NO951277L - Desulfatohirudin med höy molekylvekt - Google Patents

Desulfatohirudin med höy molekylvekt

Info

Publication number
NO951277L
NO951277L NO951277A NO951277A NO951277L NO 951277 L NO951277 L NO 951277L NO 951277 A NO951277 A NO 951277A NO 951277 A NO951277 A NO 951277A NO 951277 L NO951277 L NO 951277L
Authority
NO
Norway
Prior art keywords
desulfatohirudin
molecular weight
high molecular
desulfato
thrombin
Prior art date
Application number
NO951277A
Other languages
English (en)
Other versions
NO951277D0 (no
Inventor
Hugo Grossenbacher
Jui Yoa Chang
Walter Marki
Original Assignee
Ciba Geigy Ag
Upc Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Upc Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of NO951277L publication Critical patent/NO951277L/no
Publication of NO951277D0 publication Critical patent/NO951277D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Thrombininhibitorer og produksjon av modifiserte desulfatohlrudlner ved hjelp av genetisk omkonstruerlng samt en fremgangsmåte for denaturerlng og renaturerlng av et modifisert desulfatohlrudln til en biologisk aktiv thromblnlnhibitor og kombinasjonen av to eller flere desulfatohlrudlner for å danne thrmombin- inhlbltorer med høyere molekylvekt, er beskrevet.
NO951277A 1993-08-04 1995-04-03 Desulfatohirudin med höy molekylvekt NO951277D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04
PCT/EP1994/002438 WO1995004823A1 (en) 1993-08-04 1994-07-23 High molecular weight desulphatohirudin

Publications (2)

Publication Number Publication Date
NO951277L true NO951277L (no) 1995-04-03
NO951277D0 NO951277D0 (no) 1995-04-03

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951277A NO951277D0 (no) 1993-08-04 1995-04-03 Desulfatohirudin med höy molekylvekt

Country Status (15)

Country Link
US (1) US5661001A (no)
EP (1) EP0663009A1 (no)
JP (1) JPH08502661A (no)
KR (1) KR950703645A (no)
CN (1) CN1113389A (no)
AU (1) AU685835B2 (no)
CA (1) CA2144523A1 (no)
FI (1) FI951541A0 (no)
HU (1) HUT72926A (no)
IL (1) IL110540A0 (no)
NO (1) NO951277D0 (no)
NZ (1) NZ271088A (no)
SG (1) SG49862A1 (no)
WO (1) WO1995004823A1 (no)
ZA (1) ZA945775B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1547586A (zh) * 2001-02-23 2004-11-17 ���鹫˾ 提高的活性蛋白回收率
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
KR20080031383A (ko) 2005-07-05 2008-04-08 베이커 메디컬 리서치 인스티튜트 항응고제 및 그의 용도
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
CN117534731A (zh) * 2021-09-24 2024-02-09 江西康之康中药科技有限公司 一种抗凝血肽及其在抗凝血产品上的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR80966B (en) * 1983-11-21 1985-03-15 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
JP2955294B2 (ja) * 1987-05-11 1999-10-04 カイロン コーポレイション 微生物から精製され、酸化され、再生された組換えインターロイキン‐２を回収する方法
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
IT1248565B (it) * 1991-06-27 1995-01-19 Erba Carlo Spa Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Also Published As

Publication number Publication date
KR950703645A (ko) 1995-09-20
FI951541A (fi) 1995-03-31
FI951541A0 (fi) 1995-03-31
CA2144523A1 (en) 1995-02-16
AU685835B2 (en) 1998-01-29
US5661001A (en) 1997-08-26
HU9500689D0 (en) 1995-06-28
HUT72926A (en) 1996-06-28
NZ271088A (en) 1996-10-28
JPH08502661A (ja) 1996-03-26
CN1113389A (zh) 1995-12-13
IL110540A0 (en) 1994-11-11
ZA945775B (en) 1995-02-06
SG49862A1 (en) 2002-03-19
NO951277D0 (no) 1995-04-03
WO1995004823A1 (en) 1995-02-16
EP0663009A1 (en) 1995-07-19
AU7460594A (en) 1995-02-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application