priority to US05/623,358 priority patent/US4038391A/en
Priority to AT86676A priority patent/AT336031B/en
Application granted granted Critical
Publication of FR2229400B1 publication Critical patent/FR2229400B1/fr
Priority to CS766364A priority patent/CS191887B2/en
Priority to YU02877/81A priority patent/YU287781A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cpds. of formula (I) and their acid addition salts are new. (where 1 gp. X is N and the other 3 are CY; each Y is H, halogen, 1-4C alk(ox)yl, CN or NO2; A and A1 are CH or N, such that when A is CH, A1 is CH or N, but when A is N, A1 is N; Z is each H, halogen, 1-4C alk(ox)yl or NO2; either (i) n is zero and R is H, 1-4C (hydroxy)alkyl, 2-4C alkenyl, 2-4C alkynyl or phenyl, or (ii) n is 1 and R is 1-4C (hydroxy)alkyl or phenyl). Prepn. is e.g. by reacting the corresp. cpd. where the piperazinyl gp. is replaced by (substd.) phenyl with the corresp. 1-unsubstd. piperazine.
FR7317516A 1973-05-15 1973-05-15 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants Granted FR2229400A1 (en)

Priority Applications (39)

Application Number Priority Date Filing Date Title
FR7317516A FR2229400A1 (en) 1973-05-15 1973-05-15 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants
OA55189A OA04700A (en) 1973-05-15 1974-04-29 New derivatives of naphthyridine and their preparation process.
PH15794A PH11400A (en) 1973-05-15 1974-04-30 Naphthyridine derivatives and pharmaceutical composition thereof
NL7406194A NL7406194A (en) 1973-05-15 1974-05-08
GB2108174A GB1417935A (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
IE1012/74A IE39263B1 (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
AU68880/74A AU478373B2 (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
IL44815A IL44815A (en) 1973-05-15 1974-05-13 3-(piperazin-1-yl) carbonyloxy (naphthyridin-2-yl) isoindolinones pyrrolo (3,4-b) pyrazines and pyrrolo (3,4-b) pyridines processes for the preparation thereof and pharmaceutical compositions containing the same
JP49052378A JPS5758345B2 (en) 1973-05-15 1974-05-13
ZA00743037A ZA743037B (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
HURO780A HU169609B (en) 1973-05-15 1974-05-13
DD178499A DD111078A5 (en) 1973-05-15 1974-05-14
ES426336A ES426336A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives
NO741744A NO140012C (en) 1973-05-15 1974-05-14 ANALOGICAL PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE DERIVATIVES OF NAFTYRIDINE
SE7406452A SE410857B (en) 1973-05-15 1974-05-14 PROCEDURE FOR THE PREPARATION OF NEW NAFTYRIDINE DERIVATIVES
ES426335A ES426335A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives
CA199,810A CA1012971A (en) 1973-05-15 1974-05-14 Naphtyridine derivatives, method of manufacture and compositions that contain them
SU7402026597A SU583757A3 (en) 1973-05-15 1974-05-14 Method of preparing naphthyridine derivatives or salts thereof
BE144308A BE815019A (en) 1973-05-15 1974-05-14 NEW DERIVATIVES OF NAPHTYRIDINE
LU70071A LU70071A1 (en) 1973-05-15 1974-05-14
CH53477A CH592663A5 (en) 1973-05-15 1974-05-14
DK263374AA DK136819B (en) 1973-05-15 1974-05-14 Analogous process for the preparation of derivatives of naphthyridine or acid addition salts thereof.
CH659574A CH592662A5 (en) 1973-05-15 1974-05-14
MX561874U MX4617E (en) 1973-05-15 1974-05-14 PROCEDURE FOR THE PREPARATION OF NAFTIRIDINE DERIVATIVES
PL1974171103A PL90061B1 (en) 1973-05-15 1974-05-15 Naphthydridine[au6888074a]
AT400874A AT336030B (en) 1973-05-15 1974-05-15 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS
DE2423650A DE2423650A1 (en) 1973-05-15 1974-05-15 NEW NAPHTYRIDE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF
YU01336/74A YU133674A (en) 1973-05-15 1974-05-15 Process for obtaining new naphthiridine derivatives
CS743472A CS191881B2 (en) 1973-05-15 1974-05-15 Method of producing novel derivatives of naphtyridine
AR253755A AR209421A1 (en) 1973-05-15 1974-05-15 PROCEDURE FOR THE PREPARATION OF ISOINDOLINONE-1 AND ITS MONO AND DIAZOTATED (NAPHTHYRIDINE-1.8 IL-2) -6 (PIPERAZINIL) -6 (PIPERAZINIL-1-CARBONYLOXY) RIVATES -1-CARBONYLOXY) -7-OXO 5 PYRROLPYRIDINES AND (NAPHTHYRIDINE1,8 IL-2), 6 (PIPERAZINYL-1 CARBONYLOXY) -7 OXO-5 PYRROLPYRIDINES
FI1498/74A FI55659C (en) 1973-05-15 1974-05-15 FORM OF THERAPEUTIC ACTIVATION OF THERAPEUTIC ACTIVITIES 3- (4-SUBSTITUTES-PIPERAZIN-1-YLCARBONYLOXY) -2- (1,8-NAPHTHYRIDIN-2-YL) ISOINDOLIN-1-ONER
PL18664174A PL94204B1 (en) 1973-05-15 1974-05-15
AR257458A AR210851A1 (en) 1973-05-15 1975-01-29 PROCEDURE TO PREPARE NEW DERIVATIVES OF (NAPHTHYRIDINE-1,8 IL-2) 1 (PIPERAZINIL) -1CARBONYLOXY-3) -2 OXO-5 PYRROLINE
SU752112823A SU589916A3 (en) 1973-05-15 1975-03-18 Method of preparing naphthyridine derivatives or salts thereof
US05/623,359 US4016274A (en) 1973-05-15 1975-10-17 Naphthyridine derivatives
US05/623,358 US4038391A (en) 1973-05-15 1975-10-17 6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines
AT86676A AT336031B (en) 1973-05-15 1976-02-09 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS
CS766364A CS191887B2 (en) 1973-05-15 1976-10-01 Method of producing novel derivatives of naphtyridine
YU02877/81A YU287781A (en) 1973-05-15 1981-12-08 Process for obtaining new naphthiridine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7317516A FR2229400A1 (en) 1973-05-15 1973-05-15 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants

Publications (2)

Publication Number Publication Date
FR2229400A1 true FR2229400A1 (en) 1974-12-13
FR2229400B1 FR2229400B1 (en) 1976-07-16

Family

ID=9119350

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7317516A Granted FR2229400A1 (en) 1973-05-15 1973-05-15 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants

Country Status (3)

Country Link
BE (1) BE815019A (en)
FR (1) FR2229400A1 (en)
ZA (1) ZA743037B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2321290A1 (en) * 1975-04-07 1977-03-18 Rhone Poulenc Ind 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014506603A (en) 2011-02-25 2014-03-17 コンサート ファーマシューティカルズ インコーポレイテッド 2-amino-naphthyridine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2321290A1 (en) * 1975-04-07 1977-03-18 Rhone Poulenc Ind 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Also Published As

Publication number Publication date
ZA743037B (en) 1975-05-28
BE815019A (en) 1974-11-14
FR2229400B1 (en) 1976-07-16

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