IE37134B1 - Antibacterial compositions - Google Patents

Antibacterial compositions

Info

Publication number
IE37134B1
IE37134B1 IE100/73A IE10073A IE37134B1 IE 37134 B1 IE37134 B1 IE 37134B1 IE 100/73 A IE100/73 A IE 100/73A IE 10073 A IE10073 A IE 10073A IE 37134 B1 IE37134 B1 IE 37134B1
Authority
IE
Ireland
Prior art keywords
alanine
fluoro
antibacterial compositions
methylisoxazolidin
cycloserine
Prior art date
Application number
IE100/73A
Other versions
IE37134L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE37134L publication Critical patent/IE37134L/en
Publication of IE37134B1 publication Critical patent/IE37134B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1421023 Antibacterial compositions MERCK & CO Inc 29 Jan 1973 [3 Feb 1972 13 Dec 1972] 4426/73 Heading A5B Antibacterial compositions comprise as active ingredients a mixture of 3-fluoro-D-alanine, a deuterated 3-fluoro-D-alanine, or a pharmacologically acceptable salt or ester thereof with an autoantagonist inhibitor, which is a compound that has the ability, or that is converted in aqueous media to a compound having the ability, to inhibit the action of the D-alanyl-D-alanine synthetase and/or D-alanine; α-ketoglutarate transaminase enzymes of microorganisms, e.g. D-cycloserine, 1, 4-bis-(3- oxoisoxazolidin-4-yliminomethyl) benzene, D- (cis or trans)-4-amino-5-methylisoxazolidin-3- one and compounds that in vivo or in solution in an aqueous medium liberate D-cycloserine, D-(cis or trans)-4-amino-5-methylisoxazolidin- 3-one. The 3-fluoro-D-alanine component may be 3-fluoro-D-alanine, 2-deutero-3-fluoro-D-alanine, 2, 3-dideutero-3-fluoro-D-alanine, 2, 3, 3- trideutero-3-fluoro - D - alanine, a C 1-5 alkyl ester thereof such as the methyl ester, or a pharmacologically acceptable salt such as the sodium, calcium or hydrochloride salt. The compositions may be administered orally or parenterally in the form of capsules, tablets, solutions or suspensions. [GB1421023A]
IE100/73A 1972-02-03 1973-01-23 Antibacterial compositions IE37134B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22336072A 1972-02-03 1972-02-03
US31487872A 1972-12-13 1972-12-13

Publications (2)

Publication Number Publication Date
IE37134L IE37134L (en) 1973-08-03
IE37134B1 true IE37134B1 (en) 1977-05-11

Family

ID=26917692

Family Applications (1)

Application Number Title Priority Date Filing Date
IE100/73A IE37134B1 (en) 1972-02-03 1973-01-23 Antibacterial compositions

Country Status (9)

Country Link
BE (1) BE794913A (en)
CA (1) CA1024448A (en)
DE (1) DE2262787C2 (en)
FR (1) FR2181703B1 (en)
GB (1) GB1421023A (en)
HK (1) HK86479A (en)
IE (1) IE37134B1 (en)
IL (1) IL41358A (en)
NL (1) NL177183C (en)

Also Published As

Publication number Publication date
GB1421023A (en) 1976-01-14
FR2181703B1 (en) 1975-11-21
DE2262787C2 (en) 1982-09-23
FR2181703A1 (en) 1973-12-07
CA1024448A (en) 1978-01-17
NL177183B (en) 1985-03-18
IL41358A (en) 1976-03-31
BE794913A (en) 1973-08-02
NL177183C (en) 1985-08-16
NL7300636A (en) 1973-08-07
IL41358A0 (en) 1973-03-30
IE37134L (en) 1973-08-03
DE2262787A1 (en) 1973-08-09
HK86479A (en) 1979-12-28

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