HUT74105A - Indolin-2-one-derivatives - Google Patents

Indolin-2-one-derivatives Download PDF

Info

Publication number
HUT74105A
HUT74105A HU9502415A HU9502415A HUT74105A HU T74105 A HUT74105 A HU T74105A HU 9502415 A HU9502415 A HU 9502415A HU 9502415 A HU9502415 A HU 9502415A HU T74105 A HUT74105 A HU T74105A
Authority
HU
Hungary
Prior art keywords
optionally substituted
lower alkyl
indolin
ureido
methylphenyl
Prior art date
Application number
HU9502415A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9502415D0 (en
Inventor
Takashi Emura
Toru Esaki
Eiichi Hoshino
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of HU9502415D0 publication Critical patent/HU9502415D0/hu
Publication of HUT74105A publication Critical patent/HUT74105A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HU9502415A 1993-02-17 1994-02-17 Indolin-2-one-derivatives HUT74105A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6729793 1993-02-17
JP16726293 1993-05-31

Publications (2)

Publication Number Publication Date
HU9502415D0 HU9502415D0 (en) 1996-05-28
HUT74105A true HUT74105A (en) 1996-11-28

Family

ID=26408486

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9502415A HUT74105A (en) 1993-02-17 1994-02-17 Indolin-2-one-derivatives

Country Status (19)

Country Link
US (5) US5952511A (enExample)
EP (1) EP0685463B1 (enExample)
JP (1) JP3419539B2 (enExample)
KR (1) KR100226310B1 (enExample)
CN (1) CN1046268C (enExample)
AT (1) ATE217864T1 (enExample)
AU (1) AU6044894A (enExample)
CA (1) CA2156287C (enExample)
CZ (1) CZ290504B6 (enExample)
DE (1) DE69430664T2 (enExample)
ES (1) ES2176236T3 (enExample)
FI (1) FI112652B (enExample)
HU (1) HUT74105A (enExample)
MY (1) MY128102A (enExample)
NO (1) NO305201B1 (enExample)
PL (1) PL176710B1 (enExample)
RU (1) RU2128170C1 (enExample)
TW (1) TW281669B (enExample)
WO (1) WO1994019322A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5783701A (en) 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0731091T3 (da) * 1993-11-26 2002-04-15 Tanabe Seiyaku Co 2-oxoindolin-derivater som cholecystokininreceptor-antagonister
MX9603909A (es) * 1994-03-07 1997-03-29 Vertex Pharma Derivados de sulfonamida como inhibidores de proteasa aspartilo.
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
AU2233097A (en) * 1996-03-11 1997-10-01 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of optically active indole compounds
WO1998002419A1 (en) * 1996-07-12 1998-01-22 Chugai Seiyaku Kabushiki Kaisha Cancer cell proliferation inhibitors
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
ATE285769T1 (de) * 1998-12-04 2005-01-15 Neurosearch As Verwendung von isatinderivaten als ionenkanalaktivierende mittel
US6605623B1 (en) 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1156037B1 (en) 1999-01-29 2004-12-01 Chugai Seiyaku Kabushiki Kaisha Chondrongenesis promotors and indolin-2-one derivatives
DE60041763D1 (de) * 1999-04-23 2009-04-23 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
KR20100035666A (ko) 1999-11-23 2010-04-05 메틸진 인크. 히스톤 디아세틸라제의 억제제
AU2001236058A1 (en) * 2000-03-10 2001-09-17 Chugai Seiyaku Kabushiki Kaisha Preparations for chondrogenesis
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
AU2001268607A1 (en) 2000-06-21 2002-01-02 Bristol-Myers Squibb Company Piperidine amides as modulators of chemokine receptor activity
AU2001271357A1 (en) * 2000-06-21 2002-01-02 Dupont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
CN1324009C (zh) * 2003-01-30 2007-07-04 普文英 化合物1－n－甲氧基－2－氧－吲哚－3－乙酰胺及其药物用途
KR101249865B1 (ko) * 2004-10-27 2013-04-02 깃세이 야쿠힌 고교 가부시키가이샤 인돌린 화합물 및 그 제조방법
US20080030974A1 (en) * 2006-08-02 2008-02-07 Abu-Ageel Nayef M LED-Based Illumination System
US20090050905A1 (en) * 2007-08-20 2009-02-26 Abu-Ageel Nayef M Highly Efficient Light-Emitting Diode
US20100202129A1 (en) * 2009-01-21 2010-08-12 Abu-Ageel Nayef M Illumination system utilizing wavelength conversion materials and light recycling
US8987310B2 (en) 2009-10-30 2015-03-24 Merck Sharp & Dohme Corp. Heterocycle amide T-type calcium channel antagonists
CN102516153B (zh) * 2011-12-14 2014-03-12 南京工业大学 5-氟吲哚-2-酮-3-脲类化合物及其制备方法和应用
RU2693484C1 (ru) 2013-11-22 2019-07-03 СиЭль БАЙОСАЕНСИЗ ЭлЭлСи Антагонисты гастрина для лечения и профилактики остеопороза
KR102161674B1 (ko) * 2014-02-18 2020-10-05 주식회사 대웅제약 이사틴 유도체 및 이의 제조방법
CN113456631B (zh) * 2021-08-06 2022-06-21 徐州医科大学 一种靶向acsl1的小分子药物及其在治疗子宫内膜癌中的应用
CN117777002A (zh) * 2023-12-04 2024-03-29 华南理工大学 一种3,3-二取代氧化吲哚衍生物的不对称合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
JPS62228072A (ja) 1985-12-20 1987-10-06 Kissei Pharmaceut Co Ltd ３−アミノインドリン−２−オン誘導体
JPS62234080A (ja) 1985-12-20 1987-10-14 Kissei Pharmaceut Co Ltd インドリン−２−オン誘導体
US4760083A (en) 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
JPS62270576A (ja) 1986-05-19 1987-11-24 Kissei Pharmaceut Co Ltd イサチン誘導体
JPS62156771A (ja) * 1986-12-19 1987-07-11 Tokyo Shokai:Kk 処方箋処理装置
JPS63156771A (ja) 1986-12-19 1988-06-29 Kissei Pharmaceut Co Ltd ３−アミノインドリン−２−オン誘導体
US4876259A (en) * 1987-01-05 1989-10-24 E. I. Du Pont De Nemours And Company 3,3-disubstituted indolines
JPH03503650A (ja) * 1988-04-05 1991-08-15 アボツト・ラボラトリーズ Ｃｃｋアンタゴニストとしてのトリプトファン誘導体
CA2088980C (en) * 1990-08-31 2002-04-16 David C. Horwell Pro-drugs for cck antagonists
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
CA2055094A1 (en) * 1990-11-13 1992-05-14 Mark G. Bock Cholecystokinin antagonist
JPH05104510A (ja) * 1991-10-18 1993-04-27 Inax Corp 基板へのモルタル塗布方法

Also Published As

Publication number Publication date
KR960701011A (ko) 1996-02-24
PL310168A1 (en) 1995-11-27
CZ209695A3 (en) 1995-12-13
RU2128170C1 (ru) 1999-03-27
US6031111A (en) 2000-02-29
CZ290504B6 (cs) 2002-08-14
TW281669B (enExample) 1996-07-21
NO305201B1 (no) 1999-04-19
KR100226310B1 (ko) 1999-10-15
NO953235L (no) 1995-10-09
US6207836B1 (en) 2001-03-27
US6127544A (en) 2000-10-03
ES2176236T3 (es) 2002-12-01
US6114536A (en) 2000-09-05
DE69430664D1 (de) 2002-06-27
US5952511A (en) 1999-09-14
FI953866A0 (fi) 1995-08-16
JP3419539B2 (ja) 2003-06-23
EP0685463A4 (enExample) 1996-01-03
CN1046268C (zh) 1999-11-10
ATE217864T1 (de) 2002-06-15
FI112652B (fi) 2003-12-31
CA2156287A1 (en) 1994-09-01
PL176710B1 (pl) 1999-07-30
NO953235D0 (no) 1995-08-17
DE69430664T2 (de) 2003-01-30
HU9502415D0 (en) 1996-05-28
CN1117727A (zh) 1996-02-28
WO1994019322A1 (en) 1994-09-01
CA2156287C (en) 2005-12-27
JPH0748349A (ja) 1995-02-21
EP0685463B1 (en) 2002-05-22
EP0685463A1 (en) 1995-12-06
MY128102A (en) 2007-01-31
AU6044894A (en) 1994-09-14
FI953866A7 (fi) 1995-08-16

Similar Documents

Publication Publication Date Title
US6207836B1 (en) Indolin-2-one derivatives
US5004741A (en) Methods of antagonizing CCK or gastrin with benzodiazepine analogs
JP3263081B2 (ja) バソプレシンおよび／またはオシトシン作動薬および／または拮抗薬としての窒素基によって３位において置換されている１，３−ジヒドロインドール−２−オン誘導体
US4820834A (en) Benzodiazepine analogs
EP1105376B1 (en) Oxindole derivatives as growth hormone releasers
RU2591190C2 (ru) Новые 4-амино-n-гидроксибензамиды в качестве ингибиторов hdac для лечения рака
HU211970A9 (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them
SE452459B (sv) Indol-5-metansulfonamid, en farmaceutisk komposition och ett forfarande for framstellning av foreningen
AU2005224129B2 (en) Novel azabicyclic derivatives, preparation method thereof and pharmaceutical compositions containing same
SK121397A3 (en) Di-substituted 1,4-piperidine esters and amides having 5-ht4 antagonistic activity, producing method and their use
PT1668985E (pt) Ecteinascidinas e n-óxidos de ecteinascidinas com substituições nucleofílicas
UA78536C2 (en) Indolylalkylamine derivatives as ligands of 5-hydroxytryptamine-6, method of production (variants), pharmaceutical composition
UA75060C2 (en) Substituted n-benzyl-indole-3-yl-glyoxylic acid derivatives having antitumor activity, use thereof and pharmaceutical composition based thereon
CN1980934B (zh) 作为选择性雄激素受体调节剂（sarms）的新的吲哚衍生物
US5919946A (en) Synthesis of indolylmaleimides
JP4332902B2 (ja) 新規ジヒドロピリジン誘導体
US20110059966A1 (en) Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other cns disorders
CZ172796A3 (en) 3-substituted 1-arylindole derivatives, their use and pharmaceutical compositions containing thereof
Sánchez et al. Synthesis of 5-N-acetylardeemin seco-analogues
US5157122A (en) Process for the preparation of 3-unsubstituted indoles using methane sulfonic acid as an additional catalyst
EP0572235A2 (en) Beta-carboline derivatives with anticholecystoquinine activity
JPH0525140A (ja) ベンズイミダゾール誘導体
HK1122497B (en) Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other cns disorders
HK1123789B (en) Azabicyclic derivatives, preparation method thereof and pharmaceutical compositions containing same
FR2930941A1 (fr) Derives d'azetidines, leur preparation et leur application en therapeutique