EP0300155A3 - Cyclopropyl amines - Google Patents
Cyclopropyl amines Download PDFInfo
- Publication number
- EP0300155A3 EP0300155A3 EP88107985A EP88107985A EP0300155A3 EP 0300155 A3 EP0300155 A3 EP 0300155A3 EP 88107985 A EP88107985 A EP 88107985A EP 88107985 A EP88107985 A EP 88107985A EP 0300155 A3 EP0300155 A3 EP 0300155A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- cyclopropyl
- cyclopropyl amines
- amines
- production
- loncarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 Cyclopropyl amines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical class NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Quinoline Compounds (AREA)
Abstract
Die Erfindung betrifft Cyclopropylamine, Zwischenprodukte zu deren Herstellung, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von 1-Cyclopropyl-chino loncarbonsäuren. The invention relates to cyclopropylamines, intermediates for their production, processes for their production and their use for the preparation of 1-cyclopropyl-quino loncarboxylic acids.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3509546 | 1985-03-16 | ||
DE19853509546 DE3509546A1 (en) | 1985-03-16 | 1985-03-16 | 7-AMINO-1- (SUBST.CYCLOPROPYL) -1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86102769A Division EP0198192B1 (en) | 1985-03-16 | 1986-03-03 | 7-amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them |
EP86102769.6 Division | 1986-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0300155A2 EP0300155A2 (en) | 1989-01-25 |
EP0300155A3 true EP0300155A3 (en) | 1990-01-17 |
Family
ID=6265442
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86102769A Expired - Lifetime EP0198192B1 (en) | 1985-03-16 | 1986-03-03 | 7-amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them |
EP88107985A Withdrawn EP0300155A3 (en) | 1985-03-16 | 1986-03-03 | Cyclopropyl amines |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86102769A Expired - Lifetime EP0198192B1 (en) | 1985-03-16 | 1986-03-03 | 7-amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them |
Country Status (5)
Country | Link |
---|---|
US (1) | US4705788A (en) |
EP (2) | EP0198192B1 (en) |
JP (2) | JPS61218575A (en) |
AT (1) | ATE76074T1 (en) |
DE (2) | DE3509546A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6212760A (en) * | 1984-12-14 | 1987-01-21 | Dai Ichi Seiyaku Co Ltd | 1-(2-halogenocyclopropyl)quinolinecarboxylic acid derivative |
ATE75740T1 (en) * | 1985-06-26 | 1992-05-15 | Daiichi Seiyaku Co | PYRIDONECARBONIC ACID DERIVATIVES. |
DE3608745A1 (en) * | 1985-07-24 | 1987-01-29 | Bayer Ag | BACTERICIDAL PREPARATIONS FOR APPLICATION IN THE VETERINE MEDICINE AREA |
DE3705621C2 (en) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclic substituted quinolonecarboxylic acid derivatives |
DE3611196A1 (en) * | 1986-04-04 | 1987-10-15 | Bayer Ag | CYOLOPROPYLAMINE CONTAINING TRIFLUORMETHYL GROUPS |
NZ222047A (en) * | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
US4965273A (en) * | 1986-10-08 | 1990-10-23 | Bristol-Myers Company | Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents |
ZA877471B (en) * | 1986-10-08 | 1988-04-05 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents |
DE3702393A1 (en) * | 1987-01-28 | 1988-08-11 | Bayer Ag | 8-CYANO-1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO- 3-CHINOLINE CARBONIC ACIDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM |
US4889857A (en) * | 1987-10-12 | 1989-12-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Quinolonecarboxylic acid compounds and pharmaceutical use thereof |
YU46099B (en) * | 1987-12-31 | 1992-12-21 | Krka Tovarna Zdravil | PROCESS FOR PREPARING 1-SUBSTITUTED 6-FLUORO-4-OXO-7- 1-PIPERAZINYL) -1 |
IL90062A (en) * | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them |
JPH0674261B2 (en) * | 1988-06-21 | 1994-09-21 | 塩野義製薬株式会社 | Quinolonecarboxylic acid derivative |
DE3824432A1 (en) * | 1988-07-19 | 1990-03-22 | Bayer Ag | 2,2-DIFLUORCYCLOPROPYL DERIVATIVES |
US5208388A (en) * | 1988-07-19 | 1993-05-04 | Bayer Aktiengesellschaft | 2,2-difluorocyclopropyl derivatives |
US5264632A (en) * | 1988-07-19 | 1993-11-23 | Bayer Aktiengesellschaft | 2,2-difluorocyclopropyl derivatives |
DE3824433A1 (en) * | 1988-07-19 | 1990-01-25 | Bayer Ag, 5090 Leverkusen | FLUORCYCLOPROPYL DERIVATIVES |
JP2777661B2 (en) * | 1988-10-20 | 1998-07-23 | 大塚製薬株式会社 | Benzoheterocyclic compounds |
US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
WO1992021659A1 (en) * | 1991-05-28 | 1992-12-10 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative |
US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
NO301165B1 (en) * | 1992-12-25 | 1997-09-22 | Daiichi Seiyaku Co | Bicyclic amine derivatives and antibacterial agents containing them |
US5356903A (en) * | 1993-04-22 | 1994-10-18 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolines |
HUT67395A (en) * | 1993-07-13 | 1995-04-28 | Somfai | Method for the n-cyclopropylation of primary and secondary aromatic amines |
AU8003594A (en) * | 1993-10-28 | 1995-05-22 | Kaken Pharmaceutical Co., Ltd. | Quinolinecarboxylic acid derivative and salt thereof |
WO1996002512A1 (en) * | 1994-07-18 | 1996-02-01 | Ube Industries, Ltd. | Trifluoromethylquinolinecarboxylic acid derivative |
IN186245B (en) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
US6552217B2 (en) | 2000-08-01 | 2003-04-22 | Eastman Chemical Company | Process for the preparation of alkyl 1-methylcyclopropanecarboxylate |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1349124A (en) * | 1961-08-23 | 1964-01-17 | Smith Kline French Lab | Process for the preparation of cyclopropyl amines |
US3856976A (en) * | 1971-04-23 | 1974-12-24 | Shell Oil Co | Cyclopropane derivative fungicides |
DE2817661A1 (en) * | 1977-04-26 | 1978-11-02 | Glaxo Lab Ltd | NEW ISOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
EP0191185A1 (en) * | 1984-12-14 | 1986-08-20 | Daiichi Seiyaku Co., Ltd. | Quinoline-carboxylic acid derivatives |
GB2188317A (en) * | 1986-02-25 | 1987-09-30 | Otsuka Pharma Co Ltd | 4-oxo-quinoline compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS581742B2 (en) * | 1973-05-30 | 1983-01-12 | 株式会社日立製作所 | Bunko Koudokei |
JPS5845426B2 (en) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | Substituted quinoline carboxylic acid derivatives |
DE3033157A1 (en) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
DE3142854A1 (en) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
AU537813B2 (en) * | 1981-02-10 | 1984-07-12 | Kyorin Seiyaku K.K. | Quinoline carboxylic acid derivatives |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
DE3248506A1 (en) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7 (ALKYL-1-PIPERAZINYL) -3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
DE3248507A1 (en) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | MICROBICIDE AGENTS BASED ON CHINOLONIC CARBONIC ACID |
DE3306771A1 (en) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
DE3318145A1 (en) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
DE3420770A1 (en) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (3-OXO-1-PIPERAZINYL) -3-CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
JPS61176557A (en) * | 1985-01-31 | 1986-08-08 | Sumitomo Chem Co Ltd | Optically active 2,2-dimethylcyclopropylamine and production thereof |
-
1985
- 1985-03-16 DE DE19853509546 patent/DE3509546A1/en not_active Withdrawn
-
1986
- 1986-02-27 US US06/834,170 patent/US4705788A/en not_active Expired - Lifetime
- 1986-03-03 EP EP86102769A patent/EP0198192B1/en not_active Expired - Lifetime
- 1986-03-03 DE DE8686102769T patent/DE3685248D1/en not_active Expired - Lifetime
- 1986-03-03 AT AT86102769T patent/ATE76074T1/en active
- 1986-03-03 EP EP88107985A patent/EP0300155A3/en not_active Withdrawn
- 1986-03-15 JP JP61056105A patent/JPS61218575A/en active Granted
-
1992
- 1992-06-30 JP JP4194644A patent/JP2504895B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1349124A (en) * | 1961-08-23 | 1964-01-17 | Smith Kline French Lab | Process for the preparation of cyclopropyl amines |
US3856976A (en) * | 1971-04-23 | 1974-12-24 | Shell Oil Co | Cyclopropane derivative fungicides |
DE2817661A1 (en) * | 1977-04-26 | 1978-11-02 | Glaxo Lab Ltd | NEW ISOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
EP0191185A1 (en) * | 1984-12-14 | 1986-08-20 | Daiichi Seiyaku Co., Ltd. | Quinoline-carboxylic acid derivatives |
GB2188317A (en) * | 1986-02-25 | 1987-09-30 | Otsuka Pharma Co Ltd | 4-oxo-quinoline compounds |
Non-Patent Citations (5)
Title |
---|
CHEMICAL ABSTRACTS, Band 106, Nr. 9, 2. März 1987, Seite 565, Abstract Nr. 66799f, Columbus, Ohio, US; & JP-A-61 176 557 (SUMITOMO CHEMICAL CO. LTD) 08-08-1986 * |
CHEMICAL ABSTRACTS, Band 97, Nr. 11, 13. September 1982, Seite 725, Zusammenfassung Nr. 91782y, Columbus, Ohio, US; O.G. KULINKOVICH et al.: "Convenient method for the preparation of 2,2-dichlorocyclopropyl alkyl and aryl ketones", & ZH. ORG. KHIM. 1982, 18(5), 991-5 * |
CHEMICAL ABSTRACTS, Band 98, Nr. 3, 17. Januar 1983, Seite 455, Zusammenfassung Nr. 16037b, Columbus, Ohio, US; V.L. LEBEDEV et al.: "Quantum-chemical study of the electronic structure of chlorocyclopropanes and hydrogenolysis of carbon-chlorine bonds in gem-dichlorocyclopropanes", & IZV. AKAD. NAUK SSSR, SER. KHIM. 1982, (9), 1962-5 * |
SYNTHESIS INTERNATIONAL JOURNAL OF METHODS IN SYNTHETIC ORGANIC CHEMISTRY, Nr. 4, April 1982, Seiten 268-270, Georg Thieme Verlag, Stuttgart, DE; I.G. TISCHENKO et al.: "N,N,-dialkyl-4-oxoalkanamides from gem-dichlorocyclopropyl ketones" * |
TETRAHEDRON, Band 42, Nr. 1, Januar 1986, Seiten 239-244, Pergamon Press, Oxford, GB; F.T. DeWEESE et al.: "Regiospecificity in the nucleophilic ring opening reactions of gem-Dichlorocyclopropylcanbinyl cations" * |
Also Published As
Publication number | Publication date |
---|---|
JPH0560827B2 (en) | 1993-09-03 |
ATE76074T1 (en) | 1992-05-15 |
JP2504895B2 (en) | 1996-06-05 |
EP0198192A1 (en) | 1986-10-22 |
DE3509546A1 (en) | 1986-09-25 |
JPS61218575A (en) | 1986-09-29 |
US4705788A (en) | 1987-11-10 |
EP0198192B1 (en) | 1992-05-13 |
JPH05213836A (en) | 1993-08-24 |
DE3685248D1 (en) | 1992-06-17 |
EP0300155A2 (en) | 1989-01-25 |
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Legal Events
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Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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R18W | Application withdrawn (corrected) |
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