ID17468A - Senyawa-senyawa xanthin yang mempunyai terminal rantai-rantai cabang alkunol teraminasi - Google Patents

Senyawa-senyawa xanthin yang mempunyai terminal rantai-rantai cabang alkunol teraminasi

Info

Publication number
ID17468A
ID17468A IDP971927A ID971927A ID17468A ID 17468 A ID17468 A ID 17468A ID P971927 A IDP971927 A ID P971927A ID 971927 A ID971927 A ID 971927A ID 17468 A ID17468 A ID 17468A
Authority
ID
Indonesia
Prior art keywords
alkunol
amused
xanthin
branches
compounds
Prior art date
Application number
IDP971927A
Other languages
English (en)
Indonesian (id)
Inventor
Ulrich Dr Gebert
Elisabeth Dr Defossa
Uwe Dr Heinelt
Karl Dr Rudolphi
John J Dr Grome
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19622734A external-priority patent/DE19622734A1/de
Priority claimed from DE1996136882 external-priority patent/DE19636882A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ID17468A publication Critical patent/ID17468A/id

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IDP971927A 1996-06-07 1997-06-05 Senyawa-senyawa xanthin yang mempunyai terminal rantai-rantai cabang alkunol teraminasi ID17468A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19622734A DE19622734A1 (de) 1996-06-07 1996-06-07 Xanthinverbindungen mit terminal aminierten Alkinol-Seitenketten
DE1996136882 DE19636882A1 (de) 1996-09-11 1996-09-11 Xanthinverbindungen mit terminal aminierten Alkinol-Seitenketten

Publications (1)

Publication Number Publication Date
ID17468A true ID17468A (id) 1998-01-08

Family

ID=26026371

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP971927A ID17468A (id) 1996-06-07 1997-06-05 Senyawa-senyawa xanthin yang mempunyai terminal rantai-rantai cabang alkunol teraminasi

Country Status (26)

Country Link
US (1) US5965555A (es)
EP (1) EP0811623B1 (es)
JP (1) JP4263778B2 (es)
KR (1) KR100531964B1 (es)
CN (1) CN1064361C (es)
AR (1) AR013821A1 (es)
AT (1) ATE200288T1 (es)
AU (1) AU712717B2 (es)
BR (1) BR9703500B1 (es)
CA (1) CA2207258C (es)
CZ (1) CZ292509B6 (es)
DE (1) DE59703271D1 (es)
DK (1) DK0811623T3 (es)
ES (1) ES2155640T3 (es)
GR (1) GR3035711T3 (es)
HU (1) HU224702B1 (es)
ID (1) ID17468A (es)
IL (1) IL120998A (es)
MX (1) MX9704201A (es)
MY (1) MY117764A (es)
NO (1) NO307787B1 (es)
NZ (1) NZ328018A (es)
PL (1) PL186238B1 (es)
PT (1) PT811623E (es)
RU (1) RU2204561C2 (es)
TW (1) TW384289B (es)

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GB2284708A (en) * 1993-12-07 1995-06-14 At & T Corp Method for passivation of multi-quantum well infrared photodetectors (QWIPS) to reduce dark current and to improve dark current uniformity
AU2002234640B8 (en) * 2001-02-24 2009-11-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivative, production and use thereof as a medicament
WO2003008559A2 (en) * 2001-07-19 2003-01-30 Medical College Of Georgia Research Institute Novel analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
US7407955B2 (en) * 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
UA84275C2 (ru) * 2002-08-21 2008-10-10 Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг 8-[3-аминопиперидин-1-ил]ксантины, способ их получения и их применение как лекарственных средств
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) * 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
JP5323684B2 (ja) * 2006-05-04 2013-10-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 多形体
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
JP5769966B2 (ja) * 2007-08-17 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Fab関連疾患治療用プリン誘導体
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
EP2326326B1 (en) * 2008-08-15 2019-10-09 Boehringer Ingelheim International GmbH Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients
CN102149407A (zh) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN107011345A (zh) 2008-12-23 2017-08-04 勃林格殷格翰国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EP2504002B1 (en) 2009-11-27 2019-10-09 Boehringer Ingelheim International GmbH Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
NZ603319A (en) 2010-06-24 2015-04-24 Boehringer Ingelheim Int Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
PL2731947T3 (pl) 2011-07-15 2019-07-31 Boehringer Ingelheim International Gmbh Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
EP4233840A3 (en) 2016-06-10 2023-10-18 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007197A (en) * 1975-06-10 1977-02-08 The Dow Chemical Company Process for preparing phosphorothioates and phenylphosphonothioates
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
GB8621870D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Active compounds
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
IT1274241B (it) * 1993-12-03 1997-07-15 Smithkline Beecham Farma Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
CN1064361C (zh) 2001-04-11
DK0811623T3 (da) 2001-07-23
US5965555A (en) 1999-10-12
CZ174297A3 (en) 1997-12-17
MY117764A (en) 2004-08-30
BR9703500B1 (pt) 2010-05-18
CZ292509B6 (cs) 2003-10-15
ES2155640T3 (es) 2001-05-16
DE59703271D1 (de) 2001-05-10
BR9703500A (pt) 1998-10-06
HUP9701018A3 (en) 2000-01-28
EP0811623B1 (de) 2001-04-04
AU2469997A (en) 1997-12-11
IL120998A (en) 2000-07-16
CN1169994A (zh) 1998-01-14
HU9701018D0 (en) 1997-07-28
KR19980024046A (ko) 1998-07-06
MX9704201A (es) 1998-04-30
TW384289B (en) 2000-03-11
NO972581L (no) 1997-12-08
JP4263778B2 (ja) 2009-05-13
CA2207258C (en) 2006-08-08
CA2207258A1 (en) 1997-12-07
IL120998A0 (en) 1997-11-20
AU712717B2 (en) 1999-11-11
AR013821A1 (es) 2001-01-31
NO307787B1 (no) 2000-05-29
NO972581D0 (no) 1997-06-06
JPH1059968A (ja) 1998-03-03
ATE200288T1 (de) 2001-04-15
NZ328018A (en) 1998-09-24
PL186238B1 (pl) 2003-12-31
HU224702B1 (en) 2006-01-30
PT811623E (pt) 2001-09-28
GR3035711T3 (en) 2001-07-31
EP0811623A1 (de) 1997-12-10
KR100531964B1 (ko) 2006-03-17
HUP9701018A2 (hu) 1998-12-28
PL320414A1 (en) 1997-12-08
RU2204561C2 (ru) 2003-05-20

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