ATE76074T1 - 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4-DIHYDRO-4-OXO 3-QUINOLINECARBONIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM. - Google Patents

7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4-DIHYDRO-4-OXO 3-QUINOLINECARBONIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM.

Info

Publication number
ATE76074T1
ATE76074T1 AT86102769T AT86102769T ATE76074T1 AT E76074 T1 ATE76074 T1 AT E76074T1 AT 86102769 T AT86102769 T AT 86102769T AT 86102769 T AT86102769 T AT 86102769T AT E76074 T1 ATE76074 T1 AT E76074T1
Authority
AT
Austria
Prior art keywords
dihydro
oxo
amino
cyclopropyl
acids
Prior art date
Application number
AT86102769T
Other languages
German (de)
Inventor
Michael Dr Schriewer
Klaus Dr Grohe
Hans-Joachim Dr Zeiler
Karl Georg Dr Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE76074T1 publication Critical patent/ATE76074T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Quinoline Compounds (AREA)

Abstract

Novel antibacterially active 7-amino-1-(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the formula <IMAGE> in which X1 and X2 can be identical or different and represent hydrogen or halogen, R1, R2 and R3 represent hydrogen, methyl, chlorine or fluorine, the radicals R1-R3 never all being identical, and R4 and R5, together with the nitrogen atom to which they are bonded, form a 5-membered or 6-membered heterocyclic ring which may be substituted.
AT86102769T 1985-03-16 1986-03-03 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4-DIHYDRO-4-OXO 3-QUINOLINECARBONIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM. ATE76074T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853509546 DE3509546A1 (en) 1985-03-16 1985-03-16 7-AMINO-1- (SUBST.CYCLOPROPYL) -1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
EP86102769A EP0198192B1 (en) 1985-03-16 1986-03-03 7-amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them

Publications (1)

Publication Number Publication Date
ATE76074T1 true ATE76074T1 (en) 1992-05-15

Family

ID=6265442

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86102769T ATE76074T1 (en) 1985-03-16 1986-03-03 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4-DIHYDRO-4-OXO 3-QUINOLINECARBONIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM.

Country Status (5)

Country Link
US (1) US4705788A (en)
EP (2) EP0198192B1 (en)
JP (2) JPS61218575A (en)
AT (1) ATE76074T1 (en)
DE (2) DE3509546A1 (en)

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EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
DE3685157D1 (en) * 1985-06-26 1992-06-11 Daiichi Seiyaku Co PYRIDON CARBON ACID DERIVATIVES.
DE3608745A1 (en) * 1985-07-24 1987-01-29 Bayer Ag BACTERICIDAL PREPARATIONS FOR APPLICATION IN THE VETERINE MEDICINE AREA
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives
DE3611196A1 (en) * 1986-04-04 1987-10-15 Bayer Ag CYOLOPROPYLAMINE CONTAINING TRIFLUORMETHYL GROUPS
US4965273A (en) * 1986-10-08 1990-10-23 Bristol-Myers Company Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
NZ222047A (en) * 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
ZA877471B (en) * 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
DE3702393A1 (en) * 1987-01-28 1988-08-11 Bayer Ag 8-CYANO-1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO- 3-CHINOLINE CARBONIC ACIDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
SI8712447A8 (en) * 1987-12-31 1995-12-31 Krka Tovarna Zdravil Process for preparing 1-substituted 6-fluoro-4-oxo-7-(1-piperazinyl) -1,4-dihydroquinoline-3-carboxylic acid and new intermediate used in this process
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JPH0674261B2 (en) * 1988-06-21 1994-09-21 塩野義製薬株式会社 Quinolonecarboxylic acid derivative
DE3824432A1 (en) * 1988-07-19 1990-03-22 Bayer Ag 2,2-DIFLUORCYCLOPROPYL DERIVATIVES
US5208388A (en) * 1988-07-19 1993-05-04 Bayer Aktiengesellschaft 2,2-difluorocyclopropyl derivatives
DE3824433A1 (en) * 1988-07-19 1990-01-25 Bayer Ag, 5090 Leverkusen FLUORCYCLOPROPYL DERIVATIVES
US5264632A (en) * 1988-07-19 1993-11-23 Bayer Aktiengesellschaft 2,2-difluorocyclopropyl derivatives
JP2777661B2 (en) * 1988-10-20 1998-07-23 大塚製薬株式会社 Benzoheterocyclic compounds
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
DE69231422T2 (en) * 1991-05-28 2001-03-29 Daiichi Pharmaceutical Co., Ltd. PYRIDONE CARBONIC ACID DERIVATIVES
US5330992A (en) * 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
NO301165B1 (en) * 1992-12-25 1997-09-22 Daiichi Seiyaku Co Bicyclic amine derivatives and antibacterial agents containing them
US5356903A (en) * 1993-04-22 1994-10-18 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolines
HUT67395A (en) * 1993-07-13 1995-04-28 Somfai Method for the n-cyclopropylation of primary and secondary aromatic amines
US5668147A (en) * 1993-10-28 1997-09-16 Kaken Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivatives and salts thereof
AU683569B2 (en) * 1994-07-18 1997-11-13 Sankyo Company Limited Trifluoromethylquinolinecarboxylic acid derivative
IN186245B (en) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US6552217B2 (en) 2000-08-01 2003-04-22 Eastman Chemical Company Process for the preparation of alkyl 1-methylcyclopropanecarboxylate

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FR1349124A (en) * 1961-08-23 1964-01-17 Smith Kline French Lab Process for the preparation of cyclopropyl amines
GB1331706A (en) * 1971-04-23 1973-09-26 Shell Int Research Cyclopropane derivatives and biologicall active compositions thereof
JPS581742B2 (en) * 1973-05-30 1983-01-12 株式会社日立製作所 Bunko Koudokei
GB1599907A (en) * 1977-04-26 1981-10-07 Glaxo Lab Ltd Isoindolines
JPS5845426B2 (en) * 1978-09-29 1983-10-08 杏林製薬株式会社 Substituted quinoline carboxylic acid derivatives
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3142854A1 (en) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
AU537813B2 (en) * 1981-02-10 1984-07-12 Kyorin Seiyaku K.K. Quinoline carboxylic acid derivatives
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
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DE3248506A1 (en) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7 (ALKYL-1-PIPERAZINYL) -3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
DE3248507A1 (en) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen MICROBICIDE AGENTS BASED ON CHINOLONIC CARBONIC ACID
DE3306771A1 (en) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3318145A1 (en) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
DE3420770A1 (en) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (3-OXO-1-PIPERAZINYL) -3-CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
JPS61176557A (en) * 1985-01-31 1986-08-08 Sumitomo Chem Co Ltd Optically active 2,2-dimethylcyclopropylamine and production thereof
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives

Also Published As

Publication number Publication date
EP0198192B1 (en) 1992-05-13
JPH05213836A (en) 1993-08-24
EP0300155A2 (en) 1989-01-25
JPH0560827B2 (en) 1993-09-03
DE3685248D1 (en) 1992-06-17
EP0300155A3 (en) 1990-01-17
JPS61218575A (en) 1986-09-29
US4705788A (en) 1987-11-10
DE3509546A1 (en) 1986-09-25
EP0198192A1 (en) 1986-10-22
JP2504895B2 (en) 1996-06-05

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