FR2321290A1 - 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole - Google Patents

1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Info

Publication number
FR2321290A1
FR2321290A1 FR7510756A FR7510756A FR2321290A1 FR 2321290 A1 FR2321290 A1 FR 2321290A1 FR 7510756 A FR7510756 A FR 7510756A FR 7510756 A FR7510756 A FR 7510756A FR 2321290 A1 FR2321290 A1 FR 2321290A1
Authority
FR
France
Prior art keywords
pyrrolo
substd
tranquillisers
epileptics
hypnotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7510756A
Other languages
French (fr)
Other versions
FR2321290B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7510756A priority Critical patent/FR2321290A1/en
Priority to OA55782A priority patent/OA05287A/en
Priority to NL7603307A priority patent/NL7603307A/en
Priority to CS7600002084A priority patent/CS186734B2/en
Priority to CS7700002623A priority patent/CS186747B2/en
Priority to CS7700002624A priority patent/CS186748B2/en
Priority to PH18289A priority patent/PH14015A/en
Priority to AU12674/76A priority patent/AU496349B2/en
Priority to US05/673,868 priority patent/US4086348A/en
Priority to DD192209A priority patent/DD123605A5/xx
Priority to ZA762018A priority patent/ZA762018B/en
Priority to CY1085A priority patent/CY1085A/en
Priority to IL49344A priority patent/IL49344A/en
Priority to JP51038103A priority patent/JPS51122094A/en
Priority to IE704/76A priority patent/IE42973B1/en
Priority to CA249,577A priority patent/CA1072957A/en
Priority to GB13703/76A priority patent/GB1483996A/en
Priority to YU00869/76A priority patent/YU86976A/en
Priority to DK162976A priority patent/DK162976A/en
Priority to CH430576A priority patent/CH613453A5/xx
Priority to CH1212178A priority patent/CH614209A5/en
Priority to SE7604044D priority patent/SE7604044L/en
Priority to LU74703A priority patent/LU74703A1/xx
Priority to SE7604044A priority patent/SE421793B/en
Priority to MX14476U priority patent/MX3138E/en
Priority to SU762339152A priority patent/SU648102A3/en
Priority to BE165879A priority patent/BE840428A/en
Priority to NO761168A priority patent/NO144019C/en
Priority to PT64976A priority patent/PT64976B/en
Priority to PL1976202791A priority patent/PL100987B1/en
Priority to PL1976202792A priority patent/PL100988B1/en
Priority to DE19762615067 priority patent/DE2615067A1/en
Priority to PL1976188560A priority patent/PL100184B1/en
Priority to AR262814A priority patent/AR214286A1/en
Priority to FI760937A priority patent/FI60012C/en
Priority to ES446762A priority patent/ES446762A1/en
Priority to HU76RO886A priority patent/HU176315B/en
Priority to AT249776A priority patent/AT348524B/en
Priority to ES448847A priority patent/ES448847A1/en
Priority to AR264893A priority patent/AR213739A1/en
Priority to AR264924A priority patent/AR214055A1/en
Publication of FR2321290A1 publication Critical patent/FR2321290A1/en
Priority to SU772473623A priority patent/SU638258A3/en
Priority to SU772473622A priority patent/SU637082A3/en
Priority to US05/843,369 priority patent/US4131674A/en
Priority to AT204878A priority patent/AT348529B/en
Priority to AT204778A priority patent/AT348528B/en
Application granted granted Critical
Publication of FR2321290B1 publication Critical patent/FR2321290B1/fr
Priority to HK545/80A priority patent/HK54580A/en
Priority to YU01304/82A priority patent/YU130482A/en
Priority to YU01305/82A priority patent/YU130582A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New 1,8-naphthyridine derivs. of formula (I) and their acid addition salts are novel cpds. (where X1 and X2 ar together with the pyrro -lidine ring are isoindoline (opt. substd. by 1 or 2 halo, 1-4C alkyl, 1-4C alkoxy, nitro or CF3 groups), 6,7-dihydro-5H-pyrrolo (3,4-b) pyrazine, 6,7-dihydro-5H-pyrrolo (3,4-b) pyridine or 2,3,6,7-tetrahydro-5H-oxathiinno (1,4) (2,3-c)pyrrole; Y are same or different groups chosen from H, halo, 1-4C alkyl, 1-4C alkoxy and cyano and R1,R2 are same or different H, 1-12C alkyl (opt. substd. by hydroxy, 1-4C alkoxy, phenyl; amino, mono- or di 1-4C alkylamino, a 5-6 membered N-heterocyclyl or 2-5c alkoxycarbonyl), 3-4C alkenyl, 3-4C alkynyl, 3-6C cycloalkyl or together with the N atom form a 5-6 membered heterocyclic opt. contg. an O or S atom). are tranquillisers, hypnotics, anticonvulsants, anti-epileptics and muscle relaxants.
FR7510756A 1975-04-07 1975-04-07 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole Granted FR2321290A1 (en)

Priority Applications (49)

Application Number Priority Date Filing Date Title
FR7510756A FR2321290A1 (en) 1975-04-07 1975-04-07 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole
OA55782A OA05287A (en) 1975-04-07 1976-03-26 New heterocyclic compounds and their preparation.
NL7603307A NL7603307A (en) 1975-04-07 1976-03-30 NEW HETEROCYCLICAL COMPOUNDS, THEIR PREPARATION AND PREPARATIONS CONTAINING THESE COMPOUNDS.
CS7600002084A CS186734B2 (en) 1975-04-07 1976-03-31 Method of producing derivatives of iso-indoline
CS7700002623A CS186747B2 (en) 1975-04-07 1976-03-31 Method of producing novel derivatives of iso-indoline
CS7700002624A CS186748B2 (en) 1975-04-07 1976-03-31 Method of producing novel derivatives of iso-indoline
PH18289A PH14015A (en) 1975-04-07 1976-04-05 Naphthyridinylisoindolinones and pharmaceucal compositions containing them
AU12674/76A AU496349B2 (en) 1976-04-05 1, 8-naphthyridine derivatives
US05/673,868 US4086348A (en) 1975-04-07 1976-04-05 Naphthyridine derivatives
DD192209A DD123605A5 (en) 1975-04-07 1976-04-05
ZA762018A ZA762018B (en) 1975-04-07 1976-04-05 Heterocyclic compounds
CY1085A CY1085A (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
IL49344A IL49344A (en) 1975-04-07 1976-04-05 2-substituted-7-halo-1,8-maphthyridine compounds,processesfor preparing the same and pharmaceutical compositions containing the same
JP51038103A JPS51122094A (en) 1975-04-07 1976-04-05 Production of heterocyclic compound
IE704/76A IE42973B1 (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
CA249,577A CA1072957A (en) 1975-04-07 1976-04-05 Composition and preparation of heterocyclic compounds
GB13703/76A GB1483996A (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
YU00869/76A YU86976A (en) 1975-04-07 1976-04-06 Process for obtaining new heterocyclic compounds
DK162976A DK162976A (en) 1975-04-07 1976-04-06 PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC COMPOUNDS
CH430576A CH613453A5 (en) 1975-04-07 1976-04-06
CH1212178A CH614209A5 (en) 1975-04-07 1976-04-06 Process for the preparation of new heterocyclic compounds
SE7604044D SE7604044L (en) 1975-04-07 1976-04-06 PROCEDURE FOR PREPARING NEW HETEROCYCLIC ASSOCIATIONS
LU74703A LU74703A1 (en) 1975-04-07 1976-04-06
SE7604044A SE421793B (en) 1975-04-07 1976-04-06 ANALOGY PROCEDURE FOR THE PREPARATION OF NAFTYRIDINE-SUBSTITUTED PYRROLLER DERIVATIVES
MX14476U MX3138E (en) 1975-04-07 1976-04-06 PROCEDURE FOR THE PREPARATION OF HETERO CYCLIC COMPOUNDS
SU762339152A SU648102A3 (en) 1975-04-07 1976-04-06 Method of obtaining naphthyhyridine or derivatives or salts thereof
BE165879A BE840428A (en) 1975-04-07 1976-04-06 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
NO761168A NO144019C (en) 1975-04-07 1976-04-06 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE NAPHYRIDE INGREDIATES
PT64976A PT64976B (en) 1975-04-07 1976-04-06 NOVEL HETEROCYCLIC COMPOUNDS THEIR PREPARATION AND THE COMPOSITIONS CONTAINING SAME
PL1976202791A PL100987B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
PL1976202792A PL100988B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
DE19762615067 DE2615067A1 (en) 1975-04-07 1976-04-07 NEW HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND COMPOSITIONS THEREOF
PL1976188560A PL100184B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
AR262814A AR214286A1 (en) 1975-04-07 1976-04-07 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 7-CHLORINE- (NAPHTHYRIDINE-1.8 IL-2) 1 OXO 2-AMINOCARBONYLOXY-5 PYRROLINE
FI760937A FI60012C (en) 1975-04-07 1976-04-07 FORM OF THERAPEUTIC ACTIVATION OF 2- (7-CHLORO-1,8-NAPHTHYRIDIN-2-YL) -3- (CARBAMOYLOXY) ISOINDOLIN-1-ONER
ES446762A ES446762A1 (en) 1975-04-07 1976-04-07 Naphthyridine derivatives
HU76RO886A HU176315B (en) 1975-04-07 1976-04-07 Process for producing substituted aminocarbonyloxy-isoindolinone-, -pyrrolo-pyridine-, pyrrolo-pyrasine and oxathiino-pyrrole derivatives
AT249776A AT348524B (en) 1975-04-07 1976-04-07 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITION SALT
ES448847A ES448847A1 (en) 1975-04-07 1976-06-14 Naphthyridine derivatives
AR264893A AR213739A1 (en) 1975-04-07 1976-09-28 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF (NAPHTHYRIDINE-1,8 IL-2) -1 OXO-2 AMINOCARBONYLOXY-5 PYRROLINE
AR264924A AR214055A1 (en) 1975-04-07 1976-09-30 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 7-CHLORINE (NAPHTHYRIDINE-1.8 IL-2) -1 OXO-2 AMINOCARBONYLOXY-5 PYRROLINE
SU772473623A SU638258A3 (en) 1975-04-07 1977-04-21 Method of obtaining derivatives of naphthyridine
SU772473622A SU637082A3 (en) 1975-04-07 1977-04-21 Method of obtaining naphthyridine derivatives
US05/843,369 US4131674A (en) 1975-04-07 1977-10-19 Naphtyridine derivatives
AT204878A AT348529B (en) 1975-04-07 1978-03-22 PROCESS FOR THE PRODUCTION OF NEW NAPHTHYRIDE DERIVATIVES
AT204778A AT348528B (en) 1975-04-07 1978-03-22 PROCESS FOR THE PRODUCTION OF NEW NAPHTHYRIDE DERIVATIVES
HK545/80A HK54580A (en) 1975-04-07 1980-09-25 1,8-naphthyridine derivatives
YU01304/82A YU130482A (en) 1975-04-07 1982-06-15 Process for obtaining new heterocyclic compounds
YU01305/82A YU130582A (en) 1975-04-07 1982-06-15 Process for obtaining new heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7510756A FR2321290A1 (en) 1975-04-07 1975-04-07 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Publications (2)

Publication Number Publication Date
FR2321290A1 true FR2321290A1 (en) 1977-03-18
FR2321290B1 FR2321290B1 (en) 1978-08-04

Family

ID=9153590

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7510756A Granted FR2321290A1 (en) 1975-04-07 1975-04-07 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Country Status (3)

Country Link
BE (1) BE840428A (en)
FR (1) FR2321290A1 (en)
ZA (1) ZA762018B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522970A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for the preparation of optical isomers of a 2-aminonaphthyridine derivative
EP0522969A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. 2-Aminonaphthyridine, its preparation and use
EP0522972A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for preparation of a dextrorotatory isomer of an isoindolinone derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2117740A1 (en) * 1970-12-14 1972-07-28 Rhone Poulenc Sa
FR2229400A1 (en) * 1973-05-15 1974-12-13 Rhone Poulenc Sa 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2117740A1 (en) * 1970-12-14 1972-07-28 Rhone Poulenc Sa
FR2229400A1 (en) * 1973-05-15 1974-12-13 Rhone Poulenc Sa 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522970A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for the preparation of optical isomers of a 2-aminonaphthyridine derivative
EP0522969A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. 2-Aminonaphthyridine, its preparation and use
EP0522972A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for preparation of a dextrorotatory isomer of an isoindolinone derivative
FR2678934A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF THE DEXTROGYE ISOMER OF AN ISOINDOLINONE DERIVATIVE
FR2678932A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF OPTICAL ISOMERS OF AN AMINO-2-NAPHTHYRIDINE DERIVATIVE
FR2678931A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa NEW AMINO-2 NAPHTHYRIDINE DERIVATIVE, ITS PREPARATION AND ITS USE.
WO1993001187A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Process for the preparation of a dextrogyral isomer of an isoindolinone derivative
WO1993001189A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Method for preparating optical isomers of a 2-amino naphthyridine derivative
WO1993001190A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Novel 2-amino naphthyridine derivative, its preparation and use

Also Published As

Publication number Publication date
BE840428A (en) 1976-10-06
FR2321290B1 (en) 1978-08-04
ZA762018B (en) 1977-04-27

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