ATE299886T1 - Verfahren zur herstellung von 17alpha-acetoxy- - Google Patents
Verfahren zur herstellung von 17alpha-acetoxy-Info
- Publication number
- ATE299886T1 ATE299886T1 AT00989551T AT00989551T ATE299886T1 AT E299886 T1 ATE299886 T1 AT E299886T1 AT 00989551 T AT00989551 T AT 00989551T AT 00989551 T AT00989551 T AT 00989551T AT E299886 T1 ATE299886 T1 AT E299886T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl
- member selected
- treat
- formula
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005910 alkyl carbonate group Chemical group 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 230000002357 endometrial effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 210000004914 menses Anatomy 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17347099P | 1999-12-29 | 1999-12-29 | |
| PCT/US2000/035479 WO2001047945A1 (en) | 1999-12-29 | 2000-12-29 | Process for preparing 17alpha-acetoxy-11beta-[4-n,n-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299886T1 true ATE299886T1 (de) | 2005-08-15 |
Family
ID=22632177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00989551T ATE299886T1 (de) | 1999-12-29 | 2000-12-29 | Verfahren zur herstellung von 17alpha-acetoxy- |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6768014B2 (de) |
| EP (1) | EP1242444B1 (de) |
| AT (1) | ATE299886T1 (de) |
| AU (1) | AU775831B2 (de) |
| CA (1) | CA2394731C (de) |
| DE (1) | DE60021422T2 (de) |
| WO (1) | WO2001047945A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
| ES2212912B1 (es) * | 2003-01-22 | 2005-10-01 | Crystal Pharma, S.A. | Procedimiento para la obtencion de 17alfa-acetoxi-11beta-(4-n,n-dimetilaminofenil)-19-norpregna-4,9-dien-3,20-diona. |
| US8044223B2 (en) * | 2003-04-04 | 2011-10-25 | Bridge Organics Co. | Crystalline 19-norsteroids |
| HU227112B1 (hu) * | 2006-06-14 | 2010-07-28 | Richter Gedeon Nyrt | Ipari eljárás 17-alfa-acetoxi-11-béta-[4-(N,N-dimetil-amino)-fenil]-19-norpregna-4,9-dién-3,20-dion elõállítására és új intermedierek az eljáráshoz |
| ES2814343T3 (es) | 2006-10-24 | 2021-03-26 | Allergan Pharmaceuticals Int Ltd | Composiciones y métodos para suprimir las proliferaciones endometriales |
| HU228636B1 (en) * | 2007-06-27 | 2013-04-29 | Richter Gedeon Nyrt | Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process |
| HUP0900171A2 (hu) | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására |
| US8673968B2 (en) * | 2009-04-06 | 2014-03-18 | Evestra, Inc. | Progesterone antagonists |
| HUP0900487A2 (hu) | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására |
| US9096641B2 (en) | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
| HU230381B1 (hu) | 2014-02-17 | 2016-03-29 | Richter Gedeon Nyrt | Ipari eljárás szteroid intermedier előállítására |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE653974A (de) | 1963-10-04 | |||
| US3956316A (en) | 1964-09-29 | 1976-05-11 | Hoffmann-La Roche Inc. | 11-Substituted-desA-pregnanes and derivatives thereof |
| US3496199A (en) | 1968-06-17 | 1970-02-17 | Hoffmann La Roche | Process for the preparation of 9beta,10alpha-steroids |
| US4511511A (en) | 1982-12-15 | 1985-04-16 | Crozer-Chester Medical Center | Prednisolone derivatives |
| ATE165074T1 (de) | 1993-12-16 | 1998-05-15 | Sigma Tau Ind Farmaceuti | Verfahren zur oxidation von primären und sekundären alkoholen zu aldehyden und ketonen und zur oxidation von 1,2-diolen zu alpha-ketolen und alpha-diketonen |
| PT900234E (pt) | 1996-05-01 | 2000-12-29 | Us Gov Health & Human Serv | Derivados de progesterona substituidos em 21 que podem ser utilizados como novos agentes antiprogestativos |
-
2000
- 2000-12-29 CA CA002394731A patent/CA2394731C/en not_active Expired - Fee Related
- 2000-12-29 US US10/169,139 patent/US6768014B2/en not_active Expired - Lifetime
- 2000-12-29 EP EP00989551A patent/EP1242444B1/de not_active Expired - Lifetime
- 2000-12-29 AU AU26048/01A patent/AU775831B2/en not_active Ceased
- 2000-12-29 AT AT00989551T patent/ATE299886T1/de active
- 2000-12-29 DE DE60021422T patent/DE60021422T2/de not_active Expired - Lifetime
- 2000-12-29 WO PCT/US2000/035479 patent/WO2001047945A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242444A1 (de) | 2002-09-25 |
| CA2394731A1 (en) | 2001-07-05 |
| DE60021422D1 (de) | 2005-08-25 |
| US6768014B2 (en) | 2004-07-27 |
| DE60021422T2 (de) | 2006-05-24 |
| CA2394731C (en) | 2008-08-26 |
| WO2001047945A1 (en) | 2001-07-05 |
| AU2604801A (en) | 2001-07-09 |
| EP1242444B1 (de) | 2005-07-20 |
| US20030060646A1 (en) | 2003-03-27 |
| AU775831B2 (en) | 2004-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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