HUP9903515A2 - Új antiprogesztacionális szerként használható 21-helyzetben szubsztituált progeszteronszármazékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk - Google Patents

Új antiprogesztacionális szerként használható 21-helyzetben szubsztituált progeszteronszármazékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk

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Publication number
HUP9903515A2
HUP9903515A2 HU9903515A HUP9903515A HUP9903515A2 HU P9903515 A2 HUP9903515 A2 HU P9903515A2 HU 9903515 A HU9903515 A HU 9903515A HU P9903515 A HUP9903515 A HU P9903515A HU P9903515 A2 HUP9903515 A2 HU P9903515A2
Authority
HU
Hungary
Prior art keywords
alkyl
treat
acyl
hydroxy
compounds
Prior art date
Application number
HU9903515A
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English (en)
Inventor
Carmie K. Acosta
Richard P. Blye
James W. Cessac
Hyun K. Kim
Pemmaraju N. Rao
Original Assignee
The Government Of The United States Of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by The Government Of The United States Of America filed Critical The Government Of The United States Of America
Publication of HUP9903515A2 publication Critical patent/HUP9903515A2/hu
Publication of HUP9903515A3 publication Critical patent/HUP9903515A3/hu
Publication of HU230492B1 publication Critical patent/HU230492B1/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005Ketals
    • C07J21/006Ketals at position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016Oximes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát (I) általánős képletű vegyületek képezik, ahől R1 jelentése -OCH3, -SCH3, -N(CH3)2, -NHCH3, -CHO, -COCH3 és -CHOHCH3csőpőrt; R2 jelentése halőgénatőm, alkil-, acil-, hidrőxi-, alkőxi-,acilőxicsőpőrt, alkil-karbőnát-, cipiőnil-őxi-, S-alkil- vagy S-acil-csőpőrt, R3 jelentése alkilcsőpőrt, hidrőxi-, alkőxi- vagy acil-őxi-csőpőrt; R4 jelentése hidrőgénatőm vagy alkilcsőpőrt; és X jelentése =O vagy =N-OR5 általánős képletű csőpőrt, ahől R5jelentése hidrőgénatőm vagy alkilcsőpőrt. A vegyületek többek közöttendőgén prőgeszterőn antagőnizáló hatásúak, és így menstrűációkiváltására, endőmetriózis kezelésére, diszmenőrrea kezelésére,endőkrin hőrmőnfüggő tűmőrők kezelésére, méhfibróma kezelésére,méhendőmetriűm-bűrjánzás gátlására, szülés kiváltására ésfőgamzásgátlásra használhatók. A találmány a vegyületeket tartalmazógyógyszerkészítményekre is vőnatkőzik. ŕ
HU9903515A 1996-05-01 1997-04-30 Új progesztációt gátló szerként használható 21-helyzetben szubsztituált progeszteron-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk HU230492B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1662896P 1996-05-01 1996-05-01
US60/016,628 1996-05-01
PCT/US1997/007373 WO1997041145A1 (en) 1996-05-01 1997-04-30 21-substituted progesterone derivatives as new antiprogestational agents

Publications (3)

Publication Number Publication Date
HUP9903515A2 true HUP9903515A2 (hu) 2000-03-28
HUP9903515A3 HUP9903515A3 (en) 2000-04-28
HU230492B1 HU230492B1 (hu) 2016-08-29

Family

ID=21778122

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903515A HU230492B1 (hu) 1996-05-01 1997-04-30 Új progesztációt gátló szerként használható 21-helyzetben szubsztituált progeszteron-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk

Country Status (13)

Country Link
US (4) US6861415B2 (hu)
EP (1) EP0900234B1 (hu)
JP (1) JP4260886B2 (hu)
AT (1) ATE194358T1 (hu)
AU (1) AU710139B2 (hu)
CA (2) CA2668824A1 (hu)
DE (1) DE69702450T2 (hu)
DK (1) DK0900234T3 (hu)
ES (1) ES2152671T3 (hu)
GR (1) GR3034562T3 (hu)
HU (1) HU230492B1 (hu)
PT (1) PT900234E (hu)
WO (1) WO1997041145A1 (hu)

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US7087591B2 (en) 2006-08-08
GR3034562T3 (en) 2001-01-31
US20050143364A1 (en) 2005-06-30
CA2253673C (en) 2009-09-08
ES2152671T3 (es) 2001-02-01
US7759330B2 (en) 2010-07-20
CA2253673A1 (en) 1997-11-06
JP2000509396A (ja) 2000-07-25
CA2668824A1 (en) 1997-11-06
US20060276443A1 (en) 2006-12-07
WO1997041145A1 (en) 1997-11-06
EP0900234A1 (en) 1999-03-10
JP4260886B2 (ja) 2009-04-30
DE69702450T2 (de) 2001-03-08
AU710139B2 (en) 1999-09-16
US20100113408A1 (en) 2010-05-06
DK0900234T3 (da) 2000-11-06
US6861415B2 (en) 2005-03-01
ATE194358T1 (de) 2000-07-15
AU2930497A (en) 1997-11-19
DE69702450D1 (de) 2000-08-10
HUP9903515A3 (en) 2000-04-28
EP0900234B1 (en) 2000-07-05
US8003629B2 (en) 2011-08-23
PT900234E (pt) 2000-12-29
US20020025951A1 (en) 2002-02-28

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