FR2340731A1 - 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole - Google Patents

1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Info

Publication number
FR2340731A1
FR2340731A1 FR7603774A FR7603774A FR2340731A1 FR 2340731 A1 FR2340731 A1 FR 2340731A1 FR 7603774 A FR7603774 A FR 7603774A FR 7603774 A FR7603774 A FR 7603774A FR 2340731 A1 FR2340731 A1 FR 2340731A1
Authority
FR
France
Prior art keywords
pyrrolo
substd
tranquillisers
epileptics
hypnotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7603774A
Other languages
French (fr)
Other versions
FR2340731B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7603774A priority Critical patent/FR2340731A1/en
Priority to OA55782A priority patent/OA05287A/en
Priority to NL7603307A priority patent/NL7603307A/en
Priority to CS7600002084A priority patent/CS186734B2/en
Priority to CS7700002623A priority patent/CS186747B2/en
Priority to CS7700002624A priority patent/CS186748B2/en
Priority to US05/673,868 priority patent/US4086348A/en
Priority to CA249,577A priority patent/CA1072957A/en
Priority to JP51038103A priority patent/JPS51122094A/en
Priority to DD192209A priority patent/DD123605A5/xx
Priority to IL49344A priority patent/IL49344A/en
Priority to PH18289A priority patent/PH14015A/en
Priority to CY1085A priority patent/CY1085A/en
Priority to GB13703/76A priority patent/GB1483996A/en
Priority to AU12674/76A priority patent/AU496349B2/en
Priority to IE704/76A priority patent/IE42973B1/en
Priority to PT64976A priority patent/PT64976B/en
Priority to SE7604044A priority patent/SE421793B/en
Priority to DK162976A priority patent/DK162976A/en
Priority to MX14476U priority patent/MX3138E/en
Priority to YU00869/76A priority patent/YU86976A/en
Priority to SU762339152A priority patent/SU648102A3/en
Priority to CH1212178A priority patent/CH614209A5/en
Priority to NO761168A priority patent/NO144019C/en
Priority to SE7604044D priority patent/SE7604044L/en
Priority to LU74703A priority patent/LU74703A1/xx
Priority to CH430576A priority patent/CH613453A5/xx
Priority to HU76RO886A priority patent/HU176315B/en
Priority to FI760937A priority patent/FI60012C/en
Priority to DE19762615067 priority patent/DE2615067A1/en
Priority to ES446762A priority patent/ES446762A1/en
Priority to AR262814A priority patent/AR214286A1/en
Priority to PL1976202791A priority patent/PL100987B1/en
Priority to PL1976188560A priority patent/PL100184B1/en
Priority to PL1976202792A priority patent/PL100988B1/en
Priority to AT249776A priority patent/AT348524B/en
Priority to ES448848A priority patent/ES448848A1/en
Priority to ES448847A priority patent/ES448847A1/en
Priority to AR264893A priority patent/AR213739A1/en
Priority to AR264924A priority patent/AR214055A1/en
Priority to SU772473623A priority patent/SU638258A3/en
Priority to SU772473622A priority patent/SU637082A3/en
Publication of FR2340731A1 publication Critical patent/FR2340731A1/en
Priority to US05/843,369 priority patent/US4131674A/en
Priority to AT204878A priority patent/AT348529B/en
Priority to AT204778A priority patent/AT348528B/en
Application granted granted Critical
Publication of FR2340731B1 publication Critical patent/FR2340731B1/fr
Priority to HK545/80A priority patent/HK54580A/en
Priority to JP4923581A priority patent/JPS56156276A/en
Priority to FI811276A priority patent/FI63589C/en
Priority to YU01304/82A priority patent/YU130482A/en
Priority to YU01305/82A priority patent/YU130582A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

New 1,8-naphthyridine derivs. of formula (I) and their acid addition salts are novel cpds. (where X1 and X2 ar together with the pyrro -lidine ring are isoindoline (opt. substd. by 1 or 2 halo, 1-4C alkyl, 1-4C alkoxy, nitro or CF3 groups), 6,7-dihydro-5H-pyrrolo (3,4-b) pyrazine, 6,7-dihydro-5H-pyrrolo (3,4-b) pyridine or 2,3,6,7-tetrahydro-5H-oxathiinno (1,4) (2,3-c)pyrrole; Y are same or different groups chosen from H, halo, 1-4C alkyl, 1-4C alkoxy and cyano and R1,R2 are same or different H, 1-12C alkyl (opt. substd. by hydroxy, 1-4C alkoxy, phenyl; amino, mono- or di 1-4C alkylamino, a 5-6 membered N-heterocyclyl or 2-5c alkoxycarbonyl), 3-4C alkenyl, 3-4C alkynyl, 3-6C cycloalkyl or together with the N atom form a 5-6 membered heterocyclic opt. contg. an O or S atom). are tranquillisers, hypnotics, anticonvulsants, anti-epileptics and muscle relaxants.
FR7603774A 1975-04-07 1976-02-11 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole Granted FR2340731A1 (en)

Priority Applications (50)

Application Number Priority Date Filing Date Title
FR7603774A FR2340731A1 (en) 1976-02-11 1976-02-11 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole
OA55782A OA05287A (en) 1975-04-07 1976-03-26 New heterocyclic compounds and their preparation.
NL7603307A NL7603307A (en) 1975-04-07 1976-03-30 NEW HETEROCYCLICAL COMPOUNDS, THEIR PREPARATION AND PREPARATIONS CONTAINING THESE COMPOUNDS.
CS7600002084A CS186734B2 (en) 1975-04-07 1976-03-31 Method of producing derivatives of iso-indoline
CS7700002623A CS186747B2 (en) 1975-04-07 1976-03-31 Method of producing novel derivatives of iso-indoline
CS7700002624A CS186748B2 (en) 1975-04-07 1976-03-31 Method of producing novel derivatives of iso-indoline
US05/673,868 US4086348A (en) 1975-04-07 1976-04-05 Naphthyridine derivatives
CA249,577A CA1072957A (en) 1975-04-07 1976-04-05 Composition and preparation of heterocyclic compounds
JP51038103A JPS51122094A (en) 1975-04-07 1976-04-05 Production of heterocyclic compound
DD192209A DD123605A5 (en) 1975-04-07 1976-04-05
IL49344A IL49344A (en) 1975-04-07 1976-04-05 2-substituted-7-halo-1,8-maphthyridine compounds,processesfor preparing the same and pharmaceutical compositions containing the same
PH18289A PH14015A (en) 1975-04-07 1976-04-05 Naphthyridinylisoindolinones and pharmaceucal compositions containing them
CY1085A CY1085A (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
GB13703/76A GB1483996A (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
AU12674/76A AU496349B2 (en) 1976-04-05 1, 8-naphthyridine derivatives
IE704/76A IE42973B1 (en) 1975-04-07 1976-04-05 1,8-naphthyridine derivatives
PT64976A PT64976B (en) 1975-04-07 1976-04-06 NOVEL HETEROCYCLIC COMPOUNDS THEIR PREPARATION AND THE COMPOSITIONS CONTAINING SAME
SE7604044A SE421793B (en) 1975-04-07 1976-04-06 ANALOGY PROCEDURE FOR THE PREPARATION OF NAFTYRIDINE-SUBSTITUTED PYRROLLER DERIVATIVES
DK162976A DK162976A (en) 1975-04-07 1976-04-06 PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC COMPOUNDS
MX14476U MX3138E (en) 1975-04-07 1976-04-06 PROCEDURE FOR THE PREPARATION OF HETERO CYCLIC COMPOUNDS
YU00869/76A YU86976A (en) 1975-04-07 1976-04-06 Process for obtaining new heterocyclic compounds
SU762339152A SU648102A3 (en) 1975-04-07 1976-04-06 Method of obtaining naphthyhyridine or derivatives or salts thereof
CH1212178A CH614209A5 (en) 1975-04-07 1976-04-06 Process for the preparation of new heterocyclic compounds
NO761168A NO144019C (en) 1975-04-07 1976-04-06 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE NAPHYRIDE INGREDIATES
SE7604044D SE7604044L (en) 1975-04-07 1976-04-06 PROCEDURE FOR PREPARING NEW HETEROCYCLIC ASSOCIATIONS
LU74703A LU74703A1 (en) 1975-04-07 1976-04-06
CH430576A CH613453A5 (en) 1975-04-07 1976-04-06
HU76RO886A HU176315B (en) 1975-04-07 1976-04-07 Process for producing substituted aminocarbonyloxy-isoindolinone-, -pyrrolo-pyridine-, pyrrolo-pyrasine and oxathiino-pyrrole derivatives
FI760937A FI60012C (en) 1975-04-07 1976-04-07 FORM OF THERAPEUTIC ACTIVATION OF 2- (7-CHLORO-1,8-NAPHTHYRIDIN-2-YL) -3- (CARBAMOYLOXY) ISOINDOLIN-1-ONER
DE19762615067 DE2615067A1 (en) 1975-04-07 1976-04-07 NEW HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND COMPOSITIONS THEREOF
ES446762A ES446762A1 (en) 1975-04-07 1976-04-07 Naphthyridine derivatives
AR262814A AR214286A1 (en) 1975-04-07 1976-04-07 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 7-CHLORINE- (NAPHTHYRIDINE-1.8 IL-2) 1 OXO 2-AMINOCARBONYLOXY-5 PYRROLINE
PL1976202791A PL100987B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
PL1976188560A PL100184B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
PL1976202792A PL100988B1 (en) 1975-04-07 1976-04-07 METHOD OF MAKING NEW DERIVATIVES OF NAPHTHRIDINYL-PIROLINE
AT249776A AT348524B (en) 1975-04-07 1976-04-07 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITION SALT
ES448848A ES448848A1 (en) 1975-04-07 1976-06-14 Procedure for preparation of a heterociclic compound. (Machine-translation by Google Translate, not legally binding)
ES448847A ES448847A1 (en) 1975-04-07 1976-06-14 Naphthyridine derivatives
AR264893A AR213739A1 (en) 1975-04-07 1976-09-28 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF (NAPHTHYRIDINE-1,8 IL-2) -1 OXO-2 AMINOCARBONYLOXY-5 PYRROLINE
AR264924A AR214055A1 (en) 1975-04-07 1976-09-30 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 7-CHLORINE (NAPHTHYRIDINE-1.8 IL-2) -1 OXO-2 AMINOCARBONYLOXY-5 PYRROLINE
SU772473623A SU638258A3 (en) 1975-04-07 1977-04-21 Method of obtaining derivatives of naphthyridine
SU772473622A SU637082A3 (en) 1975-04-07 1977-04-21 Method of obtaining naphthyridine derivatives
US05/843,369 US4131674A (en) 1975-04-07 1977-10-19 Naphtyridine derivatives
AT204878A AT348529B (en) 1975-04-07 1978-03-22 PROCESS FOR THE PRODUCTION OF NEW NAPHTHYRIDE DERIVATIVES
AT204778A AT348528B (en) 1975-04-07 1978-03-22 PROCESS FOR THE PRODUCTION OF NEW NAPHTHYRIDE DERIVATIVES
HK545/80A HK54580A (en) 1975-04-07 1980-09-25 1,8-naphthyridine derivatives
JP4923581A JPS56156276A (en) 1976-02-11 1981-04-01 Heterocyclic compound
FI811276A FI63589C (en) 1976-02-11 1981-04-23 FORM OF THERAPEUTIC ACTIVATION OF 6- (7-CHLORO-1,8-NAPHTHYRIDIN-2-YL) -5-CARBAMOYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRROLO (3,4-B) PYRAZINER
YU01304/82A YU130482A (en) 1975-04-07 1982-06-15 Process for obtaining new heterocyclic compounds
YU01305/82A YU130582A (en) 1975-04-07 1982-06-15 Process for obtaining new heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7603774A FR2340731A1 (en) 1976-02-11 1976-02-11 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Publications (2)

Publication Number Publication Date
FR2340731A1 true FR2340731A1 (en) 1977-09-09
FR2340731B1 FR2340731B1 (en) 1979-10-05

Family

ID=9168999

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7603774A Granted FR2340731A1 (en) 1975-04-07 1976-02-11 1,8-naphthyridine tranquillisers, e hypnotics, anti-epileptics etc. - 2-substd. by isoindoline, pyrrolo-(3,4-b)-pyrazines, pyrrolo-(3,4-b)-pyridine or oxathino-(1,4)(2,3-c)-pyrrole

Country Status (2)

Country Link
JP (1) JPS56156276A (en)
FR (1) FR2340731A1 (en)

Also Published As

Publication number Publication date
JPS56156276A (en) 1981-12-02
JPS6116398B2 (en) 1986-04-30
FR2340731B1 (en) 1979-10-05

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