MY128102A - Indolin-2-one-derivatives - Google Patents
Indolin-2-one-derivativesInfo
- Publication number
- MY128102A MY128102A MYPI94000344A MYPI9400344A MY128102A MY 128102 A MY128102 A MY 128102A MY PI94000344 A MYPI94000344 A MY PI94000344A MY PI9400344 A MYPI9400344 A MY PI9400344A MY 128102 A MY128102 A MY 128102A
- Authority
- MY
- Malaysia
- Prior art keywords
- lower alkyl
- heterocyclic
- aryl
- acyl
- treatment
- Prior art date
Links
- -1 CARBOXYL Chemical class 0.000 abstract 2
- 230000008485 antagonism Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010089335 Cholecystokinin A Receptor Proteins 0.000 abstract 1
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 1
- 102100034927 Cholecystokinin receptor type A Human genes 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000052874 Gastrin receptors Human genes 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 208000000689 peptic esophagitis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6729793 | 1993-02-17 | ||
| JP16726293 | 1993-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY128102A true MY128102A (en) | 2007-01-31 |
Family
ID=26408486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI94000344A MY128102A (en) | 1993-02-17 | 1994-02-16 | Indolin-2-one-derivatives |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US5952511A (enExample) |
| EP (1) | EP0685463B1 (enExample) |
| JP (1) | JP3419539B2 (enExample) |
| KR (1) | KR100226310B1 (enExample) |
| CN (1) | CN1046268C (enExample) |
| AT (1) | ATE217864T1 (enExample) |
| AU (1) | AU6044894A (enExample) |
| CA (1) | CA2156287C (enExample) |
| CZ (1) | CZ290504B6 (enExample) |
| DE (1) | DE69430664T2 (enExample) |
| ES (1) | ES2176236T3 (enExample) |
| FI (1) | FI112652B (enExample) |
| HU (1) | HUT74105A (enExample) |
| MY (1) | MY128102A (enExample) |
| NO (1) | NO305201B1 (enExample) |
| PL (1) | PL176710B1 (enExample) |
| RU (1) | RU2128170C1 (enExample) |
| TW (1) | TW281669B (enExample) |
| WO (1) | WO1994019322A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
| US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DK0731091T3 (da) * | 1993-11-26 | 2002-04-15 | Tanabe Seiyaku Co | 2-oxoindolin-derivater som cholecystokininreceptor-antagonister |
| MX9603909A (es) * | 1994-03-07 | 1997-03-29 | Vertex Pharma | Derivados de sulfonamida como inhibidores de proteasa aspartilo. |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| AU2233097A (en) * | 1996-03-11 | 1997-10-01 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of optically active indole compounds |
| WO1998002419A1 (en) * | 1996-07-12 | 1998-01-22 | Chugai Seiyaku Kabushiki Kaisha | Cancer cell proliferation inhibitors |
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| BR9912169A (pt) | 1998-06-19 | 2001-04-10 | Vertex Pharma | Inibidores de sulfonamida de protease de aspartil |
| ATE285769T1 (de) * | 1998-12-04 | 2005-01-15 | Neurosearch As | Verwendung von isatinderivaten als ionenkanalaktivierende mittel |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| EP1156037B1 (en) | 1999-01-29 | 2004-12-01 | Chugai Seiyaku Kabushiki Kaisha | Chondrongenesis promotors and indolin-2-one derivatives |
| DE60041763D1 (de) * | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| KR20100035666A (ko) | 1999-11-23 | 2010-04-05 | 메틸진 인크. | 히스톤 디아세틸라제의 억제제 |
| AU2001236058A1 (en) * | 2000-03-10 | 2001-09-17 | Chugai Seiyaku Kabushiki Kaisha | Preparations for chondrogenesis |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| AU2001268607A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Company | Piperidine amides as modulators of chemokine receptor activity |
| AU2001271357A1 (en) * | 2000-06-21 | 2002-01-02 | Dupont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| CA2508290C (en) * | 2002-12-20 | 2017-02-28 | Ciba Specialty Chemicals Holding Inc. | Synthesis of amines and intermediates for the synthesis thereof |
| CN1324009C (zh) * | 2003-01-30 | 2007-07-04 | 普文英 | 化合物1－n－甲氧基－2－氧－吲哚－3－乙酰胺及其药物用途 |
| KR101249865B1 (ko) * | 2004-10-27 | 2013-04-02 | 깃세이 야쿠힌 고교 가부시키가이샤 | 인돌린 화합물 및 그 제조방법 |
| US20080030974A1 (en) * | 2006-08-02 | 2008-02-07 | Abu-Ageel Nayef M | LED-Based Illumination System |
| US20090050905A1 (en) * | 2007-08-20 | 2009-02-26 | Abu-Ageel Nayef M | Highly Efficient Light-Emitting Diode |
| US20100202129A1 (en) * | 2009-01-21 | 2010-08-12 | Abu-Ageel Nayef M | Illumination system utilizing wavelength conversion materials and light recycling |
| US8987310B2 (en) | 2009-10-30 | 2015-03-24 | Merck Sharp & Dohme Corp. | Heterocycle amide T-type calcium channel antagonists |
| CN102516153B (zh) * | 2011-12-14 | 2014-03-12 | 南京工业大学 | 5-氟吲哚-2-酮-3-脲类化合物及其制备方法和应用 |
| RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
| KR102161674B1 (ko) * | 2014-02-18 | 2020-10-05 | 주식회사 대웅제약 | 이사틴 유도체 및 이의 제조방법 |
| CN113456631B (zh) * | 2021-08-06 | 2022-06-21 | 徐州医科大学 | 一种靶向acsl1的小分子药物及其在治疗子宫内膜癌中的应用 |
| CN117777002A (zh) * | 2023-12-04 | 2024-03-29 | 华南理工大学 | 一种3,3-二取代氧化吲哚衍生物的不对称合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| JPS62228072A (ja) | 1985-12-20 | 1987-10-06 | Kissei Pharmaceut Co Ltd | ３−アミノインドリン−２−オン誘導体 |
| JPS62234080A (ja) | 1985-12-20 | 1987-10-14 | Kissei Pharmaceut Co Ltd | インドリン−２−オン誘導体 |
| US4760083A (en) | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| JPS62270576A (ja) | 1986-05-19 | 1987-11-24 | Kissei Pharmaceut Co Ltd | イサチン誘導体 |
| JPS62156771A (ja) * | 1986-12-19 | 1987-07-11 | Tokyo Shokai:Kk | 処方箋処理装置 |
| JPS63156771A (ja) | 1986-12-19 | 1988-06-29 | Kissei Pharmaceut Co Ltd | ３−アミノインドリン−２−オン誘導体 |
| US4876259A (en) * | 1987-01-05 | 1989-10-24 | E. I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
| JPH03503650A (ja) * | 1988-04-05 | 1991-08-15 | アボツト・ラボラトリーズ | Ｃｃｋアンタゴニストとしてのトリプトファン誘導体 |
| CA2088980C (en) * | 1990-08-31 | 2002-04-16 | David C. Horwell | Pro-drugs for cck antagonists |
| WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
| CA2055094A1 (en) * | 1990-11-13 | 1992-05-14 | Mark G. Bock | Cholecystokinin antagonist |
| JPH05104510A (ja) * | 1991-10-18 | 1993-04-27 | Inax Corp | 基板へのモルタル塗布方法 |
-
1994
- 1994-02-16 JP JP05654194A patent/JP3419539B2/ja not_active Expired - Fee Related
- 1994-02-16 TW TW083101206A patent/TW281669B/zh active
- 1994-02-16 MY MYPI94000344A patent/MY128102A/en unknown
- 1994-02-17 AU AU60448/94A patent/AU6044894A/en not_active Abandoned
- 1994-02-17 WO PCT/JP1994/000235 patent/WO1994019322A1/ja not_active Ceased
- 1994-02-17 CZ CZ19952096A patent/CZ290504B6/cs not_active IP Right Cessation
- 1994-02-17 KR KR1019950703395A patent/KR100226310B1/ko not_active Expired - Fee Related
- 1994-02-17 DE DE69430664T patent/DE69430664T2/de not_active Expired - Fee Related
- 1994-02-17 PL PL94310168A patent/PL176710B1/pl not_active IP Right Cessation
- 1994-02-17 RU RU95120168A patent/RU2128170C1/ru not_active IP Right Cessation
- 1994-02-17 EP EP94907058A patent/EP0685463B1/en not_active Expired - Lifetime
- 1994-02-17 HU HU9502415A patent/HUT74105A/hu unknown
- 1994-02-17 AT AT94907058T patent/ATE217864T1/de not_active IP Right Cessation
- 1994-02-17 CA CA002156287A patent/CA2156287C/en not_active Expired - Fee Related
- 1994-02-17 ES ES94907058T patent/ES2176236T3/es not_active Expired - Lifetime
- 1994-02-17 CN CN94191205A patent/CN1046268C/zh not_active Expired - Fee Related
-
1995
- 1995-08-16 FI FI953866A patent/FI112652B/fi active
- 1995-08-17 NO NO953235A patent/NO305201B1/no unknown
-
1997
- 1997-11-03 US US08/963,547 patent/US5952511A/en not_active Expired - Fee Related
-
1998
- 1998-10-30 US US09/182,638 patent/US6031111A/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,463 patent/US6114536A/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,490 patent/US6207836B1/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,491 patent/US6127544A/en not_active Expired - Fee Related
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