ID27000A - Proses untuk pemisahan enansiomer-enansiomer 3 (r)-dan 3 (s)-hidroksi-1-metil-4(2,4,66-trimetoksifenil) -1,2,3,6-tetrahidropiridina atau ester-ester asam karboksilat - Google Patents
Proses untuk pemisahan enansiomer-enansiomer 3 (r)-dan 3 (s)-hidroksi-1-metil-4(2,4,66-trimetoksifenil) -1,2,3,6-tetrahidropiridina atau ester-ester asam karboksilatInfo
- Publication number
- ID27000A ID27000A IDW20001691A ID20001691A ID27000A ID 27000 A ID27000 A ID 27000A ID W20001691 A IDW20001691 A ID W20001691A ID 20001691 A ID20001691 A ID 20001691A ID 27000 A ID27000 A ID 27000A
- Authority
- ID
- Indonesia
- Prior art keywords
- enansiomer
- trymethophenphenyl
- tetrahidropiridine
- hydrocysi
- carboxicylic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000008569 process Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19809649A DE19809649A1 (de) | 1998-03-06 | 1998-03-06 | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID27000A true ID27000A (id) | 2001-02-22 |
Family
ID=7859957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW20001691A ID27000A (id) | 1998-03-06 | 1999-02-20 | Proses untuk pemisahan enansiomer-enansiomer 3 (r)-dan 3 (s)-hidroksi-1-metil-4(2,4,66-trimetoksifenil) -1,2,3,6-tetrahidropiridina atau ester-ester asam karboksilat |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6406912B1 (cs) |
| EP (1) | EP1071807B1 (cs) |
| JP (1) | JP4344089B2 (cs) |
| KR (1) | KR100779864B1 (cs) |
| CN (1) | CN1230554C (cs) |
| AR (1) | AR018574A1 (cs) |
| AT (1) | ATE474061T1 (cs) |
| AU (1) | AU758106B2 (cs) |
| BR (2) | BRPI9908557B8 (cs) |
| CA (1) | CA2322842C (cs) |
| CY (1) | CY1110919T1 (cs) |
| CZ (1) | CZ301944B6 (cs) |
| DE (2) | DE19809649A1 (cs) |
| DK (1) | DK1071807T3 (cs) |
| ES (1) | ES2348394T3 (cs) |
| HU (1) | HU227994B1 (cs) |
| ID (1) | ID27000A (cs) |
| PL (1) | PL195006B1 (cs) |
| PT (1) | PT1071807E (cs) |
| RU (1) | RU2241040C2 (cs) |
| TR (1) | TR200002576T2 (cs) |
| WO (1) | WO1999045133A1 (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID30551A (id) | 1999-05-13 | 2001-12-20 | Shell Int Research | Proses konversi hidrokarbon |
| KR100897597B1 (ko) | 2001-05-15 | 2009-05-14 | 스페델 파르마 아게 | 치환된 카르복실산 에스테르의 제조방법 |
| CN104232700A (zh) * | 2014-10-01 | 2014-12-24 | 青岛科技大学 | 一种生物法生产(2r,3s)羟基丙酸甲酯的方法 |
| CN104278061A (zh) * | 2014-10-01 | 2015-01-14 | 青岛科技大学 | 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法 |
| EP3611506B1 (en) | 2015-04-20 | 2021-11-17 | Sumitomo Dainippon Pharma Oncology, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| JP6510075B2 (ja) | 2015-05-18 | 2019-05-08 | トレロ ファーマシューティカルズ， インコーポレイテッド | バイオアベイラビリティが高いアルボシジブプロドラッグ |
| BR112018002427A8 (pt) | 2015-08-03 | 2022-10-18 | Tolero Pharmaceuticals Inc | Uso de alvocidib e de azacitidina ou decitabina para tratar câncer e kit e composição farmacêutica contendo as ditas substâncias |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| KR20190099260A (ko) | 2016-12-19 | 2019-08-26 | 톨레로 파마수티컬스, 인크. | 프로파일링 펩티드 및 감도 프로파일링을 위한 방법 |
| US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
| AU2019391097B2 (en) | 2018-12-04 | 2025-07-03 | Sumitomo Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
| CN110577974B (zh) * | 2019-09-10 | 2021-07-20 | 杭州澳赛诺生物科技有限公司 | 手性3-羟基-1,2,3,6-四氢吡啶的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2691986B2 (ja) * | 1987-08-28 | 1997-12-17 | チッソ株式会社 | ピリジン骨格を有する光学活性化合物の製造法 |
| DE3743824C2 (de) | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| JPH0641075A (ja) | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
| CA2064676A1 (en) | 1991-04-02 | 1992-10-03 | Manfred Schneider | Immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor |
| JPH0690790A (ja) * | 1992-09-08 | 1994-04-05 | Mercian Corp | 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法 |
| DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
-
1998
- 1998-03-06 DE DE19809649A patent/DE19809649A1/de not_active Withdrawn
-
1999
- 1999-02-20 HU HU0101795A patent/HU227994B1/hu unknown
- 1999-02-20 ID IDW20001691A patent/ID27000A/id unknown
- 1999-02-20 WO PCT/EP1999/001113 patent/WO1999045133A1/de active IP Right Grant
- 1999-02-20 JP JP2000534664A patent/JP4344089B2/ja not_active Expired - Lifetime
- 1999-02-20 PL PL342877A patent/PL195006B1/pl unknown
- 1999-02-20 PT PT99910248T patent/PT1071807E/pt unknown
- 1999-02-20 TR TR2000/02576T patent/TR200002576T2/xx unknown
- 1999-02-20 CN CNB998035955A patent/CN1230554C/zh not_active Expired - Lifetime
- 1999-02-20 CA CA2322842A patent/CA2322842C/en not_active Expired - Lifetime
- 1999-02-20 DE DE59915183T patent/DE59915183D1/de not_active Expired - Lifetime
- 1999-02-20 AU AU29275/99A patent/AU758106B2/en not_active Expired
- 1999-02-20 DK DK99910248.6T patent/DK1071807T3/da active
- 1999-02-20 BR BRPI9908557A patent/BRPI9908557B8/pt unknown
- 1999-02-20 CZ CZ20003223A patent/CZ301944B6/cs not_active IP Right Cessation
- 1999-02-20 RU RU2000125273/13A patent/RU2241040C2/ru active
- 1999-02-20 EP EP99910248A patent/EP1071807B1/de not_active Expired - Lifetime
- 1999-02-20 US US09/623,563 patent/US6406912B1/en not_active Expired - Lifetime
- 1999-02-20 AT AT99910248T patent/ATE474061T1/de active
- 1999-02-20 ES ES99910248T patent/ES2348394T3/es not_active Expired - Lifetime
- 1999-02-20 KR KR1020007009843A patent/KR100779864B1/ko not_active Expired - Lifetime
- 1999-02-20 BR BR9908557-7A patent/BR9908557A/pt not_active IP Right Cessation
- 1999-03-04 AR ARP990100907A patent/AR018574A1/es active IP Right Grant
-
2010
- 2010-09-22 CY CY20101100850T patent/CY1110919T1/el unknown
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