SG49862A1 - High molecular weight desulphatohirudin - Google Patents

High molecular weight desulphatohirudin

Info

Publication number
SG49862A1
SG49862A1 SG9607691A SG1996007691A SG49862A1 SG 49862 A1 SG49862 A1 SG 49862A1 SG 9607691 A SG9607691 A SG 9607691A SG 1996007691 A SG1996007691 A SG 1996007691A SG 49862 A1 SG49862 A1 SG 49862A1
Authority
SG
Singapore
Prior art keywords
desulphatohirudin
molecular weight
high molecular
weight
weight desulphatohirudin
Prior art date
Application number
SG9607691A
Other languages
English (en)
Inventor
Jui Yoa Chang
Hugo Grossenbacher
Walter Marki
Original Assignee
Ucp Gen Pharma Ag
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucp Gen Pharma Ag, Novartis Ag filed Critical Ucp Gen Pharma Ag
Publication of SG49862A1 publication Critical patent/SG49862A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG9607691A 1993-08-04 1994-07-23 High molecular weight desulphatohirudin SG49862A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04

Publications (1)

Publication Number Publication Date
SG49862A1 true SG49862A1 (en) 2002-03-19

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9607691A SG49862A1 (en) 1993-08-04 1994-07-23 High molecular weight desulphatohirudin

Country Status (15)

Country Link
US (1) US5661001A (no)
EP (1) EP0663009A1 (no)
JP (1) JPH08502661A (no)
KR (1) KR950703645A (no)
CN (1) CN1113389A (no)
AU (1) AU685835B2 (no)
CA (1) CA2144523A1 (no)
FI (1) FI951541A0 (no)
HU (1) HUT72926A (no)
IL (1) IL110540A0 (no)
NO (1) NO951277D0 (no)
NZ (1) NZ271088A (no)
SG (1) SG49862A1 (no)
WO (1) WO1995004823A1 (no)
ZA (1) ZA945775B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20032208A3 (cs) * 2001-02-23 2004-01-14 Immunex Corporation Zvýšený výtěžek aktivních proteinů
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
KR20080031383A (ko) 2005-07-05 2008-04-08 베이커 메디컬 리서치 인스티튜트 항응고제 및 그의 용도
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291982A2 (en) * 1987-05-21 1988-11-23 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
WO1993000363A1 (en) * 1991-06-27 1993-01-07 Farmitalia Carlo Erba S.R.L. Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0143081B1 (en) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
ATE156491T1 (de) * 1987-05-11 1997-08-15 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291982A2 (en) * 1987-05-21 1988-11-23 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
WO1993000363A1 (en) * 1991-06-27 1993-01-07 Farmitalia Carlo Erba S.R.L. Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin

Also Published As

Publication number Publication date
KR950703645A (ko) 1995-09-20
WO1995004823A1 (en) 1995-02-16
CA2144523A1 (en) 1995-02-16
AU7460594A (en) 1995-02-28
EP0663009A1 (en) 1995-07-19
FI951541A (fi) 1995-03-31
NO951277L (no) 1995-04-03
AU685835B2 (en) 1998-01-29
ZA945775B (en) 1995-02-06
HUT72926A (en) 1996-06-28
HU9500689D0 (en) 1995-06-28
FI951541A0 (fi) 1995-03-31
NO951277D0 (no) 1995-04-03
JPH08502661A (ja) 1996-03-26
US5661001A (en) 1997-08-26
IL110540A0 (en) 1994-11-11
CN1113389A (zh) 1995-12-13
NZ271088A (en) 1996-10-28

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