HUT72926A - High molecular weight desulphatohirudin - Google Patents
High molecular weight desulphatohirudin Download PDFInfo
- Publication number
- HUT72926A HUT72926A HU9500689A HU9500689A HUT72926A HU T72926 A HUT72926 A HU T72926A HU 9500689 A HU9500689 A HU 9500689A HU 9500689 A HU9500689 A HU 9500689A HU T72926 A HUT72926 A HU T72926A
- Authority
- HU
- Hungary
- Prior art keywords
- hirudin
- desulfato
- conjugate
- mutein
- cys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93810552 | 1993-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9500689D0 HU9500689D0 (en) | 1995-06-28 |
| HUT72926A true HUT72926A (en) | 1996-06-28 |
Family
ID=8215008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9500689A HUT72926A (en) | 1993-08-04 | 1994-07-23 | High molecular weight desulphatohirudin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5661001A (de) |
| EP (1) | EP0663009A1 (de) |
| JP (1) | JPH08502661A (de) |
| KR (1) | KR950703645A (de) |
| CN (1) | CN1113389A (de) |
| AU (1) | AU685835B2 (de) |
| CA (1) | CA2144523A1 (de) |
| FI (1) | FI951541A0 (de) |
| HU (1) | HUT72926A (de) |
| IL (1) | IL110540A0 (de) |
| NO (1) | NO951277D0 (de) |
| NZ (1) | NZ271088A (de) |
| SG (1) | SG49862A1 (de) |
| WO (1) | WO1995004823A1 (de) |
| ZA (1) | ZA945775B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03007563A (es) * | 2001-02-23 | 2003-12-11 | Immunex Corp | Recuperacion incrementada de proteinas activas. |
| CN1328380C (zh) * | 2001-09-24 | 2007-07-25 | 天津天士力制药股份有限公司 | 高效表达水蛭素及其生产方法 |
| EP1906990B1 (de) | 2005-07-05 | 2013-12-11 | Baker Medical Research Institute | Antikoagulationsmittel |
| CN101993489B (zh) * | 2009-08-20 | 2013-10-23 | 重庆富进生物医药有限公司 | 可逆转水蛭素 |
| US7803762B1 (en) | 2009-08-20 | 2010-09-28 | The Medicines Company | Ready-to-use bivalirudin compositions |
| US7985733B1 (en) | 2010-01-06 | 2011-07-26 | The Medicines Company | Buffer-based method for preparing bivalirudin drug product |
| CN117534731A (zh) * | 2021-09-24 | 2024-02-09 | 江西康之康中药科技有限公司 | 一种抗凝血肽及其在抗凝血产品上的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| DE3479520D1 (en) * | 1983-11-21 | 1989-09-28 | Ciba Geigy Ag | Synthesis of tissue plasminogen activator(tpa) by yeast |
| US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
| GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
| IL86090A (en) * | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
| EP0368857B1 (de) * | 1987-05-11 | 1997-08-06 | Chiron Corporation | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen |
| CA1340646C (en) * | 1987-05-21 | 1999-07-13 | John L. Krstenansky | Cyclic anticoagulant peptides |
| US5236898A (en) * | 1987-05-21 | 1993-08-17 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
| GB8809860D0 (en) * | 1988-04-26 | 1988-06-02 | Ciba Geigy Ag | Process for production of polypeptides |
| AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
| ES2052062T3 (es) * | 1988-06-11 | 1994-07-01 | Ciba Geigy Ag | Nuevos polipeptidos con actividad anticoagulante. |
| US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
| WO1991008229A1 (de) * | 1989-12-01 | 1991-06-13 | Basf Aktiengesellschaft | Hirudinpolyalkylenglykolkonjugate |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| IT1248565B (it) * | 1991-06-27 | 1995-01-19 | Erba Carlo Spa | Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina. |
-
1994
- 1994-07-23 AU AU74605/94A patent/AU685835B2/en not_active Ceased
- 1994-07-23 SG SG9607691A patent/SG49862A1/en unknown
- 1994-07-23 WO PCT/EP1994/002438 patent/WO1995004823A1/en not_active Application Discontinuation
- 1994-07-23 JP JP7506182A patent/JPH08502661A/ja active Pending
- 1994-07-23 HU HU9500689A patent/HUT72926A/hu unknown
- 1994-07-23 CA CA002144523A patent/CA2144523A1/en not_active Abandoned
- 1994-07-23 EP EP94924281A patent/EP0663009A1/de not_active Withdrawn
- 1994-07-23 CN CN94190578A patent/CN1113389A/zh active Pending
- 1994-07-23 NZ NZ271088A patent/NZ271088A/en unknown
- 1994-07-23 KR KR1019950701272A patent/KR950703645A/ko not_active Application Discontinuation
- 1994-07-23 US US08/406,948 patent/US5661001A/en not_active Expired - Fee Related
- 1994-08-02 IL IL11054094A patent/IL110540A0/xx unknown
- 1994-08-03 ZA ZA945775A patent/ZA945775B/xx unknown
-
1995
- 1995-03-31 FI FI951541A patent/FI951541A0/fi unknown
- 1995-04-03 NO NO951277A patent/NO951277D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7460594A (en) | 1995-02-28 |
| NO951277L (no) | 1995-04-03 |
| NZ271088A (en) | 1996-10-28 |
| FI951541A (fi) | 1995-03-31 |
| ZA945775B (en) | 1995-02-06 |
| CA2144523A1 (en) | 1995-02-16 |
| FI951541A0 (fi) | 1995-03-31 |
| SG49862A1 (en) | 2002-03-19 |
| NO951277D0 (no) | 1995-04-03 |
| KR950703645A (ko) | 1995-09-20 |
| WO1995004823A1 (en) | 1995-02-16 |
| JPH08502661A (ja) | 1996-03-26 |
| US5661001A (en) | 1997-08-26 |
| HU9500689D0 (en) | 1995-06-28 |
| IL110540A0 (en) | 1994-11-11 |
| CN1113389A (zh) | 1995-12-13 |
| AU685835B2 (en) | 1998-01-29 |
| EP0663009A1 (de) | 1995-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: NOVARTIS AG, CH Owner name: UPC GEN-PHARMA AG., CH |
|
| DFC4 | Cancellation of temporary protection due to refusal |