IL110540A0 - High molecular weight desulphatohirudin - Google Patents

High molecular weight desulphatohirudin

Info

Publication number
IL110540A0
IL110540A0 IL11054094A IL11054094A IL110540A0 IL 110540 A0 IL110540 A0 IL 110540A0 IL 11054094 A IL11054094 A IL 11054094A IL 11054094 A IL11054094 A IL 11054094A IL 110540 A0 IL110540 A0 IL 110540A0
Authority
IL
Israel
Prior art keywords
desulphatohirudin
molecular weight
high molecular
weight
weight desulphatohirudin
Prior art date
Application number
IL11054094A
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of IL110540A0 publication Critical patent/IL110540A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • A61K38/58Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL11054094A 1993-08-04 1994-08-02 High molecular weight desulphatohirudin IL110540A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04

Publications (1)

Publication Number Publication Date
IL110540A0 true IL110540A0 (en) 1994-11-11

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11054094A IL110540A0 (en) 1993-08-04 1994-08-02 High molecular weight desulphatohirudin

Country Status (15)

Country Link
US (1) US5661001A (de)
EP (1) EP0663009A1 (de)
JP (1) JPH08502661A (de)
KR (1) KR950703645A (de)
CN (1) CN1113389A (de)
AU (1) AU685835B2 (de)
CA (1) CA2144523A1 (de)
FI (1) FI951541A0 (de)
HU (1) HUT72926A (de)
IL (1) IL110540A0 (de)
NO (1) NO951277D0 (de)
NZ (1) NZ271088A (de)
SG (1) SG49862A1 (de)
WO (1) WO1995004823A1 (de)
ZA (1) ZA945775B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03007563A (es) * 2001-02-23 2003-12-11 Immunex Corp Recuperacion incrementada de proteinas activas.
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
EP1906990B1 (de) 2005-07-05 2013-12-11 Baker Medical Research Institute Antikoagulationsmittel
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
CN117534731A (zh) * 2021-09-24 2024-02-09 江西康之康中药科技有限公司 一种抗凝血肽及其在抗凝血产品上的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DE3479520D1 (en) * 1983-11-21 1989-09-28 Ciba Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0368857B1 (de) * 1987-05-11 1997-08-06 Chiron Corporation Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
IT1248565B (it) * 1991-06-27 1995-01-19 Erba Carlo Spa Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Also Published As

Publication number Publication date
AU7460594A (en) 1995-02-28
NO951277L (no) 1995-04-03
NZ271088A (en) 1996-10-28
FI951541A (fi) 1995-03-31
ZA945775B (en) 1995-02-06
CA2144523A1 (en) 1995-02-16
FI951541A0 (fi) 1995-03-31
SG49862A1 (en) 2002-03-19
NO951277D0 (no) 1995-04-03
KR950703645A (ko) 1995-09-20
WO1995004823A1 (en) 1995-02-16
JPH08502661A (ja) 1996-03-26
US5661001A (en) 1997-08-26
HUT72926A (en) 1996-06-28
HU9500689D0 (en) 1995-06-28
CN1113389A (zh) 1995-12-13
AU685835B2 (en) 1998-01-29
EP0663009A1 (de) 1995-07-19

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