ES426336A1 - Naphthyridine derivatives - Google Patents

Naphthyridine derivatives

Info

Publication number
ES426336A1
ES426336A1 ES426336A ES426336A ES426336A1 ES 426336 A1 ES426336 A1 ES 426336A1 ES 426336 A ES426336 A ES 426336A ES 426336 A ES426336 A ES 426336A ES 426336 A1 ES426336 A1 ES 426336A1
Authority
ES
Spain
Prior art keywords
carbon atoms
atoms
symbols
part contains
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES426336A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7317516A external-priority patent/FR2229400A1/en
Priority claimed from FR7408728A external-priority patent/FR2286642A2/en
Priority claimed from FR7408730A external-priority patent/FR2263752A1/en
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES426336A1 publication Critical patent/ES426336A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedure for preparing naphthyridine derivatives, of general formula: ** (See formula) ** in which: one of the symbols = X - represents = N- and the other three each represent a group (see graph) in which Y represents a hydrogen or halogen atom or an alkyl radical containing from 1 to 4 carbon atoms, alkyloxy whose alkyl part contains from 1 to 4 carbon atoms, cyano or nitro; being able to be the symbols Y of the three groups (see graph) identical or different, the symbols = A - and = A1 - represent a group = OH - o = N, it being understood that when = A - represents = CH -, - A1- represents = CH - o = N - and when A represents = N -, = A1- represents = N-, the symbols Z represent atoms or radicals, identical or different, chosen from hydrogen and halogen atoms and the alkyl radicals contain from 1 to 4 carbon atoms, alkyloxyls whose alkyl part contains from 1 to 4 carbon and nitro atoms, and 1) n equals zero and R represents a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms, alkenyl with 2 to 4 carbon atoms, alkynyl with 2 to 4 carbon atoms, hydroxy alkyl whose alkyl part contains 1 to 4 carbon or phenyl atoms, or 2) n is equal to 1 and R represents an alkyl radical containing from 1 to 4 carbon atoms, hydroxyalkyl whose alkyl part contains from 1 to 4 carbon atoms or phenyl, as well as their addition salts with the acids; characterized in that a piperazine of general formula is reacted: ** (See formula) ** where n and R are defined as above, with a mixed carbonate of general formula: ** (See formula) ** where X, A, A1 and z are defined as above and Ar represents an optionally substituted phenyl radical; - and then the product obtained is eventually transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
ES426336A 1973-05-15 1974-05-14 Naphthyridine derivatives Expired ES426336A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7317516A FR2229400A1 (en) 1973-05-15 1973-05-15 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants
FR7408728A FR2286642A2 (en) 1974-03-14 1974-03-14 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants
FR7408730A FR2263752A1 (en) 1974-03-14 1974-03-14 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants

Publications (1)

Publication Number Publication Date
ES426336A1 true ES426336A1 (en) 1976-07-01

Family

ID=27250114

Family Applications (2)

Application Number Title Priority Date Filing Date
ES426335A Expired ES426335A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives
ES426336A Expired ES426336A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES426335A Expired ES426335A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives

Country Status (23)

Country Link
JP (1) JPS5758345B2 (en)
AR (2) AR209421A1 (en)
AT (1) AT336030B (en)
CH (2) CH592662A5 (en)
CS (1) CS191881B2 (en)
DD (1) DD111078A5 (en)
DE (1) DE2423650A1 (en)
DK (1) DK136819B (en)
ES (2) ES426335A1 (en)
FI (1) FI55659C (en)
GB (1) GB1417935A (en)
HU (1) HU169609B (en)
IE (1) IE39263B1 (en)
IL (1) IL44815A (en)
LU (1) LU70071A1 (en)
NL (1) NL7406194A (en)
NO (1) NO140012C (en)
OA (1) OA04700A (en)
PH (1) PH11400A (en)
PL (1) PL90061B1 (en)
SE (1) SE410857B (en)
SU (2) SU583757A3 (en)
YU (2) YU133674A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS537455B1 (en) * 1971-02-01 1978-03-17
FR2324305A2 (en) * 1975-09-22 1977-04-15 Rhone Poulenc Ind NEW DERIVATIVES OF ISOINDOLINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
AR208414A1 (en) * 1974-11-07 1976-12-27 Rhone Poulenc Ind PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2)
FR2322600A1 (en) * 1975-09-04 1977-04-01 Rhone Poulenc Ind Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)
OA05287A (en) * 1975-04-07 1981-02-28 Rhone Poulenc Ind New heterocyclic compounds and their preparation.
JPS5546257A (en) * 1978-09-27 1980-03-31 Hitachi Cable Flame retardant cable
JPS5546256A (en) * 1978-09-27 1980-03-31 Hitachi Cable Flame retardant insulated wire
JPS63191981U (en) * 1987-05-30 1988-12-09
CA2184919C (en) * 1995-01-11 2000-03-14 Eui-Hwan Cho New piperazine derivatives and methods for the preparation thereof and compositions containing the same
ATE241600T1 (en) * 1996-06-29 2003-06-15 Samjin Pharm Co Ltd PIPERAZINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
HU169609B (en) 1976-12-28
CS191881B2 (en) 1979-07-31
JPS5758345B2 (en) 1982-12-09
NO741744L (en) 1974-11-18
ES426335A1 (en) 1976-09-01
GB1417935A (en) 1975-12-17
JPS5040593A (en) 1975-04-14
IE39263L (en) 1974-11-15
LU70071A1 (en) 1975-02-24
DD111078A5 (en) 1975-01-20
CH592663A5 (en) 1977-10-31
IE39263B1 (en) 1978-08-30
DK136819C (en) 1978-05-16
AU6888074A (en) 1975-11-13
PH11400A (en) 1977-12-14
YU133674A (en) 1983-01-21
IL44815A0 (en) 1975-02-10
CH592662A5 (en) 1977-10-31
AR210851A1 (en) 1977-09-30
FI55659B (en) 1979-05-31
SU583757A3 (en) 1977-12-05
DE2423650A1 (en) 1974-12-05
AT336030B (en) 1977-04-12
FI55659C (en) 1979-09-10
OA04700A (en) 1980-07-31
SE410857B (en) 1979-11-12
NL7406194A (en) 1974-11-19
NO140012B (en) 1979-03-12
SU589916A3 (en) 1978-01-25
IL44815A (en) 1977-12-30
AR209421A1 (en) 1977-04-29
DK136819B (en) 1977-11-28
YU287781A (en) 1983-01-21
NO140012C (en) 1979-06-20
PL90061B1 (en) 1976-12-31
ATA400874A (en) 1976-08-15

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