GB1397645A - Aza-benzimidazoles - Google Patents

Aza-benzimidazoles

Info

Publication number
GB1397645A
GB1397645A GB3940272A GB3940272A GB1397645A GB 1397645 A GB1397645 A GB 1397645A GB 3940272 A GB3940272 A GB 3940272A GB 3940272 A GB3940272 A GB 3940272A GB 1397645 A GB1397645 A GB 1397645A
Authority
GB
United Kingdom
Prior art keywords
group
chloropyridine
amino
carbethoxyamino
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3940272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of GB1397645A publication Critical patent/GB1397645A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Abstract

1397645 Pyrido-imidazoles DEUTSCHE GOLDUND SILBER-SCHEIDEANSTALT 24 Aug 1972 [26 Aug 1971] 39402/72 Heading C2C Novel compounds (I) (including salts thereof) in which R<SP>1</SP> represents a chlorine or bromine atom, R<SP>2</SP> represents a hydrogen atom or a straight chain alkyl group with 1-6 carbon atoms, R<SP>3</SP> represents a hydrogen atom, a straight chain alkyl group with 1-6 carbon atoms, benzyl or represents the group CH 2 -COOH, and Y is a hydroxy group, a mercapto group, a benzyl amino group, a straight chain alkyl-mercapto group with 1-6 carbon atoms, a #-hydroxyethylamino group, a phenylamino group, a straight chain alkyl group with 1-6 carbon atoms, benzyl or the group -SCH 2 -COOH, are made by standard methods. The following compounds are also prepared: 2- amino-3-nitro-6-ethoxypyridine, 2-amino-3-carbethoxyamino-6-ethoxypyridine, 2,6-diamino-3- carbethoxyamino-pyridine. HCl, 2,3-diamino-6- chloropyridine. HCl, 2-amino-3-carbethoxyamino- 6-chloropyridine. HCl, the Schiffs base of 2,3- diamino-6-chloropyridine and benzaldehyde, 2- amino-3-benzylamino-6-chloropyridine, 2-hydroxy- and -methoxy-3-nitro-6-chloropyridine and 2 - amino - 3 - (N - benzyl) - carbethoxyamino - 6- chloropyridine. Pharmaceutical preparations contain (I) as active ingredient and are administered orally, parenterally or topically.
GB3940272A 1971-08-26 1972-08-24 Aza-benzimidazoles Expired GB1397645A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT748871A AT315831B (en) 1971-08-26 1971-08-26 Process for the preparation of new 4-aza-benzimidazole derivatives and their salts

Publications (1)

Publication Number Publication Date
GB1397645A true GB1397645A (en) 1975-06-11

Family

ID=3596529

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3940272A Expired GB1397645A (en) 1971-08-26 1972-08-24 Aza-benzimidazoles

Country Status (19)

Country Link
JP (1) JPS4832898A (en)
AR (1) AR199879A1 (en)
AT (1) AT315831B (en)
AU (1) AU461671B2 (en)
BE (1) BE788065A (en)
BR (1) BR7205845A (en)
CA (1) CA979907A (en)
CH (1) CH592660A5 (en)
DD (1) DD99580A5 (en)
DE (1) DE2241575A1 (en)
ES (1) ES405982A1 (en)
FR (1) FR2150820B1 (en)
GB (1) GB1397645A (en)
HU (1) HU166382B (en)
IL (1) IL40080A (en)
NL (1) NL7211407A (en)
SU (1) SU557758A3 (en)
YU (1) YU34897B (en)
ZA (1) ZA725868B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005318A1 (en) * 1978-04-03 1979-11-14 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
US4772600A (en) * 1986-06-09 1988-09-20 A. H. Robins Company, Inc. Fused imidazoheterocyclic compounds and pharmaceutical compositions
US5200407A (en) * 1989-06-29 1993-04-06 Meiji Seika Kaburhiki Kaisha Azole derivatives and anti-ulcerative composition containing same
JP2679745B2 (en) * 1989-06-29 1997-11-19 明治製菓株式会社 Azole derivatives and antiulcer agents containing them as active ingredients
WO1999016438A1 (en) 1997-09-26 1999-04-08 Asta Medica Aktiengesellschaft Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
PT2583970E (en) 2006-08-02 2016-02-08 Cytokinetics Inc Certain chemical entities, compositions and methods comprising imidazopyrimidines
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
US20140113824A1 (en) 2011-05-10 2014-04-24 Bayer Intellectual Property Gmbh Bicyclic (thio)carbonylamidines
CN109316480A (en) 2011-07-13 2019-02-12 赛特凯恩蒂克公司 Combine ALS therapy
EP3495366A1 (en) * 2011-07-15 2019-06-12 Shionogi & Co., Ltd Azabenzimidazole derivative having ampk-activating activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005318A1 (en) * 1978-04-03 1979-11-14 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates

Also Published As

Publication number Publication date
AT315831B (en) 1974-06-10
FR2150820A1 (en) 1973-04-13
YU204172A (en) 1979-10-31
JPS4832898A (en) 1973-05-02
IL40080A (en) 1975-12-31
IL40080A0 (en) 1972-10-29
YU34897B (en) 1980-04-30
SU557758A3 (en) 1977-05-05
BR7205845A (en) 1976-05-04
AU4598172A (en) 1974-02-28
HU166382B (en) 1975-03-28
DD99580A5 (en) 1973-08-12
FR2150820B1 (en) 1975-10-17
AU461671B2 (en) 1975-06-05
CH592660A5 (en) 1977-10-31
BR7205845D0 (en) 1973-07-03
ZA725868B (en) 1973-05-30
CA979907A (en) 1975-12-16
ES405982A1 (en) 1975-09-16
NL7211407A (en) 1973-02-28
AR199879A1 (en) 1974-10-08
DE2241575A1 (en) 1973-03-08
BE788065A (en) 1973-02-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee