IE37134B1 - Antibacterial compositions - Google Patents

Info

Publication number

IE37134B1

IE37134B1 IE100/73A IE10073A IE37134B1 IE 37134 B1 IE37134 B1 IE 37134B1 IE 100/73 A IE100/73 A IE 100/73A IE 10073 A IE10073 A IE 10073A IE 37134 B1 IE37134 B1 IE 37134B1

Authority

IE

Ireland

Prior art keywords

alanine

fluoro

antibacterial compositions

methylisoxazolidin

cycloserine

Prior art date

1972-02-03

Links

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• 239000000203 mixture Substances 0.000 title abstract 5
• 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
• UYTSRQMXRROFPU-UWTATZPHSA-N (2s)-2-amino-3-fluoropropanoic acid Chemical compound FC[C@@H](N)C(O)=O UYTSRQMXRROFPU-UWTATZPHSA-N 0.000 abstract 4
• 150000001875 compounds Chemical class 0.000 abstract 3
• DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 abstract 2
• DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 abstract 2
• 239000012736 aqueous medium Substances 0.000 abstract 2
• 150000003839 salts Chemical class 0.000 abstract 2
• 239000000243 solution Substances 0.000 abstract 2
• UYTSRQMXRROFPU-MIRRBZTDSA-N (2s)-2-amino-2,3,3-trideuterio-3-fluoropropanoic acid Chemical compound [2H]C([2H])(F)[C@@]([2H])(N)C(O)=O UYTSRQMXRROFPU-MIRRBZTDSA-N 0.000 abstract 1
• UYTSRQMXRROFPU-BMRKBTMXSA-N (2s)-2-amino-2,3-dideuterio-3-fluoropropanoic acid Chemical compound [2H]C(F)[C@@]([2H])(N)C(O)=O UYTSRQMXRROFPU-BMRKBTMXSA-N 0.000 abstract 1
• UYTSRQMXRROFPU-LIIDHCAMSA-N (2s)-2-amino-2-deuterio-3-fluoropropanoic acid Chemical compound FC[C@](N)([2H])C(O)=O UYTSRQMXRROFPU-LIIDHCAMSA-N 0.000 abstract 1
• KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 1
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
• ODKYYBOHSVLGNU-UHFFFAOYSA-N 4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one Chemical compound O=C1NOCC1N=CC(C=C1)=CC=C1C=NC1C(=O)NOC1 ODKYYBOHSVLGNU-UHFFFAOYSA-N 0.000 abstract 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
• 102000003960 Ligases Human genes 0.000 abstract 1
• 108090000364 Ligases Proteins 0.000 abstract 1
• DEFJQIDDEAULHB-UHFFFAOYSA-N N-D-alanyl-D-alanine Natural products CC(N)C(=O)NC(C)C(O)=O DEFJQIDDEAULHB-UHFFFAOYSA-N 0.000 abstract 1
• 102000003929 Transaminases Human genes 0.000 abstract 1
• 108090000340 Transaminases Proteins 0.000 abstract 1
• 239000004480 active ingredient Substances 0.000 abstract 1
• 108010056243 alanylalanine Proteins 0.000 abstract 1
• 125000005907 alkyl ester group Chemical group 0.000 abstract 1
• 239000011575 calcium Substances 0.000 abstract 1
• 229910052791 calcium Inorganic materials 0.000 abstract 1
• 239000002775 capsule Substances 0.000 abstract 1
• 150000002148 esters Chemical class 0.000 abstract 1
• 238000001727 in vivo Methods 0.000 abstract 1
• 239000003112 inhibitor Substances 0.000 abstract 1
• 150000004702 methyl esters Chemical class 0.000 abstract 1
• 244000005700 microbiome Species 0.000 abstract 1
• 239000011734 sodium Substances 0.000 abstract 1
• 229910052708 sodium Inorganic materials 0.000 abstract 1
• 239000000725 suspension Substances 0.000 abstract 1
• 239000003826 tablet Substances 0.000 abstract 1