HUP0900171A2 - 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására - Google Patents

17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására

Info

Publication number
HUP0900171A2
HUP0900171A2 HU0900171A HUP0900171A HUP0900171A2 HU P0900171 A2 HUP0900171 A2 HU P0900171A2 HU 0900171 A HU0900171 A HU 0900171A HU P0900171 A HUP0900171 A HU P0900171A HU P0900171 A2 HUP0900171 A2 HU P0900171A2
Authority
HU
Hungary
Prior art keywords
norpregna
metoxy
dien
acetoxy
dione
Prior art date
Application number
HU0900171A
Other languages
English (en)
Inventor
Csaba Santa
Adam Dr Demeter
Balazs Dr Havasi
Sandor Maho
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU0900171A priority Critical patent/HUP0900171A2/hu
Publication of HU0900171D0 publication Critical patent/HU0900171D0/hu
Priority to EP10714358.8A priority patent/EP2408799B1/en
Priority to PCT/HU2010/000030 priority patent/WO2010106383A1/en
Priority to US13/256,914 priority patent/US8513228B2/en
Priority to HUE10714358A priority patent/HUE025398T2/hu
Priority to PL10714358T priority patent/PL2408799T3/pl
Priority to ES10714358.8T priority patent/ES2547062T3/es
Publication of HUP0900171A2 publication Critical patent/HUP0900171A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0900171A 2009-02-20 2009-03-20 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására HUP0900171A2 (hu)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HU0900171A HUP0900171A2 (hu) 2009-03-20 2009-03-20 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására
EP10714358.8A EP2408799B1 (en) 2009-03-20 2010-03-22 Novel crystalline form of antiprogestin cdb-4124
PCT/HU2010/000030 WO2010106383A1 (en) 2009-03-20 2010-03-22 Novel crystalline form of antiprogestin cdb-4124
US13/256,914 US8513228B2 (en) 2009-02-20 2010-03-22 Crystalline form of antiprogestin CDB-4124
HUE10714358A HUE025398T2 (hu) 2009-03-20 2010-03-22 CDB-4124 új kristályos módosulata
PL10714358T PL2408799T3 (pl) 2009-03-20 2010-03-22 Nowa krystaliczna postać anty-progesteronu CDB-4124
ES10714358.8T ES2547062T3 (es) 2009-03-20 2010-03-22 Nueva forma cristalina de la antiprogestina CDB-4124

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0900171A HUP0900171A2 (hu) 2009-03-20 2009-03-20 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására

Publications (2)

Publication Number Publication Date
HU0900171D0 HU0900171D0 (en) 2009-05-28
HUP0900171A2 true HUP0900171A2 (hu) 2010-12-28

Family

ID=89988855

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0900171A HUP0900171A2 (hu) 2009-02-20 2009-03-20 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására
HUE10714358A HUE025398T2 (hu) 2009-03-20 2010-03-22 CDB-4124 új kristályos módosulata

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE10714358A HUE025398T2 (hu) 2009-03-20 2010-03-22 CDB-4124 új kristályos módosulata

Country Status (6)

Country Link
US (1) US8513228B2 (hu)
EP (1) EP2408799B1 (hu)
ES (1) ES2547062T3 (hu)
HU (2) HUP0900171A2 (hu)
PL (1) PL2408799T3 (hu)
WO (1) WO2010106383A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900487A2 (hu) * 2009-08-05 2011-03-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4260886B2 (ja) * 1996-05-01 2009-04-30 アメリカ合衆国 新規の抗プロゲステロンとしての２１―置換プロゲステロン誘導体
ATE299886T1 (de) 1999-12-29 2005-08-15 Us Gov Health & Human Serv Verfahren zur herstellung von 17alpha-acetoxy-
DE60134126D1 (de) 2000-03-17 2008-07-03 Us Gov Health & Human Serv 17-alpha-substituierte-11-beta-substituierte-4-aryl und 21-substituierte 19-norpregnadienedione mit antigestagener aktivität
US8044223B2 (en) * 2003-04-04 2011-10-25 Bridge Organics Co. Crystalline 19-norsteroids
EP2125858A2 (en) * 2007-01-17 2009-12-02 Repros Therapeutics Inc. Pharmaceutically acceptable salts of 11-(4-aminophenyl)-19-norpregna-4,9(10)-diene-3,20-dione derivatives
HU228636B1 (en) * 2007-06-27 2013-04-29 Richter Gedeon Nyrt Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
TW201002736A (en) * 2008-04-28 2010-01-16 Repros Therapeutics Inc Compositions and methods for treating progesterone-dependent conditions
HUP0900487A2 (hu) * 2009-08-05 2011-03-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására

Also Published As

Publication number Publication date
US8513228B2 (en) 2013-08-20
EP2408799B1 (en) 2015-07-01
WO2010106383A8 (en) 2011-07-14
HU0900171D0 (en) 2009-05-28
US20120077791A1 (en) 2012-03-29
HUE025398T2 (hu) 2016-02-29
EP2408799A1 (en) 2012-01-25
WO2010106383A1 (en) 2010-09-23
ES2547062T3 (es) 2015-10-01
PL2408799T3 (pl) 2015-12-31

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished